Results 271 to 280 of about 1,772,176 (315)

Endocrine Resistance Score Based on Three Key Genes Predicts Prognosis and Reveals Potential Therapeutic Targets for ER+HER2− Breast Cancer

Cell Proliferation, EarlyView.
We generated endocrine‐resistant BC cell lines and identified CLEC3A, PCDH10, and ST3GAL1 as key endocrine‐resistant genes. More importantly, we validated their role in mediating resistance through PI3K‐AKT signalling and developed a predictive ERS with strong clinical relevance.
Liqin Ping, Lewei Zhu, Nian Chen, Xikun Liu, Jirui Zhong, Xiaoqing Sun, Hailin Tang, Kaiming Zhang   +7 more
wiley   +1 more source

Aberrant glycosylation patterns as potential biomarkers for diagnosis and disease progression in bullous pemphigoid. [PDF]

Front Immunol
Miao H, Yang J, Bai Y, Shen S, Li X, Yue L, Wang G, Dang E.   +7 more
europepmc   +1 more source

Status quo and future developments in the diagnosis and treatment of hereditary angioedema

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Hereditary angioedema (HAE) is a rare hereditary disease characterized by edema, which can be life‐threatening in case of swelling in the larynx. The most common form of HAE is caused by a mutation of the SERPING1 gene and is characterized by a deficiency (type I) or loss of function (type II) of the C1 inhibitor (C1‐INH), leading to excessive ...
Andreas Recke
wiley   +1 more source

Cell membrane glycan contents are biochemical factors that constitute a kinetic barrier to viral particle uptake in a protein-nonspecific manner. [PDF]

Elife
Kaizuka Y, Machida R.
europepmc   +1 more source

Medial septum parvalbumin‐expressing inhibitory neurons are impaired in a mouse model of Dravet syndrome

Epilepsia, EarlyView.
Abstract Objective Dravet syndrome (DS) is a severe neurodevelopmental disorder caused by pathogenic variants in the SCN1A gene, which encodes the voltage‐gated sodium channel Nav1.1 α subunit. Experiments in animal models of DS—including the haploinsufficient Scn1a+/− mouse—have identified impaired excitability of interneurons in the hippocampus and ...
Limei Zhu, Yiannos Demetriou, Joseph Barden, Juan Disla, Meiling Zhao, Joanna Mattis   +5 more
wiley   +1 more source

Novel Lectins from <i>Bauhinia</i> with Differential <i>N-</i>Glycan Binding Profiles. [PDF]

ACS Omega
Osterne VJS, Lima LD, Oliveira MV, Pinto-Junior VR, Neto CC, Correia SEG, Suarez C, Van Damme EJM, Serna S, Reichardt NC, Nascimento KS, Cavada BS.   +11 more
europepmc   +1 more source

Blood group O expression in normal tissues and tumors

The FEBS Journal, EarlyView.
The H antigen (O blood group), the precursor to A and B blood groups, is expressed on human erythrocytes. Two novel monoclonal antibodies generated using sea lamprey immunization, Tn4‐31L and OmcFL3‐02, specifically detect the H antigen on glycan microarrays, glycoproteins, and human cells.
Ea Kristine Clarisse Tulin, Lukas Muerner, Tanya R. McKitrick, Catherine A. Tilton, Lauren E. Pepi, Tianwei Jia, Maxence Noel, Leon Y. Zheng, Sean R. Stowell, Stephan von Gunten, Jamie Heimburg‐Molinaro, Richard D. Cummings   +11 more
wiley   +1 more source

Multi-omics profiling of Nanhaia speciosa and Nanhaia fordii: insights into lectin dynamics, nodulation, and triterpenoid saponin biosynthesis. [PDF]

BMC Biol
Li Z, Wang J, Zhang J, Fu Y, Jing Y, Huang B, Wu H, Meng C, Xu L.   +8 more
europepmc   +1 more source

Exploring the Structural Diversity and Biotechnological Potential of the Rhodophyte Phycolectome. [PDF]

Mar Drugs
Rodrigues ÉF, Verza FA, Nishimura FG, Beleboni RO, Hermans C, Janssens K, De Mol ML, Hulpiau P, Marins M.   +8 more
europepmc   +1 more source

REG3A and IL22 have opposite effects on fat accumulation in the liver in a high-fat diet. [PDF]

Sci Rep
Nogues EB, Auger S, Agus A, Bruneau A, Chain F, Graci L, Langella P, Chatel JM.   +7 more
europepmc   +1 more source