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Genomic analysis of C-type lectins
Biochemical Society Symposia, 2002Many biological effects of complex carbohydrates are mediated by lectins that contain discrete carbohydrate-recognition domains. At least seven structurally distinct families of carbohydrate-recognition domains are found in lectins that are involved in intracellular trafficking, cell adhesion, cell–cell signalling, glycoprotein turnover and innate ...
Kurt, Drickamer, Andrew J, Fadden
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2014
C-type lectins belong to a superfamily of receptors that share structural homology in their carbohydrate recognition domains and often bind to carbohydrates in a Ca-dependent fashion. Whereas endocytic C-type lectin receptors (CLRs) trigger the receptor-mediated endocytosis of soluble ligands, myeloid CLRs in innate immunity act as pattern recognition ...
Timo Johannssen +3 more
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C-type lectins belong to a superfamily of receptors that share structural homology in their carbohydrate recognition domains and often bind to carbohydrates in a Ca-dependent fashion. Whereas endocytic C-type lectin receptors (CLRs) trigger the receptor-mediated endocytosis of soluble ligands, myeloid CLRs in innate immunity act as pattern recognition ...
Timo Johannssen +3 more
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Current Opinion in Structural Biology, 1999
Carbohydrate-recognition domains of C-type (Ca2+-dependent) animal lectins serve as prototypes for an important family of protein modules. Only some domains in this family bind Ca2+ or sugars. A comparison of recent structures of C-type lectin-like domains reveals diversity in the modular fold, particularly in the region associated with Ca2+ and sugar ...
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Carbohydrate-recognition domains of C-type (Ca2+-dependent) animal lectins serve as prototypes for an important family of protein modules. Only some domains in this family bind Ca2+ or sugars. A comparison of recent structures of C-type lectin-like domains reveals diversity in the modular fold, particularly in the region associated with Ca2+ and sugar ...
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Insect C-Type Lectins in Microbial Infections
2020C-type lectins (CTLs) are a family of carbohydrate-recognition domain (CRD)-containing proteins that bind to ligands in a calcium-dependent manner. CTLs act as important components of insect innate immune responses, such as pattern recognition, agglutination, encapsulation, melanization, phagocytosis and prophenoloxidase activation, as well as gut ...
Yibin, Zhu, Xi, Yu, Gong, Cheng
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C-type lectin receptors in antifungal immunity
Trends in Microbiology, 2008Fungal infections represent a significant health burden, especially in immunocompromised individuals, yet many of the underlying immunological mechanisms involved in the recognition and control of these pathogens are unclear. The identification of the Toll-like receptors (TLRs) has shed new insights on innate microbial recognition and the initiation of
Janet A, Willment, Gordon D, Brown
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2012
Historically the C-Type lectins (CLEC) or C-type lectin receptors (CLR) form a family of Ca2+ dependent carbohydrate binding proteins which have a common sequence motif of 115–130 amino acid residues, referred to as the carbohydrate recognition domain (CRD). The C-type designation is from their requirement for calcium for binding.
Anita Gupta, G. S. Gupta
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Historically the C-Type lectins (CLEC) or C-type lectin receptors (CLR) form a family of Ca2+ dependent carbohydrate binding proteins which have a common sequence motif of 115–130 amino acid residues, referred to as the carbohydrate recognition domain (CRD). The C-type designation is from their requirement for calcium for binding.
Anita Gupta, G. S. Gupta
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C-Type Lectin Receptors in Antifungal Immunity
2020Most fungal species are harmless to humans and some exist as commensals on mucocutaneous surfaces. Yet many fungi are opportunistic pathogens, causing life-threatening invasive infections when the immune system becomes compromised. The fungal cell wall contains conserved pathogen-associated molecular patterns (PAMPs), which allow the immune system to ...
Christina, Nikolakopoulou +2 more
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C-Type Lectin Receptors Orchestrate Antifungal Immunity
Future Microbiology, 2013Fungal infections are an emerging threat for human health. A coordinated host immune response is fundamental for successful elimination of an invading fungal microbe. A panel of C-type lectin receptors expressed on antigen-presenting dendritic cells enable innate recognition of fungal cell wall carbohydrates and tailors adaptive responses via the ...
Brigitte A, Wevers +2 more
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Insect C-type lectins in innate immunity
Developmental & Comparative Immunology, 2018C-type lectins (CTLs) are a family of proteins that contain characteristic modules of carbohydrate-recognition domains (CRDs) and they possess the binding activity to ligands in a calcium-dependent manner. CTLs play important roles in animal immune responses, and in insects, they are involved in opsonization, nodule formation, agglutination ...
Xiaofeng Xia +3 more
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Myeloid C-type lectins in innate immunity
Nature Immunology, 2006C-type lectins expressed on myeloid cells comprise a family of proteins that share a common structural motif, and some act as receptors in pathogen recognition. But just as the presence of leucine-rich repeats alone is not sufficient to define a Toll-like receptor, the characterization of C-type lectin receptors in innate immunity requires the ...
Robinson, Matthew J +4 more
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