Results 111 to 120 of about 93,360 (302)

Evaluation of Kappaphycus striatus Lectin on SARS-CoV-2 Spike Protein-Specific IgG Responses [PDF]

BIO Web of Conferences
The COVID-19 pandemic highlighted the urgent need for novel therapeutics that would balance vaccines and antivirals. Lectins, which are carbohydrate-binding proteins, can interfere with viral glycoproteins and modulate host immune responses.
Maliki Intan Mariana, Misson Mailin, Teoh Peik Lin, Rodrigues Kenneth Francis, Yong Wilson Thau Lym   +4 more
doaj   +1 more source

Albumin‐Bound STING Agonist Reprograms HSPCs to Antitumor Neutrophils Enhancing CD8+ T Cell Immunity

Advanced Science, EarlyView.
This study demonstrates that an albumin‐bound STING agonist (Nano ZSA‐51D) reprograms HSPCs to produce antitumor neutrophils with enhanced MHC I–mediated CD8+ T cell activation, thereby sensitizing tumors to α‐PD1 therapy. These findings highlight a strategy to target early hematopoiesis for shaping neutrophil fate and potentiating cancer immunotherapy.
Jinsong Tao, Hong‐Yi Zhao, Chengyi Li, Hanning Wen, Fang Ke, Qiuxia Li, Miao He, Bo Wen, Zhongwei Liu, Kai Sun, Wei Gao, Duxin Sun   +11 more
wiley   +1 more source

Isolation and Molecular Characterization of Two Lectins from Dwarf Elder (Sambucus ebulus L.) Blossoms Related to the Sam n1 Allergen

Toxins, 2013
Sambucus species contain a number of lectins with and without antiribosomal activity. Here, we show that dwarf elder (Sambucus ebulus L.) blossoms express two D-galactose-binding lectins that were isolated and purified by affinity chromatography and gel ...
Tomas Girbes, Damian Cordoba-Diaz, José E. Basterrechea, Jesús Tejero, Patricia Cabrero, Pilar Jimenez   +5 more
doaj   +1 more source

PEC‐DFM Hybrid‐Sensor Based on Nanoparticle‐Resolved Estimation for Sensitive and Reversible Glucose Monitoring

Advanced Science, EarlyView.
Abstract The accurate detection of glucose in wound exudate is critically important for monitoring chronic wound healing. While photoelectrochemical (PEC) sensors are widely used, they often suffer from material degradation caused by redox reactions during operation. Herein, we introduce a dark‐field microscopy (DFM) setup integrated with a PEC system,
Zihao Zhang, Junzheng Liu, Qinggong Wu, Yuan Zeng, Gang Xiao, Zhao Yue, Zhigang Zang, Shuang Zhao   +7 more
wiley   +1 more source

Bioinformatic Selection of Mannose-Specific Lectins from Allium genus as SARS-CoV-2 Inhibitors Analysing Protein–Protein Interaction

Life
Mannose-specific lectins are carbohydrate-binding proteins known for their antiviral potential. This study uses a bioinformatic approach to investigate the possibility of lectins from Allium sativum (garlic) and Allium ursinum (wild garlic) as inhibitors
Stefan Isaković, Milan Senćanski, Vladimir Perović, Kristina Stevanović, Ivana Prodić   +4 more
doaj   +1 more source

Lectin-like bacteriocins from pseudomonas spp. utilise D-rhamnose containing lipopolysaccharide as a cellular receptor [PDF]

, 2014
Lectin-like bacteriocins consist of tandem monocot mannose-binding domains and display a genus-specific killing activity. Here we show that pyocin L1, a novel member of this family from Pseudomonas aeruginosa, targets susceptible strains of this species ...
A Hviid, A Molinaro, AC Graham, AD Vinion-Dubiel, AHA Parret, AHA Parret, AJ McCoy, Aleksander W. Roszak, AM Abdel-Mawgoud, AW Schuttelkopf, Brian Smith, C Kleanthous, C Manichanh, CL Brown, CL Ng, D Franke, D Walker, Daniel Walker, DI Svergun, E Cascales, E Kurimoto, EJM Van Damme, F Gorrec, F Long, G Gorkiewicz, G Hester, G Kurisu, GN Murshudov, GR Vasta, Guy Tran Van Nhieu, HL Rocchetta, Inokentijs Josts, J Henao-Mejia, J Qin, JAM Fyfe, JB Lyczak, Joel Milner, JS Lam, JU Scher, K Smith, K Zeth, Kai I. Waløen, KC Carroll, KH Caffall, L Holm, L Stewart, Laura C. McCaughey, M Ramm, M Rivera, M Shimokawa, M-F Incardona, MA Jacobs, MB Kozin, ME Spehlmann, MGK Ghequire, MGK Ghequire, MGK Ghequire, MJ Claesson, N Sharon, Nicholas P. Tucker, NR Chandra, Olwyn Byron, P Emsley, PD Adams, PV Konarev, R Grinter, R Grinter, RA Laskowski, Rhys Grinter, Richard J. Cogdell, S Mori, Sharon Kelly, SY Shaw, T Ogawa, Tom Evans, V Ovod, VB Chen, VV Ovod, VV Volkov, WF Vranken, Y Hao, Y Michel-Briand, YA Knirel   +82 more
core   +4 more sources

Sustainable Phosphorylated Cellulose Nanocrystals: A Dual‐Affinity Platform for High‐Efficiency Enrichment of Intact Glycopeptides and Phosphopeptides

Advanced Science, EarlyView.
AAA ABSTRACT Protein glycosylation and phosphorylation are critical post‐translational modifications (PTMs) governing nearly all cellular functions, yet their analysis remains challenging due to reliance on costly and unsustainable enrichment materials.
Jiaying Li, Wuming Fan, Xuyang Yue, Dongdong Wang, Xiangyu Tang, Zhuo Zhang, Yonggui Wang, Yanjun Xie, Mingliang Ye, Hongqiang Qin   +9 more
wiley   +1 more source

lectins

, 2014
Citation: 'lectins' in the IUPAC Compendium of Chemical Terminology, 3rd ed.; International Union of Pure and Applied Chemistry; 2006. Online version 3.0.1, 2019. 10.1351/goldbook.L03495 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms. Requests for commercial usage
openaire   +2 more sources

Multivalent Glycopolymer Design Unlocks Antimicrobial Activity of 2‐Deoxyglucose

Angewandte Chemie, EarlyView.
New approaches to combat antimicrobial‐resistant pathogens are needed. Here, scaffolding a nonmetabolizable sugar (2DG) on a polymer backbone is shown to significantly improve its antimicrobial activity. ABSTRACT With the increasing prevalence of multidrug‐resistant (MDR) pathogens, last‐line therapeutics such as cyclic peptides are insufficient ...
Sungjin Jeon, Xianjin Qin, Marjon Zamani, Ariel L. Furst, Cassandra E. Callmann   +4 more
wiley   +2 more sources

Tumor‐Induced Splenic Remodeling: Mechanisms of Systemic Immunosuppression and Emerging Therapeutic Opportunities

Advanced Science, EarlyView.
ABSTRACT Despite the transformative impact of cancer immunotherapies such as immune checkpoint blockade, durable clinical responses remain limited. Increasing evidence indicates that antitumor immunity is governed not only by the tumor microenvironment, but also by systemic immune regulation mediated by peripheral immune organs. Among these, the spleen
Yuehua Liu, Xiaoqian Nie, Xiaofei Gao
wiley   +1 more source