Results 181 to 190 of about 38,146 (244)

Slit2/Robo Signaling Restores Diabetic Erectile Function via Neurovascular Remodeling

Andrology, EarlyView.
ABSTRACT Background Diabetes mellitus‐induced erectile dysfunction (DMED) is a common and debilitating vascular‐neurogenic complication of diabetes. The poor responsiveness of DMED patients to phosphodiesterase type‐5 inhibitors underscores the need for therapies capable of restoring both endothelial integrity and cavernous nerve function.
Sen Fu, Peng Hu, Zizhong Yang, Zhenghui Jin, Xiaoyu Zhu, Tao Wang, Jihong Liu, Kai Cui   +7 more
wiley   +1 more source

De Novo Assembly and Characterization of Venom Gland Transcriptome for <i>Rhabdophis lateralis</i>. [PDF]

Toxins (Basel)
Chen J, Liu Q, Tan S, Guo P, Du L.
europepmc   +1 more source

Therapeutic potential of natural products in cancer immunotherapy: Advances and challenges

British Journal of Pharmacology, EarlyView.
This review systematically outlines the mechanisms underlying tumour immunotherapy resistance and elucidates the role of natural products in enhancing therapeutic efficacy as immunomodulatory adjuvants. Abstract Immunotherapy has emerged as a clinically pivotal approach in cancer treatment, but its application remains limited to a small subset of ...
Rao Hu, Kaibin Dai, Zhensheng Lin, Mingfang Ye, Minfeng Chen, Xiaobo Li, Dongmei Zhang   +6 more
wiley   +1 more source

Galectin-3-A Multifunctional Molecule and a Key Player in Health and Disease. [PDF]

Molecules
Lupu Surlea A, Negreanu-Pirjol T, Olariu L, Negreanu-Pirjol BS, Jurja S, Lepadatu AC, Basa M, Rosoiu N.   +7 more
europepmc   +1 more source

Targeting KRAS for cancer therapy

British Journal of Pharmacology, EarlyView.
In recent years, therapeutics targeted against KRAS proto‐oncogene GTPase (KRAS)‐mutant cancers have seen significant progress. Herein we outline the biology and epidemiology of KRAS alterations at the lineage and allele levels, reviewing the clinical evidence for KRASG12C inhibition from the discovery of the recessive switch pocket to sotorasib ...
Jianlong Jia, Ruonan Liu, Tonia A. Adamide, Isis E. Fernandez, Georgios T. Stathopoulos   +4 more
wiley   +1 more source

Enzymatic tailoring of anionic glycans for characterizing lectin and antibody specificities in a microarray format. [PDF]

J Biol Chem
Nuschy L, Wilson IBH.
europepmc   +1 more source

The histone deacetylase inhibitor, suberoylanilide hydroxamic acid, restores blood–brain barrier integrity in a human stem cell‐based model of ischaemic stroke

British Journal of Pharmacology, EarlyView.
Ischaemic stroke is characterised by acute cerebrovascular occlusion and blood–brain barrier (BBB) breakdown. Our results indicated that the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) ameliorated the loss of BBB integrity, changed the morphology of brain endothelial cells, increased the level of basement membrane and ...
Anikó Szecskó, Koppány Párdi, Zuhao Cui, Gergő Porkoláb, Zsófia Hoyk, Csilla Kovács, Janet Folasade Adegbite, Virág Fodor, Nárcisz M. Cser, László Dér, Krisztina Nagy, Csilla Sajben, Roland Tengölics, Mária A. Deli, Szilvia Veszelka   +14 more
wiley   +1 more source

Glycan atlassing enables functional tracing of cell state. [PDF]

Nat Nanotechnol
Moonnukandathil Joseph D, Yurekli N, Fritsche S, Hashem R, Thoma OM, Larafa I, Boric T, Bielawski C, Almahayni K, Franze K, Waldner MJ, Möckl L.   +11 more
europepmc   +1 more source

CD93—An emerging vascular target in cancer therapy

British Journal of Pharmacology, EarlyView.
Abstract CD93 is a single‐pass transmembrane glycoprotein that belongs to the C‐type lectin domain group XIV family of proteins. Although it is known to be expressed in other cell types, namely, in some subsets of immune cells, CD93 is primarily expressed on endothelial cells, where it acts as a crucial regulator of angiogenesis.
Beatriz de Alves Pereira, Stefano Barbera, Roberta Lugano, Anna Dimberg   +3 more
wiley   +1 more source

The Entomotoxic Fungal Lectin <i>Marasmius oreades</i> Agglutinin Disrupts the Midgut Epithelium of Colorado Potato Beetle Larvae. [PDF]

J Agric Food Chem
Žigon P, Bogataj U, Praček S, Peternel T, Mrak P, Smodiš Škerl MI, Ladányi M, Karničar K, Fonović M, Panevska A, Skočaj M, Turk D, Žnidaršič N, Razinger J, Sabotič J.   +14 more
europepmc   +1 more source