Lectins, c-type - Open Access .click

Results 101 to 110 of about 24,283,245 (285)

Higher Complement C4 Gene Copy Number Constitutes a Shared Genetic Risk Factor for Giant Cell Arteritis and IgA Vasculitis

Arthritis &Rheumatology, EarlyView.
Objective Low copy number (CN) of complement C4 isoforms and high CN of retroviral HERV‐K elements are known risk factors for many immune‐mediated inflammatory diseases (IMIDs), often showing sex‐biased effects. Here, we assessed whether CN variation within the C4 gene contributes to giant cell arteritis (GCA) and IgA vasculitis (IgAV), two complex ...
Laura Martínez‐Gutiérrez +295 more
wiley +1 more source

A newly identified three-domain C-type lectin associated with blood feeding in the tick Ixodes ricinus

Ticks and Tick-Borne Diseases
Ixodes ricinus ticks are widely distributed throughout Europe and represent major vectors of tick-borne encephalitis virus and the Lyme borreliosis agent Borrelia burgdorferi sensu lato.
Kateryna Kotsarenko +10 more
doaj +1 more source

Characterization of C-type lectins reveals an unexpectedly limited interaction between Cryptococcus neoformans spores and Dectin-1.

PLoS ONE, 2017
Phagocytosis by innate immune cells is an important process for protection against multiple pathologies and is particularly important for resistance to infection.
Naomi M Walsh +4 more
doaj +1 more source

Interaction of the capsular polysaccharide A from Bacteroides fragilis with DC-SIGN on human dendritic cells is necessary for its processing and presentation to T cells.

Frontiers in Immunology, 2013
The zwitterionic capsular polysaccharide A (PSA) of Bacteroides fragilis is the first carbohydrate antigen described to be presented in major histocompatibility complex (MHC) class II for the induction of CD4+ T cell responses.
Karien eBloem +6 more
doaj +1 more source

Homocitrullinated Peptides Drive Pro‐Inflammatory T Cell Responses in a Humanized Mouse Model of Rheumatoid Arthritis

Arthritis &Rheumatology, EarlyView.
Objective Anti‐homocitrullinated protein/peptide antibodies are specific to rheumatoid arthritis (RA) and predictive of worse prognosis, suggesting a pathogenic role for autoreactivity to homocitrullinated peptides (HomoCitP). However, T cell responses to HomoCitP remain largely unexplored.
Sofya Ulanova +6 more
wiley +1 more source

Two C-type lectins from shrimp Litopenaeus vannamei that might be involved in immune response against bacteria and virus

, 2012
C-type lectins play crucial roles in innate immunity to recognize and eliminate pathogens efficiently. In the present study, two C-type lectins from shrimp Litopenaeus vannamei (designated as LvLectin-1 and LvLectin-2) were identified, and their ...
Yang, Jialong +6 more
core

Signaling pathways for transduction of the initial message of the glycocode into cellular responses [PDF]

, 1998
The sugar units of glycan structures store information and establish an alphabet of life. The language of the oligosaccharide coding units is deciphered by receptors such as lectins and the decoded message can be transduced by multiple signaling pathways.
Gabius, Hans-Joachim, Villalobo, Antonio, Villalobo, A. +2 more
core +1 more source

From Interferon Signature to the Clinical Landscape: Type I Interferonopathies

Arthritis &Rheumatology, EarlyView.
Objective TypeI interferonopathies are heterogeneous diseases driven by dysregulated type I interferon (IFN‐I) signaling. Diagnosis is challenging due to clinical/molecular variability and the need for IFN‐I quantification. The aim of this study was to characterize the clinical, immunologic, genetic, molecular profiles of patients with suspected ...
Ismail Yaz +13 more
wiley +1 more source

C-Type Lectin Receptors in Host Defense

Annual Review of Immunology
C-type lectin receptors (CLRs) present on myeloid cells provide crucial signals for the induction of innate and adaptive immune responses. Their broad ligand specificity places them in a perfect position to sense both microbial intruders and signs of tissue injury or cell death.
Sonja I, Gringhuis, Teunis B H, Geijtenbeek +1 more
openaire +2 more sources

C-Type Lectins in Innate Immunity to Pathogens

Trends in Glycoscience and Glycotechnology, 2004
自然免疫系は感染に対する防御機構の最前線であり、防御機構の始動にとって非常に重要である。侵入した病原体は、樹状細胞 (Dendritic cell: DC) の表面に発現する Toll 様受容体やC型レクチン (CLR) などの病原体認識受容体によって認識される。DCが病原体由来の抗原を捕捉すると、DCには病原体を排除することに特化するような様々な変化が生じる。CLRは病原体の表面や分泌物に存在する糖抗原を特異的に捕捉し、その結果として抗原のプロセシングと提示が行われる。しかし、現在の実験事実はCLRが2つの機能を持つことを示唆している。すなわち、CLRは病原体由来抗原の認識に加え、糖付加を受けた自己抗原の認識機構としても機能しており、恒常性の制御と免疫寛容を誘導するというものである。興味深いことに、
Van Die, Irma, Engering, Anneke, Van Kooyk, Yvette +2 more
openaire +3 more sources

c-type lectins
c-type lectin
innate immunity

immunologic diseases
allergy
lectin

lectins
agglutination