Results 71 to 80 of about 38,146 (244)

C-Type Lectins in Innate Immunity to Pathogens

Trends in Glycoscience and Glycotechnology, 2004
自然免疫系は感染に対する防御機構の最前線であり、防御機構の始動にとって非常に重要である。侵入した病原体は、樹状細胞 (Dendritic cell: DC) の表面に発現する Toll 様受容体やC型レクチン (CLR) などの病原体認識受容体によって認識される。DCが病原体由来の抗原を捕捉すると、DCには病原体を排除することに特化するような様々な変化が生じる。CLRは病原体の表面や分泌物に存在する糖抗原を特異的に捕捉し、その結果として抗原のプロセシングと提示が行われる。しかし、現在の実験事実はCLRが2つの機能を持つことを示唆している。すなわち、CLRは病原体由来抗原の認識に加え、糖付加を受けた自己抗原の認識機構としても機能しており、恒常性の制御と免疫寛容を誘導するというものである。興味深いことに、
Van Die, Irma, Engering, Anneke, Van Kooyk, Yvette   +2 more
openaire   +3 more sources

Animal models of idiopathic membranous nephropathy: Recent advances and future perspectives

Animal Models and Experimental Medicine, EarlyView.
This review focuses on the evolution of idiopathic membranous nephropathy (IMN) animal models from traditional approaches (Heymann nephritis, C‐BSA, APA) to antigen‐specific models (PLA2R, THSD7A), critically evaluating their advances and limitations in replicating human IMN pathology.
Qiuying Liu, Huixian Bian, Jianhua Liu, Lina Wu, Zhijie Zhang, Hongli Zhao, Xiaosong Qin   +6 more
wiley   +1 more source

C-type lectins in immunity: recent developments

Current Opinion in Immunology, 2015
C-type lectin receptors (CLRs) comprise a large superfamily of proteins, which recognise a diverse range of ligands, and are defined by the presence of at least one C-type lectin-like domain (CTLD). Of particular interest are the single extracellular CTLD-containing receptors of the 'Dectin-1' and 'Dectin-2' clusters, which associate with signalling ...
Dambuza, Ivy M, Brown, Gordon D
openaire   +3 more sources

Crotacetin, a novel snake venom C-type lectin, is homolog of convulxin

Journal of Venomous Animals and Toxins including Tropical Diseases, 2005
Snake venom (sv) C-type lectins encompass a group of hemorrhagic toxins, which are able to interfere with hemostasis. They share significant similarity in their primary structures with C-type lectins of other animals, and also present a conserved ...
G. Rádis-Baptista, F. B. M. B. Moreno, L. L. Nogueira, A. M. C. Martins, D. O. Toyama, M. H. Toyama, W. F. Azevedo Jr, B. S. Cavada, T. Yamane   +8 more
doaj   +1 more source

Comparison of Receptor‐Mediated Endocytosis and Its Application to Enhance DNA Transfection by TFAMoplex

Advanced NanoBiomed Research, EarlyView.
We developed an assay to distinguish cellular binding from internalization. Compatible with microscopy and high‐throughput screening, the method identifies ligand‐mediated uptake. Applying top candidates to a protein‐based DNA carrier enhanced transfection efficiency, providing a rational strategy to improve non‐viral gene delivery systems.
David Scherer, Steffen Honrath, Jonas Kurmann, Alexander Klipp, Finn Brigger, Jean‐Christophe Leroux   +5 more
wiley   +1 more source

The C‐type lectin‐like domain superfamily

The FEBS Journal, 2005
The superfamily of proteins containing C‐type lectin‐like domains (CTLDs) is a large group of extracellular Metazoan proteins with diverse functions. The CTLD structure has a characteristic double‐loop (‘loop‐in‐a‐loop’) stabilized by two highly conserved disulfide bridges located at the bases of the loops, as well as a set of conserved hydrophobic and
Zelensky, Alex, Gready, Jill
openaire   +3 more sources

Morphophysiological dynamics of the proximal post‐testicular ducts in Crotalus durissus Linnaeus, 1758 (Squamata: Viperidae)

The Anatomical Record, EarlyView.
Abstract The organization and function of reptilian excurrent ducts remain poorly characterized, particularly in Neotropical snakes. We provide the first integrative morphological, histochemical, immunohistochemical, and ultrastructural analysis of the proximal post‐testicular ducts of Crotalus durissus across reproductive stages.
Flávia Cappuccio de Resende, Gustavo Caldeira Cotta, Clara d' Ávila Fonseca Paiva de Paula Freitas, Leonardo Carvalho, Heloísa Helena Marques Oliveira, Victória Gomes Carvalho Silva, Lívia de Fátima Moreira Silva, Luciana Maria Silva, Samyra Maria dos Santos Nassif Lacerda, Guilherme Mattos Jardim Costa   +9 more
wiley   +1 more source

C-Type Lectin Receptors

, 2016
C-type lectins, originally defined as proteins binding carbohydrates in a Ca(2+)-dependent manner, form a large family containing soluble and membrane-bound proteins. Among them, those expressed on phagocytes and working as pathogen pattern-recognition receptors were designated as C-type lectin receptors (CLRs), in accordance with Toll-like receptors ...
openaire   +1 more source

Characterization of C-type lectins reveals an unexpectedly limited interaction between Cryptococcus neoformans spores and Dectin-1.

PLoS ONE, 2017
Phagocytosis by innate immune cells is an important process for protection against multiple pathologies and is particularly important for resistance to infection.
Naomi M Walsh, Marcel Wuthrich, Huafeng Wang, Bruce Klein, Christina M Hull   +4 more
doaj   +1 more source

Interaction of the capsular polysaccharide A from Bacteroides fragilis with DC-SIGN on human dendritic cells is necessary for its processing and presentation to T cells.

Frontiers in Immunology, 2013
The zwitterionic capsular polysaccharide A (PSA) of Bacteroides fragilis is the first carbohydrate antigen described to be presented in major histocompatibility complex (MHC) class II for the induction of CD4+ T cell responses.
Karien eBloem, Karien eBloem, Juan J Garcia-Vallejo, Ilona M Vuist, Brian eCobb, Sandra J van Vliet, Yvette eVan Kooyk   +6 more
doaj   +1 more source