Lectins, c-type - Open Access .click

Results 91 to 100 of about 39,010 (245)

Fasting and Refeeding Mediated Phospholipid Remodeling Plays an Important Role in Improving Meat Quality of Aged Laying Hens

Animal Research and One Health, EarlyView.
ABSTRACT This study explored fasting‐induced physiological remodeling effects on meat quality in aged laying hens. Fasting for 15 days (F15) significantly reduced abdominal fat, intermuscular fat width, subcutaneous fat thickness, and liver index versus pre‐fasting (F0) (p < 0.05), which recovered post‐refeeding.
Xiaoran Zhang +8 more
wiley +1 more source

C-Type Lectin Receptors in Host Defense

Annual Review of Immunology
C-type lectin receptors (CLRs) present on myeloid cells provide crucial signals for the induction of innate and adaptive immune responses. Their broad ligand specificity places them in a perfect position to sense both microbial intruders and signs of tissue injury or cell death.
Sonja I, Gringhuis, Teunis B H, Geijtenbeek +1 more
openaire +2 more sources

C-Type Lectins in Innate Immunity to Pathogens

Trends in Glycoscience and Glycotechnology, 2004
自然免疫系は感染に対する防御機構の最前線であり、防御機構の始動にとって非常に重要である。侵入した病原体は、樹状細胞 (Dendritic cell: DC) の表面に発現する Toll 様受容体やC型レクチン (CLR) などの病原体認識受容体によって認識される。DCが病原体由来の抗原を捕捉すると、DCには病原体を排除することに特化するような様々な変化が生じる。CLRは病原体の表面や分泌物に存在する糖抗原を特異的に捕捉し、その結果として抗原のプロセシングと提示が行われる。しかし、現在の実験事実はCLRが2つの機能を持つことを示唆している。すなわち、CLRは病原体由来抗原の認識に加え、糖付加を受けた自己抗原の認識機構としても機能しており、恒常性の制御と免疫寛容を誘導するというものである。興味深いことに、
Van Die, Irma, Engering, Anneke, Van Kooyk, Yvette +2 more
openaire +3 more sources

Modulation of Animal Gut Health by Milk Oligosaccharide

Animal Research and One Health, EarlyView.
This review summarizes the composition and structural characteristics of MOs across different mammalian species, and elucidates their roles and mechanisms in maintaining intestinal homeostasis by regulating gut microbiome and enhancing intestinal chemical, physical and immune barriers.
Ningtao Chen +7 more
wiley +1 more source

Identifying Systemic Lupus Erythematosus From Serum Proteomic Profiles Using Machine Learning and Genetic Risk Stratification

Arthritis &Rheumatology, EarlyView.
Objective Proteome‐wide risk models for lupus remain underexplored. We developed classification models to identify lupus from serum proteomic profiles. Methods Patients with lupus and individuals with other autoimmune diseases in the UK Biobank were included.
Mehmet Hocaoǧlu, Jishnu Das, Amr H. Sawalha +2 more
wiley +1 more source

Higher Complement C4 Gene Copy Number Constitutes a Shared Genetic Risk Factor for Giant Cell Arteritis and IgA Vasculitis

Arthritis &Rheumatology, EarlyView.
Objective Low copy number (CN) of complement C4 isoforms and high CN of retroviral HERV‐K elements are known risk factors for many immune‐mediated inflammatory diseases (IMIDs), often showing sex‐biased effects. Here, we assessed whether CN variation within the C4 gene contributes to giant cell arteritis (GCA) and IgA vasculitis (IgAV), two complex ...
Laura Martínez‐Gutiérrez +295 more
wiley +1 more source

A single-pass type I membrane protein, mannose-specific L-type lectin, potentially involved in the adhesion and invasion of Cryptosporidium parvum

Parasite
Cryptosporidium is a globally distributed zoonotic protozoan parasite that can cause severe diarrhea in humans and animals. L-type lectins are carbohydrate-binding proteins involved in multiple pathways in animals and plants, including protein ...
Zhang Xiaotian +9 more
doaj +1 more source

Homocitrullinated Peptides Drive Pro‐Inflammatory T Cell Responses in a Humanized Mouse Model of Rheumatoid Arthritis

Arthritis &Rheumatology, EarlyView.
Objective Anti‐homocitrullinated protein/peptide antibodies are specific to rheumatoid arthritis (RA) and predictive of worse prognosis, suggesting a pathogenic role for autoreactivity to homocitrullinated peptides (HomoCitP). However, T cell responses to HomoCitP remain largely unexplored.
Sofya Ulanova +6 more
wiley +1 more source

Mechanistic insights into the role of C-type lectin receptor/CARD9 signaling in human antifungal immunity

Frontiers in Cellular and Infection Microbiology, 2016
Human CARD9 deficiency is an autosomal recessive primary immunodeficiency disorder caused by biallelic mutations in the gene CARD9, which encodes a signaling protein that is found downstream of many C-type lectin receptors (CLRs).
Rebecca A. Drummond, Michail S. Lionakis
doaj +1 more source

From Interferon Signature to the Clinical Landscape: Type I Interferonopathies

Arthritis &Rheumatology, EarlyView.
Objective TypeI interferonopathies are heterogeneous diseases driven by dysregulated type I interferon (IFN‐I) signaling. Diagnosis is challenging due to clinical/molecular variability and the need for IFN‐I quantification. The aim of this study was to characterize the clinical, immunologic, genetic, molecular profiles of patients with suspected ...
Ismail Yaz +13 more
wiley +1 more source

c-type lectins
c-type lectin
innate immunity

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immunologic diseases

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