ASGR2 AND CLEC12A C TYPE LECTINS: NEW PLAYERS IN GLIOBLASTOMA IMMUNOSUPPRESSIVE NETWORKS
BACKGROUND-AIM Glioblastoma (GBM) is the most fathal brain tumor in adults with poor survival and no effective treatment. Dissecting immunosuppressive mechanisms in GBM is crucial to identify novel therapeutic targets.
A. Santoro +9 more
core
Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future
Medicinal Research Reviews, EarlyView.ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley +1 more source
Synergistic Regulation of Tumor Immunity by Integrins and Lectins: From Molecular Mechanisms to Dual-Targeted Therapy. [PDF]
Int J Mol SciLiu R +10 more
europepmc +1 more source
Medicinal Research Reviews, EarlyView.ABSTRACT Chitinase‐3‐like‐1 (CHI3L1, also known as YKL‐40) has been recognized as a biomarker of inflammation and tissue remodeling and has now emerged as a pseudoenzymatic immune checkpoint. Recent structural, immunological, and translational studies redefine it as an active regulator of immune suppression rather than a passive disease marker. Despite
Kirti Upmanyu +2 more
wiley +1 more source
Reversible Modulation of Glycan Recognition in C-Type Lectins by Calcium/Lanthanide Exchange. [PDF]
ChembiochemValverde P +8 more
europepmc +1 more source
Synthesis of a multivalent α-1,2-mannobiose ligand for targeting C-type lectins
The importance of lectins in biological processes such as pathogen recognition, cell adhesion, and cell recognition is well documented. C-Type lectins, which require calcium for binding, play an important role in the innate immune response by engaging ...
Snyder, Nicole L. +2 more
core +1 more source
Magnetic Resonance in Chemistry, EarlyView.The impact of temperature on the analysis of STD NMR ligand epitope mapping has been thoroughly investigated. For protein–ligand complexes under fast exchange kinetics, a negligible temperature effect is observed. For the intermediate exchange regime, VT‐STD NMR allows to obtain better discriminated epitope mappings, hence enabling the accurate ...
Gabriel Rocha +3 more
wiley +1 more source
Transmembrane lectins in cancer immunity: emerging drivers of myeloid-mediated immunosuppression. [PDF]
Front ImmunolTrindade G, Palma AS, Brito C.
europepmc +1 more source
Assessment of Lectin Staining Biomarkers for GNE Myopathy Gene Therapy
Muscle &Nerve, EarlyView.ABSTRACT Introduction/Aims GNE myopathy (GNEM) is a rare, autosomal recessive disorder caused by mutations in the UDP‐N‐acetylglucosamine (GlcNAc) 2‐epimerase/N‐acetylmannosamine (ManNAc) kinase (GNE) gene, which encodes a required enzyme for sialic acid (SA) biosynthesis.
Kristina M. Sattler +8 more
wiley +1 more source
A N-Acetyl-D-Glucosamine-Binding C-Type Lectin in the Cutaneous Mucus of Chub Mackerel, Scomber japonicus, Agglutinates Pathogenic Bacteria. [PDF]
Microbiol ImmunolTsutsui S +3 more
europepmc +1 more source