Results 211 to 220 of about 104,017 (255)

The Lectin Pathway of Complement and Biocompatibility

2015
In modern health technologies the use of biomaterials in the form of stents, haemodialysis tubes, artificial implants, bypass circuits etc. is rapidly expanding. The exposure of synthetic, foreign surfaces to the blood and tissue of the host, calls for strict biocompatibility in respect to contact activation, the coagulation system and the complement ...
Hein, Estrid, Garred, Peter
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The Lectin Pathway of the Complement System

Microbiology and Immunology, 1996
One of the activities of animal lectins is the elimination of pathogens from a host. Serum mannose (or mannan)-binding protein (MBP) (25), in this capacity, recognizes mannose or N-acetylglucosamine on the surfaces of microorganisms. MBP is a member of the 'collectin' family (6), a group of C-type Ca2+-denendent animal lectins (3) which includes two ...
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Asparaginase inhibits the lectin pathway of complement activation

Molecular Immunology, 2018
Oncological treatment has been associated with an increased risk of infection, most often related to therapy-induced pancytopenia. However, limited research has been conducted on the effect of oncological therapy on the complement system, being part of the non-cellular innate immune system. This became the rationale for an observational clinical study (
Keizer, M. P., Aarts, C., Kamp, A. M., Caron, H. N., van de Wetering, M. D., Wouters, D., Kuijpers, T. W.   +6 more
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Activation of the lectin complement pathway by ficolins

International Immunopharmacology, 2001
Mannose-binding lectin (MBL), a serum lectin specific for mannose or N-acetylglucosamine (GlcNAc), which contains both a collagen-like domain and a carbohydrate-recognition domain (CRD), plays a role in innate immunity by acting as an opsonin and activating complement in association with MBL-associated serine protease (MASP) via the lectin pathway ...
M, Matsushita, Y, Endo, N, Hamasaki, T, Fujita   +3 more
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Lectin pathway influences the severity of leprosy

2022
This study aimed to evaluate the influence of the lectin pathway proteins Mannose-binding lectin (MBL) and ficolins (FCNs) MBL and FCN3) on leprosy’s susceptibility and severity. We studied patients with a confirmed diagnosis of leprosy (n=90) and their healthy household contacts (n=79).
FRANCISCA JACINTA FEITOZA DE OLIVEIRA, Anete Grumach, Rosemeire Constantino-Silva   +2 more
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Lectins and protein traffic early in the secretory pathway

Biochemical Society Symposia, 2002
Lectins of the early secretory pathway are involved in selective transport of newly synthesized glycoproteins from the endoplasmic reticulum (ER) to the ER–Golgi intermediate compartment (ERGIC). The most prominent cycling lectin is the mannose-binding type I membrane protein ERGIC-53 (ERGIC protein of 53 kDa), a marker for the ERGIC, which functions ...
Hauri, Hans-Peter, Nufer, Oliver, Breuza, Lionel, Tekaya, Houchaima Ben, Liang, Lu   +4 more
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Derivatives of the lectin complement pathway in Lophotrochozoa

Developmental & Comparative Immunology, 2019
A plethora of non-overlapping immune molecular mechanisms in metazoans is the most puzzling issue in comparative immunobiology. No valid evolutionary retrospective on these mechanisms has been developed. In this study, we aimed to reveal the origin and evolution of the immune complement-like system in Lophotrochozoa.
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Activation of the lectin pathway in murine lupus nephritis

Molecular Immunology, 2005
In systemic lupus erythematosus (SLE), hypocomplementaemia and complement deposition have been described both in man and in experimental models. A major involvement of the classical pathway of complement activation has been demonstrated in this disease, however relatively little is known about the involvement of the lectin pathway.
Leendert A, Trouw, Marc A, Seelen, Jacques M G J, Duijs, Sven, Wagner, Michael, Loos, Ingeborg M, Bajema, Cees, van Kooten, Anja, Roos, Mohamed R, Daha   +8 more
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The lectin pathway in renal disease

Nephrology, Dialysis, Transplantation, 2018
The complement system is composed of a network of at least 40 proteins, which significantly contributes to health and disease. The lectin pathway (LP) is one of three pathways that can activate the complement system. Next to protection of the host against pathogens, the LP has been shown to play a crucial role in multiple renal diseases as well as ...
da Costa, Mariana Gaya, Poppelaars, Felix, Berger, Stefan P., Daha, Mohamed R., Seelen, Marc A.   +4 more
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The lectin pathway

Research in Immunology, 1996
M, Matsushita, T, Fujita
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