Results 81 to 90 of about 24,283,061 (186)
, 2012 C-type lectins play crucial roles in innate immunity to recognize and eliminate pathogens efficiently. In the present study, two C-type lectins from shrimp Litopenaeus vannamei (designated as LvLectin-1 and LvLectin-2) were identified, and their ...
Yang, Jialong +6 more
core
Signaling pathways for transduction of the initial message of the glycocode into cellular responses [PDF]
, 1998 The sugar units of glycan structures store information and establish an alphabet of life. The language of the oligosaccharide coding units is deciphered by receptors such as lectins and the decoded message can be transduced by multiple signaling pathways.
Gabius, Hans-Joachim +2 more
core +1 more source
C-Type Lectin Receptors in Host Defense
Annual Review of ImmunologyC-type lectin receptors (CLRs) present on myeloid cells provide crucial signals for the induction of innate and adaptive immune responses. Their broad ligand specificity places them in a perfect position to sense both microbial intruders and signs of tissue injury or cell death.
Sonja I, Gringhuis +1 more
openaire +2 more sources
C-Type Lectins in Innate Immunity to Pathogens
Trends in Glycoscience and Glycotechnology, 2004 自然免疫系は感染に対する防御機構の最前線であり、防御機構の始動にとって非常に重要である。侵入した病原体は、樹状細胞 (Dendritic cell: DC) の表面に発現する Toll 様受容体やC型レクチン (CLR) などの病原体認識受容体によって認識される。DCが病原体由来の抗原を捕捉すると、DCには病原体を排除することに特化するような様々な変化が生じる。CLRは病原体の表面や分泌物に存在する糖抗原を特異的に捕捉し、その結果として抗原のプロセシングと提示が行われる。しかし、現在の実験事実はCLRが2つの機能を持つことを示唆している。すなわち、CLRは病原体由来抗原の認識に加え、糖付加を受けた自己抗原の認識機構としても機能しており、恒常性の制御と免疫寛容を誘導するというものである。興味深いことに、
Van Die, Irma +2 more
openaire +3 more sources
ParasiteCryptosporidium is a globally distributed zoonotic protozoan parasite that can cause severe diarrhea in humans and animals. L-type lectins are carbohydrate-binding proteins involved in multiple pathways in animals and plants, including protein ...
Zhang Xiaotian +9 more
doaj +1 more source
Detecção por abordagem molecular de uma lectina tipo-c na vieira Nodipecten nodosus (Bivalvia: pectinidae) [PDF]
, 2015 TCC(graduação) - Universidade Federal de Santa Catarina. Centro de Ciências Biológicas. Biologia.Lectinas tipo-C ou CTLs são proteínas dependentes de Ca2+, capazes de reconhecer açúcares específicos da superfície de células e causar sua aglutinação ...
Rizzato, Gabrielle Azevedo
core
Frontiers in Cellular and Infection Microbiology, 2016 Human CARD9 deficiency is an autosomal recessive primary immunodeficiency disorder caused by biallelic mutations in the gene CARD9, which encodes a signaling protein that is found downstream of many C-type lectin receptors (CLRs).
Rebecca A. Drummond, Michail S. Lionakis
doaj +1 more source
, 2016 Domain architecture of galectins, H-type lectins, R-type lectins, L-type lectins and calnexin-like proteins found in the transcriptome of A. vulgaris.
Tanja Bulat (3177186) +8 more
core +1 more source
Recent insights into structures and functions of C-type lectins in the immune system [PDF]
, 2015 The majority of the C-type lectin-like domains in the human genome likely to bind sugars have been investigated structurally, although novel mechanisms of sugar binding are still being discovered.
Taylor, Maureen E +3 more
core +1 more source
Nature Communications, 2019 Dengue virus (DENV) promotes leukocyte-platelet interactions that contribute to pathogenesis. Here, the authors report a role for C-type lectins CLEC2 and CLEC5A in platelet activation and NET formation and show that blockade of CLEC5A and TLR2 ...
Pei-Shan Sung +2 more
doaj +1 more source