Results 171 to 180 of about 1,260,166 (238)

Guianensin, a Blackfly Salivary Protein, Inhibits the Lectin Pathway of Complement. [PDF]

J Med Chem
Valenzuela Leon PC, Ring ME, Nishiduka E, Bonilla B, Cruz P, Martinez EP, Percopo C, Calvo E.   +7 more
europepmc   +1 more source

Brain death-induced lung injury is complement dependent, with a primary role for the classical/lectin pathway. [PDF]

Am J Transplant, 2021
van Zanden JE, Jager NM, Seelen MA, Daha MR, Veldhuis ZJ, Leuvenink HGD, Erasmus ME.   +6 more
europepmc   +1 more source

Deficiency of high‐molecular‐weight von Willebrand factor mitigates thrombo‐complement injury in an LPS‐induced TMA‐like mouse model

VIEW, EarlyView.
Reduction of high‐molecular‐weight von Willebrand factor disrupts the platelet–complement amplification loop, attenuating microvascular thrombosis, complement deposition, endothelial injury, and organ damage in complement‐mediated thrombotic microangiopathy.
Yang Li, Chihao Zhang, Xiaoqian Xu, Sicong Wang, Xiaofan Hu, Junjie Yao, Xi Wu, Difeng Zhu, Qian Liang, Yeling Lu, Yu Liu, Guanqun Xu, Jiakuan Zhou, Qiulan Ding, Wenman Wu, Ya Li, Jing Dai, Xuefeng Wang   +17 more
wiley   +1 more source

Activation of the Complement/Lectin Pathway, Angiopoietin/Tie-2/VEGF-System, Cytokines and Chemokines in Different Angioedema Subtypes. [PDF]

Eur J Immunol
Duda KM, Gehring M, Wedi B.
europepmc   +1 more source

Exopolysaccharides From Lactobacillus delbrueckii subsp. bulgaricus OLL1073R‐1 Enhance Macrophage Bactericidal Activity Through IL‐12‐Dependent Macrophage–NK Cell Crosstalk

Microbiology and Immunology, EarlyView.
ABSTRACT Exopolysaccharides (EPS) produced by Lactobacillus delbrueckii subsp. bulgaricus OLL1073R‐1 have been reported to exert immunomodulatory effects, primarily in antiviral responses; however, their role in antibacterial host defense remains unclear. Here, we investigated whether EPS enhance macrophage‐mediated killing of Streptococcus pyogenes, a
Chikara Kohda, Hiroki Ishikawa, Yoshihiro Kuno, Yasunari Matsuzaka, Hiroki Kono, Toshihiro Sashihara, Hirotaka Kuwata, Masayuki Iyoda   +7 more
wiley   +1 more source

Complement activation promoted by the lectin pathway mediates C3aR-dependent sarcoma progression and immunosuppression. [PDF]

Nat Cancer, 2021
Magrini E, Di Marco S, Mapelli SN, Perucchini C, Pasqualini F, Donato A, Guevara Lopez ML, Carriero R, Ponzetta A, Colombo P, Cananzi F, Supino D, Reis ES, Peano C, Inforzato A, Jaillon S, Doni A, Lambris JD, Mantovani A, Garlanda C.   +19 more
europepmc   +1 more source

Targeting the complement lectin pathway with a highly specific MASP-2 inhibitor protects against renal ischemia-reperfusion injury. [PDF]

Proc Natl Acad Sci U S A
Bongoni AK, Kiss B, McRae JL, Salvaris EJ, Fisicaro N, Muntz F, Németh BZ, Nagy ZA, Kocsis A, Gál P, Cowan PJ, Pál G.   +11 more
europepmc   +1 more source

Lupus Panniculitis Immunoprofiling Reveals a Cytotoxic, Type 1‐Skewed T‐Cell Response With Signs of Metabolic Alteration

Allergy, EarlyView.
Imaging mass cytometry shows lupus panniculitis lesions are dominated by cytotoxic and skin‐homing T cells with abundant macrophages and B‐cell aggregates. Spatial neighborhood analysis reveals organized leukocyte architecture, including B‐cell proximity to naïve T cells and M1 macrophages to cytotoxic T cells.
Milad Ameri, Reihane Ziadlou, Stephan Traidl, Milena Sokolowska, Emmanuel Contassot, Nick Li, Maija Kiuru, Isabel Kolm, Werner Kempf, Emanual Maverakis, Cezmi Akdis, Marie‐Charlotte Brüggen   +11 more
wiley   +1 more source

<i>Echinococcus multilocularis</i> Calreticulin Inhibits Lectin Pathway of Complement Activation by Directly Binding to Mannose-Binding Lectin. [PDF]

Pathogens
Shao Y, Xia M, Song Y, Yan Y, Dong X, Zong H, Zhan B, Wang Y, Zhao L.   +8 more
europepmc   +1 more source

Diet–Microbiome–Immune Interactions at the Gut Mucosa in Food Allergy: Mechanisms, Gaps, and Therapeutic Implications

Allergy, EarlyView.
ABSTRACT Mucosal surfaces are sites of highly dynamic interactions among epithelial and immune cells, environmental exposures, particularly dietary inputs, and the diverse microbial communities and their metabolites. These elements continually influence each other to maintain homeostasis and ensure appropriate immune discrimination between pathogens ...
Clara Delaroque, Liam O'Mahony, Inge Kortekaas Krohn, Charlotte G. Mortz, Markus Ollert, Mahesh S. Desai   +5 more
wiley   +1 more source