Results 301 to 310 of about 159,204 (339)

Derivatives of the lectin complement pathway in Lophotrochozoa

Developmental & Comparative Immunology, 2019
A plethora of non-overlapping immune molecular mechanisms in metazoans is the most puzzling issue in comparative immunobiology. No valid evolutionary retrospective on these mechanisms has been developed. In this study, we aimed to reveal the origin and evolution of the immune complement-like system in Lophotrochozoa.
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Lectins and protein traffic early in the secretory pathway

Biochemical Society Symposia, 2002
Lectins of the early secretory pathway are involved in selective transport of newly synthesized glycoproteins from the endoplasmic reticulum (ER) to the ER–Golgi intermediate compartment (ERGIC). The most prominent cycling lectin is the mannose-binding type I membrane protein ERGIC-53 (ERGIC protein of 53 kDa), a marker for the ERGIC, which functions ...
Hauri, Hans-Peter, Nufer, Oliver, Breuza, Lionel, Tekaya, Houchaima Ben, Liang, Lu   +4 more
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Asparaginase inhibits the lectin pathway of complement activation

Molecular Immunology, 2018
Oncological treatment has been associated with an increased risk of infection, most often related to therapy-induced pancytopenia. However, limited research has been conducted on the effect of oncological therapy on the complement system, being part of the non-cellular innate immune system. This became the rationale for an observational clinical study (
Cathelijn E.M. Aarts, Taco W. Kuijpers, Angela M. Kamp, Mischa P. Keizer, M. D. van de Wetering, Diana Wouters, H.N. Caron   +6 more
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Activation of the lectin pathway in murine lupus nephritis

Molecular Immunology, 2005
In systemic lupus erythematosus (SLE), hypocomplementaemia and complement deposition have been described both in man and in experimental models. A major involvement of the classical pathway of complement activation has been demonstrated in this disease, however relatively little is known about the involvement of the lectin pathway.
Leendert A. Trouw, Jacques M.G.J. Duijs, Anja Roos, Ingeborg M. Bajema, Mohamed R. Daha, Michael Loos, Sven Wagner, Cees van Kooten, Marc A. Seelen   +8 more
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The lectin pathway of complement: Advantage or disadvantage in HIV pathogenesis?

Clinical Immunology, 2014
The pattern recognition molecules of the lectin complement pathway are important components of the innate immune system with known functions in host-virus interactions. This paper summarizes current knowledge of how these intriguing molecules, including mannose-binding lectin (MBL), Ficolin-1, -2 and -3, and collectin-11 (CL-11) may influence HIV ...
Ballegaard, Vibe Cecilie Diederich, Haugaard, Anna Karen, Garred, P, Nielsen, Susanne Dam, Munthe-Fog, L   +4 more
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Relevance of the lectin pathway of complement in rheumatic diseases

2012
Due to its importance both in the clearance of pathogens that contribute as rheumatic etiological agents and in the disposal of apoptotic bodies and potential autoimmune initiators, deficiencies of the components of the lectin pathway of complement have been found to increase susceptibility and modulate the severity of most rheumatic disorders.
Isabela Goeldner, Angelica Beate Winter Boldt, de Messias-Reason Ij   +2 more
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The mannan-binding-lectin pathway of the innate immune response

Current Opinion in Immunology, 2001
Dramatic progress has been achieved during the past year in our understanding of how the complement system is activated via the mannan-binding-lectin pathway. Surprising discoveries have changed our concepts of the complexes that are formed upon engagement of mannan-binding lectin with its serine proteases.
Gadjeva, M., Thiel, S., Jensenius, J.C.
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Significance of glomerular activation of the alternative pathway and lectin pathway in lupus nephritis

Lupus, 2011
The objective of the present study was to elucidate the association between glomerular complement depositions belonging to the alternative (AP) and lectin (LP) pathways, and clinical findings of lupus nephritis (LN). Immunofluorescence (IF) was performed on 17 LN patients using antibodies against factor B, factor H, properdin, mannose-binding lectin ...
Hiroyuki Inoshita, Nobuyuki Sato, Yasuhiko Tomino, Seiji Nagamachi, Satoshi Horikoshi, Hiroyuki Ohi, Misao Matsushita, A Toki, Isao Ohsawa, Masaya Ishii, Gaku Kusaba   +10 more
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An assay for the mannan-binding lectin pathway of complement activation

Journal of Immunological Methods, 2001
The mannan-binding lectin (MBL) pathway of complement activation has been established as the third pathway of complement activation. MBL is a carbohydrate-binding serum protein, which circulates in complex with serine proteases known as mannan-binding lectin associated serine proteases (MASPs).
Petersen, Steen Vang, Thiel, S, Jensen, L, Steffensen, R, Jensenius, J C   +4 more
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The Initiation Complexes of the Classical and Lectin Pathways

2006
Various antigen structures initiate the classical and the lectin pathways of complement activation. Multidomain modular proteases (C1r, C1s and MASPs) are involved in the initiation complexes of both pathways. Despite the identical domain organization of these serine proteases there are differences in their specificities and functions.
Géza Ambrus, Péter Závodszky, Zsolt Lőrincz, Péter Gál   +3 more
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