Results 71 to 80 of about 24,283,245 (285)

Turning-off Signaling by Siglecs, Selectins and Galectins: Chemical Inhibition of Glycan-dependent Interactions in Cancer

Frontiers in Oncology, 2016
Aberrant glycosylation, a common feature associated with malignancy, has been implicated in important events during cancer progression. Our understanding of the role of glycans in cancer has grown exponentially in the last few years, concurrent with ...
Alejandro Javier Cagnoni, Alejandro Javier Cagnoni, Juan Manuel Pérez Sáez, Gabriel Adrián Rabinovich, Gabriel Adrián Rabinovich, Karina Valeria Mariño   +5 more
doaj   +1 more source

Intrasplenic Thymus Organogenesis from Injectable Tissue Fragments Restores Functional T‐Cell Immunity

Advanced Science, EarlyView.
Clinical intramuscular thymus transplantation yields only short‐lived efficacy and marginal therapeutic benefits. Benefiting from the spleen's intrinsic strengths—rapid vascular perfusion, abundant developmental factors, and resident progenitors—the intrasplenic thymic grafts achieve robust thymic regeneration and substantial T‐cell reconstitution ...
Shaocong Wang, Zijian Zhang, Fulin Dai, Zhijie Yin, Zhen Xing, Yurong Li, Haochong Lei, Junfeng Zhang, Chunyan Liu, Yan Li, Lei Dong   +10 more
wiley   +1 more source

Variation of Neisseria gonorrhoeae lipooligosaccharide directs dendritic cell-induced T helper responses. [PDF]

PLoS Pathogens, 2009
Gonorrhea is one of the most prevalent sexually transmitted diseases in the world. A naturally occurring variation of the terminal carbohydrates on the lipooligosaccharide (LOS) molecule correlates with altered disease states.
Sandra J van Vliet, Liana Steeghs, Sven C M Bruijns, Medi M Vaezirad, Christian Snijders Blok, Jésus A Arenas Busto, Marcel Deken, Jos P M van Putten, Yvette van Kooyk   +8 more
doaj   +1 more source

C-type lectins do not act as functional receptors for filovirus entry into cells [PDF]

, 2010
Cellular C-type lectins have been reported to facilitate filovirus infection by binding to glycans on filovirus glycoprotein (GP). However, it is not clearly known whether interaction between C-type lectins and GP mediates all the steps of virus entry (i.
Keita Matsuno, Feldmann, Heinz, Ebihara, Hideki, Irimura, Tatsuro, Andrea Marzi, Matsuno, Keita, Osamu Noyori, Eri Nakayama, Takada, Ayato, Ayato Takada, Noyori, Osamu, Tatsuro Irimura, Nakayama, Eri, Heinz Feldmann, Hideki Ebihara, Marzi, Andrea   +15 more
core   +1 more source

Symbiont‐Induced HSP83 Establishes Two‐Tiered Control of Antifungal Immunity in an Invasive Beetle–Fungus Complex

Advanced Science, EarlyView.
In an invasive beetle–fungus complex, the mutualist Leptographium procerum induces host HSP83 and modulates Toll‐dependent antifungal immunity. HSP83 mediates two‐tiered control by associating with selected fungal recognition receptors and restraining Dorsal‐driven antimicrobial peptide transcription.
Qingtai Yang, Zhudong Liu, Yuqiao Yin, Jing Su, Dunyang Yu, Longsheng Xing, Zhen Zou, Le Kang, Jianghua Sun   +8 more
wiley   +1 more source

Transcriptome analyses to investigate symbiotic relationships between marine protists.

Frontiers in Microbiology, 2015
Rhizaria are an important component of oceanic plankton communities worldwide. A number of species harbour eukaryotic microalgal symbionts, which are horizontally acquired in the environment at each generation.
Sergio eBalzano, Erwan eCorre, Johan eDecelle, Roberto eSierra, Patrick eWincker, Corinne eDa Silva, Julie ePoulain, Jan ePawlowski, Fabrice eNot   +8 more
doaj   +1 more source

Immune escape through C-type lectins on dendritic cells

, 2002
Dendritic cells (DCs) detect different pathogens and elicit tailored anti-microbial immune responses. They express C-type lectins that recognise carbohydrate profiles on microorganisms, resulting in internalisation, processing and presentation ...
Anneke Engering, Geijtenbeek, Teunis B H, Engering, Anneke, Geijtenbeek, Teunis B. H., Yvette van Kooyk, Teunis B.H Geijtenbeek, van Kooyk, Yvette   +6 more
core   +1 more source

Reversing Macrophage Immunometabolic Dysfunction in Prolonged Infections Via a Glutaminolysis‐Fueled Restoration‐Based Hierarchically Selective Therapeutic System

Advanced Science, EarlyView.
A hierarchically selective immunotherapeutic nanoplatform, mGls@HEV‐MTP, selectively restores macrophage immunocompetence through GLS1‐mediated restoration of glutaminolysis‐fueled anaplerosis. Concurrently, it renders Staphylococcus aureus (S. aureus) more readily recognizable to the metabolically reprogrammed macrophages, thereby facilitating ...
Weinan Yang, Zihao An, Honglu Cai, Congsun Li, Jiaxuan Zou, Wushi Cui, Wentao Chen, Tao Zhang, Shicheng Wang, Zizhan Su, Jian Xiao, Tao Sun, Bin Hu, Min Cheng, Zhongru Gou, Jianbin Xu, An Liu, Haobo Wu   +17 more
wiley   +1 more source

“Sweet Talk”: Closing in on C Type Lectin Signaling [PDF]

Immunity, 2005
C type lectins recognize pathogens by binding to pathogen-specific carbohydrate residues. The finding reported by Rogers et al. (2005) in this issue of Immunity, that ligand binding by the C type lectin Dectin-1 leads to recruitment of the tyrosine kinase Syk and is critical to subsequent cytokine production by the cell, will surely inspire further ...
Meyer-Wentrup, F., Cambi, A., Adema, G.J., Figdor, C.G.   +3 more
openaire   +5 more sources

Binding and toxicity of plant lectins to insects [PDF]

, 2002
The toxicity of plant lectins to insects after oral ingestion was investigated by incorporating the proteins into insect diets. Bioassays carried out using an artificial diet system demonstrated that kidney bean (Phaseolus vulgaris) lectin (PHA) caused a
Woodhouse, Stephen David
core