Results 111 to 120 of about 6,113,621 (257)

Ladefaciliteter - Kommunerne baner vejen for præcise data

Geoforum Perspektiv
Kommunerne ville skabe en ny normal for ladestanderdata i 2022.  Der var brug for: • Transparens i et nyt marked, som var på vej mod kritisk infrastruktur • Gratis adgang – uden abonnement og apps • Ladestandere til biler, men også til ...
Sofie Kofoed Led
doaj  

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Export-led growth hypothesis: Evidence for Chile [PDF]

This study examines the export-led growth hypothesis using annual time series data from Chile. It addresses the problem of specification bias under which previous studies have suffered and focuses on the impact of manufactured and primary exports on the ...
Boriss Siliverstovs, Dierk Herzer
core  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Programas de mediación en Catalunya para la resolución no penal de conflictos juveniles

Psicologia Revista
A extensão dos anos de educação obrigatória é um feito social bastante apreciado nos países mais desenvolvidos. Na Espanha, por exemplo, a nova Lei Geral de Educação Espanhola (LOGSE - 1990) ampliou a idade escolar até os 16 anos.
Pere Led Capaz
doaj  

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

FLIARA: D3.2 - Inventory of female-led innovations

The FLIARA project aims to create an inclusive and empowering innovation ecosystem for rural women, ensuring they are recognised, supported, and celebrated in their accomplishments.
Weir, Louise, McGuinness, Niamh, Ahl, Helene, Roos, Annie, Nolan, Niamh, Sivini, Silvia, Farrell, Maura, Ahl, Helene,, Roos, Annie,   +8 more
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Recommended long COVID outcome measures and their implications for clinical trial design, with a focus on post-exertional malaise

EBioMedicine
Summary: Long COVID has created a worldwide public health crisis and has no approved treatments or validated biomarkers. We summarize the current challenges and considerations of outcome selection in Long COVID trials, along with recommendations for ...
Letícia Soares, Hannah Davis, Ezra Spier, Tiffany Walker, Todd Davenport, David Putrino, Michael Peluso, Julia Moore Vogel   +7 more
doaj   +1 more source