Results 171 to 180 of about 1,772,176 (315)

Secondary Sites of the C‐type Lectin‐Like Fold

Chemistry – A European Journal
AbstractC‐type lectins are a large superfamily of proteins involved in a multitude of biological processes. In particular, their involvement in immunity and homeostasis has rendered them attractive targets for diverse therapeutic interventions. They share a characteristic C‐type lectin‐like domain whose adaptability enables them to bind a broad ...
Lefèbre, Jonathan, Falk, Torben, Ning, Yunzhan, Rademacher, Christoph   +3 more
openaire   +3 more sources

Harnessing chimeric antigen receptor macrophages against solid tumors

Cancer Communications, EarlyView.
Abstract Macrophages are prevalent in multiple tumors and exhibit diverse and potent functional activities. Therapeutic reprogramming of macrophage phenotypes represents a promising strategy for cancer immunotherapy. Engineering chimeric antigen receptors (CARs) to endow macrophages with anti‐tumor capacities demonstrated encouraging efficacy ...
Mengru Wang, Zhen Qin, Xiu‐Wu Bian, Yu Shi   +3 more
wiley   +1 more source

Editorial: Lectins and Their Ligands in Shaping Immune Responses

Frontiers in Immunology, 2019
Bernd Lepenies, Roland Lang
doaj   +1 more source

CD24 is a promising immunotherapeutic target for enhancing efficacy of third‐generation EGFR‐TKIs on EGFR‐mutated lung cancer

Cancer Communications, EarlyView.
Abstract Background Third‐generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) show initial efficacy in EGFR‐mutated lung cancer, but residual disease persists. This study aimed to investigate cluster of differentiation 24 (CD24) as a translational immunotherapeutic target for enhancing third‐generation EGFR‐TKI efficacy.
Jiaqi Liang, Guoshu Bi, Xiaolong Huang, Zhijie Xu, Yiwei Huang, Yunyi Bian, Guangyao Shan, Wei Guo, Yuanliang Yan, Qihai Sui, Xiaodong Yang, Zhencong Chen, Tao Lu, Huan Zhang, Qun Wang, Wei Jiang, Cheng Zhan   +16 more
wiley   +1 more source

Biotechnological Potential of Seaweeds from Bahia, Brazil: Metabolomic insights, Photoprotection and Antioxidant Activity

Chemistry &Biodiversity, EarlyView.
Chemical profile, photoprotective, and antioxidant potential of Padina sp., Caulerpa sertularioides, and Solieria filiformis collected in Bahia, Brazil. ABSTRACT Seaweeds have wide biotechnological applications. This study evaluated the chemical profile, photoprotective, and antioxidant potential of Padina sp., Caulerpa sertularioides, and Solieria ...
Keila Almeida Santana, Isadora de Jesus da Silva, Victor Pena Ribeiro, José Marcos de Castro Nunes, Hosana Maria Debonsi, Ian Castro‐Gamboa, Lorena Rigo Gaspar, Gustavo Souza dos Santos, Aníbal de Freitas Santos Júnior   +8 more
wiley   +1 more source

C‐6‐Modified 2‐F‐Fucose Derivatives as Inhibitors of Fucosyltransferases

ChemBioChem, EarlyView.
A series of C6‐modified guanosine‐diphosphate‐2‐F‐fucose analogs and corresponding prodrugs are designed, synthesized, and biologically evaluated as inhibitors of cellular fucosylation. Certain analogs potently inhibit fucosyltransferases (FUT) FUT1, 3, 6, and 9 while showing minimal activity for FUT8, highlighting the potential for selective FUT ...
Yanyan Liu, Geert‐Jan Boons
wiley   +1 more source

Effect of Genotype on the Properties of Flours and Protein Isolates Derived From Wrinkled and Round Peas

Cereal Chemistry, EarlyView.
ABSTRACT Background and Objectives This study evaluated the effect of seed shape on the composition, functional, and quality properties of pea flours and protein isolates. Wrinkled‐seed (WPAs) and round‐seed (RPA) pea accessions were selected from a genome‐wide association study panel.
Cassia Galves, Krishna Kishore Gali, Thomas D. Warkentin, James House, Michael Nickerson   +4 more
wiley   +1 more source

Azobenzene‐Based Glycomacrocycles: Synthesis, Photoisomerization, and Photomodulation of Liquid Crystal Helical Pitch with Helix Inversion

Chemistry – A European Journal, EarlyView.
Macrocyclic glycoazobenzenes: Four new azobenzene‐functionalized glycomacrolactones bearing different substituents on the glucopyranoside ring have been synthesized. These photoswitchable chiral macrocycles behave as chiral dopants of NLCs, with an amplification of helix upon E to Z photoisomerization and enforcement of HTP at Z‐rich state.
Gaoyu Li, Reo Hatano, Stéphane Maisonneuve, Ken‐ichi Iimura, Yuna Kim, Juan Xie   +5 more
wiley   +1 more source

Mosquito C-type lectins maintain gut microbiome homeostasis

Nature Microbiology, 2016
X. Pang, Xiaoping Xiao, Yang Liu, Rudian Zhang, Jianying Liu, Qiyong Liu, Penghua Wang, G. Cheng   +7 more
semanticscholar   +1 more source

Conserved Phosphorylation of the Myosin1e TH1 Domain Impacts Membrane Association and Function in Yeast and Worms

Cytoskeleton, EarlyView.
ABSTRACT Cells have an intrinsic ability to rapidly respond to environmental change to regulate cell cycle progression and membrane organisation, thereby affecting cell growth and division. The actin cytoskeleton is a highly dynamic complex of proteins that can rapidly reorganise to change the growth pattern of a cell.
Holly R. Brooker, Karen Baker, Marina Ezcurra, Philippe P. Laissue, Lin Wang, Michael A. Geeves, Jennifer M. Tullet, Daniel P. Mulvihill   +7 more
wiley   +1 more source