Results 271 to 280 of about 2,474,660 (311)

complement classical and lectin pathways

2010
The classical and lectin pathways of complement are major recognition systems of innate immunity that are found in mammals and other animal species. By means of several multimolecular proteases – C1, the mannan-binding lectin (MBL)–MBL-associated serine protease 2 (MBL–MASP-2) and the ficolin–MASP-2 complexes – each comprising a recognition protein and
Thielens, Nicole, Gaboriaud, Christine, Thiel, Steffen   +2 more
openaire   +3 more sources

Lysis via the lectin pathway of complement activation: minireview and lectin pathway enhancement of endotoxin-initiated hemolysis

Immunopharmacology, 1999
Lysis via the newly discovered lectin pathway of complement activation is reviewed. Mannan-coated erythrocytes sensitized with MBL are lysed in human serum containing Mg-EGTA via the lectin pathway by a process which requires alternative pathway amplification.
Henry Gewurz, Yonghong Zhang, Thomas F. Lint, C Suankratay, Xiao-Hui Zhang   +4 more
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Lectins and protein traffic early in the secretory pathway

Biochemical Society Symposia, 2002
Lectins of the early secretory pathway are involved in selective transport of newly synthesized glycoproteins from the endoplasmic reticulum (ER) to the ER–Golgi intermediate compartment (ERGIC). The most prominent cycling lectin is the mannose-binding type I membrane protein ERGIC-53 (ERGIC protein of 53 kDa), a marker for the ERGIC, which functions ...
Hauri, Hans-Peter, Nufer, Oliver, Breuza, Lionel, Tekaya, Houchaima Ben, Liang, Lu   +4 more
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Derivatives of the lectin complement pathway in Lophotrochozoa

Developmental & Comparative Immunology, 2019
A plethora of non-overlapping immune molecular mechanisms in metazoans is the most puzzling issue in comparative immunobiology. No valid evolutionary retrospective on these mechanisms has been developed. In this study, we aimed to reveal the origin and evolution of the immune complement-like system in Lophotrochozoa.
openaire   +3 more sources

The role of ficolins in the lectin pathway of innate immunity

The International Journal of Biochemistry & Cell Biology, 2011
Ficolins are a family of oligomeric proteins consisting of an N-terminal collagen-like domain and a C-terminal globular fibrinogen-like domain. They are novel lectins that employ the fibrinogen-like domain as a functional domain. Ficolins specifically recognize N-acetyl compounds such as N-acetylglucosamine, components of bacterial and fungal cell ...
Misao Matsushita, Teizo Fujita, Yuichi Endo   +2 more
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Asparaginase inhibits the lectin pathway of complement activation

Molecular Immunology, 2018
Oncological treatment has been associated with an increased risk of infection, most often related to therapy-induced pancytopenia. However, limited research has been conducted on the effect of oncological therapy on the complement system, being part of the non-cellular innate immune system. This became the rationale for an observational clinical study (
Cathelijn E.M. Aarts, Taco W. Kuijpers, Angela M. Kamp, Mischa P. Keizer, M. D. van de Wetering, Diana Wouters, H.N. Caron   +6 more
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Activation of the lectin pathway in murine lupus nephritis

Molecular Immunology, 2005
In systemic lupus erythematosus (SLE), hypocomplementaemia and complement deposition have been described both in man and in experimental models. A major involvement of the classical pathway of complement activation has been demonstrated in this disease, however relatively little is known about the involvement of the lectin pathway.
Leendert A. Trouw, Jacques M.G.J. Duijs, Anja Roos, Ingeborg M. Bajema, Mohamed R. Daha, Michael Loos, Sven Wagner, Cees van Kooten, Marc A. Seelen   +8 more
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Association of Lectin Pathway Protein Levels and Genetic Variants Early after Injury with Outcomes after Severe Traumatic Brain Injury: A Prospective Cohort Study.

Journal of Neurotrauma, 2017
The lectin pathway of the complement system has been implicated in secondary ischemic/inflammatory injury after traumatic brain injury (TBI). However, previous experimental studies have yielded conflicting results, and human studies are scarce.
M. Osthoff, B. Walder, C. Delhumeau, M. Trendelenburg, N. Turck   +4 more
semanticscholar   +1 more source

The lectin pathway of complement: Advantage or disadvantage in HIV pathogenesis?

Clinical Immunology, 2014
The pattern recognition molecules of the lectin complement pathway are important components of the innate immune system with known functions in host-virus interactions. This paper summarizes current knowledge of how these intriguing molecules, including mannose-binding lectin (MBL), Ficolin-1, -2 and -3, and collectin-11 (CL-11) may influence HIV ...
Ballegaard, Vibe Cecilie Diederich, Haugaard, Anna Karen, Garred, P, Nielsen, Susanne Dam, Munthe-Fog, L   +4 more
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Relevance of the lectin pathway of complement in rheumatic diseases

2012
Due to its importance both in the clearance of pathogens that contribute as rheumatic etiological agents and in the disposal of apoptotic bodies and potential autoimmune initiators, deficiencies of the components of the lectin pathway of complement have been found to increase susceptibility and modulate the severity of most rheumatic disorders.
Isabela Goeldner, Angelica Beate Winter Boldt, de Messias-Reason Ij   +2 more
openaire   +3 more sources