Results 91 to 100 of about 4,950,651 (314)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Free form lens and heat sink design for LED illumination

open access: yes, 2011
[[abstract]]The aim of this thesis is to analize the light field radiated from the LED collimator based on the free form secondary optics. It also discusses the thermal distribution cased by different type of heat sink design.
Chen-Bo Yan
core  

Customer-led conceptual design system [PDF]

open access: yes, 2009
This research work is aimed at carrying out a feasibility study for the design of a Customer-Led Design (CLD) system that will allow individuals or users with little or no technical know-how of engineering design but with an idea of what they want to ...
Adeoye, Adeyinka O. Moses
core  

A further examination of the export-led growth hypothesis [PDF]

open access: yes
This paper challenges the common view that exports generally contribute more to GDP growth than a pure change in export volume, as the export-led growth hypothesis predicts. Applying panel cointegration techniques to a production function with non-export
Dreger, Christian, Herzer, Dierk
core   +4 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Simulation And Analysis Of Spectrum And Flux Of LED

open access: yes, 2012
[[abstract]]This thesis presents a compact test system to measure the spectrum and flux of unknown LED. Once we get these two parameters, we can reconstruct the LED model by using the optics simulation software TracePro to interactively verify the ...
Chen, Po-Chang
core  

Household survey to evaluate the Zambia-led Prevention Initiative: Baseline report

open access: yes, 2012
With an estimated HIV prevalence of 14.3 percent among men and women age 15–49, Zambia is one of the sub-Saharan African countries most affected by the HIV and AIDS pandemic.
Zambia-led Prevention Initiative
core   +1 more source

Assessing the effects of green innovation, renewable energy, and environmental policy stringency on ecological and material footprints in G7 economies

open access: yesDiscover Environment
Ecological pressure is a multidimensional measure that includes factors such as water and soil pollution, air quality, and raw material consumption. It is therefore important to consider the determinants of ecological stress using many indicators to ...
Emna Omri, Chiraz Feki, Nouri Chtourou
doaj   +1 more source

Collapse of Silicon Valley Bank and USDC Depegging: A Machine Learning Experiment

open access: yesFinTech
The collapse of Silicon Valley Bank (SVB) on 11 March 2023, and the subsequent depegging of the USDC stablecoin highlighted vulnerabilities in the interconnected financial ecosystem. While prior research has explored the systemic risks of stablecoins and
Papa Ousseynou Diop   +2 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

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