Results 141 to 150 of about 24,283,245 (285)
Covalent Activation of the C‐type Lectin DC‐SIGN
Angewandte Chemie International EditionAbstract Dendritic cell‐specific intercellular adhesion molecule‐3‐grabbing non‐integrin (DC‐SIGN) is a C‐type lectin receptor expressed on antigen‐presenting cells, crucial for pathogen recognition and immune modulation. The shallow and polar carbohydrate binding site of DC‐SIGN presents challenges for ligand design.
Lefèbre, Jonathan +9 more
openaire +5 more sources
International Journal of Gynecology &Obstetrics, EarlyView.Abstract Objective To investigate the role of ST3 β‐galactoside α‐2,3‐sialyltransferase 1 (ST3Gal1) and vascular endothelial growth factor receptor 2 (VEGF‐R2) in endometrioid‐type epithelial ovarian cancer (E‐OC) because aberrant α2,3‐sialylation mediated by ST3Gal1 and VEGF‐R2‐related angiogenesis is linked with tumor progression. Methods ST3Gal1 and
Wei‐Ting Chao +5 more
wiley +1 more source
Secondary Sites of the C‐type Lectin‐Like Fold
Chemistry – A European JournalAbstractC‐type lectins are a large superfamily of proteins involved in a multitude of biological processes. In particular, their involvement in immunity and homeostasis has rendered them attractive targets for diverse therapeutic interventions. They share a characteristic C‐type lectin‐like domain whose adaptability enables them to bind a broad ...
Lefèbre, Jonathan +3 more
openaire +5 more sources
Functional comparison of the mouse DC-SIGN, SIGNR1, SIGNR3 and Langerin, C-type lectins [PDF]
, 2004 The mouse (m) DC-SIGN family consists of several homologous type II transmembrane proteins located in close proximity on chromosome 8 and having a single carboxyl terminal carbohydrate recognition domain.
Yashima, Yusuke +2 more
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iMeta, EarlyView.The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li +29 more
wiley +1 more source
iNew Medicine, EarlyView.ABSTRACT Human papillomavirus (HPV) is a double‐stranded DNA virus that infects human skin and mucosal tissues exclusively. The German scientist Harald zur Hausen was awarded the 2008 Nobel Prize in Physiology or Medicine for his discovery of the link between HPV infection and cervical cancer.
Fang Zhu +5 more
wiley +1 more source
, 2018 Several protein groups including C-type lectin-like proteins constitute many snake venoms. Snake venom C-type lectins have been shown to inhibit platelet function, coagulation factors, cell adhesion, cell migration and cell invasion.
Walls, Robert I.
core
iNew Medicine, EarlyView.ABSTRACT Objective In the cancer microenvironment, stromal and immune cells hold clinical importance. In lung squamous cell carcinoma (LSCC), the aim of this study was to find immune‐linked gene expression that has prognostic pertinence. Methods From the Cancer Genome Atlas, this study obtained the LSCC gene expression profile.
Weijia Jiang +5 more
wiley +1 more source
Use of Natural and Synthetic Glycolipid Libraries in Defining Lectins from Pathogens
, 2007 Lectins: Analytical Technologies covers both analytical and biological aspects of lectins (functional carbohydrate (complex sugar) recognition proteins) and provides researchers in the field with a resource containing background information and 'look-up'
Natunen, Jari +4 more
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Journal of Applied Toxicology, EarlyView.ABSTRACT Moringa oleifera Lam. seeds contain WSMoL, a lectin previously studied for toxicity and pharmacological effects. In this study, we investigated WSMoL (10, 25, or 50 mg/kg i.p.) for acute and 14‐day repeated‐dose toxicity, as well as genotoxicity, in Swiss mice.
Alícia Natalie Silva dos Santos +10 more
wiley +1 more source