Results 81 to 90 of about 313,949 (308)

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Three Metaphors toward a Conception of Moral Change

open access: yesNordic Wittgenstein Review, 2018
Contemporary moral philosophy is split between an inherently a-historical moral philosophy/theory on the one hand and a growing interest in moral history and the historicity of morality on the other.
Nora Hämäläinen
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

The New Left. 1968 and Post Scriptum

open access: yesRevista Mexicana de Ciencias Políticas y Sociales, 2018
INTRODUCTORY NOTE The author, a well know theorist and activist of the civil rights movement and the movement against the Vietnam War, published the first part of this article from his own intervention and experience in 1968.
Michael Walzer
doaj   +1 more source

Objective realism and freedom of choice in relativistic quantum field theory

open access: yes, 2016
Traditional Bell's argument shows that freedom of choice is inconsistent with quantum realism if lack of signaling and sufficiently fast choices and readouts are assumed.
Bednorz, Adam
core   +1 more source

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

open access: yesFEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang   +5 more
wiley   +1 more source

O historiador e o teórico: a historiografia de Hobbes na teoria das relações internacionais The historian and the theoretician: Hobbes' historiography in the theory of international relations

open access: yesContexto Internacional, 2003
Uma dificuldade crucial no estudo das relações internacionais é unir investigação teórica com investigação histórica. O objetivo deste artigo é analisar como Hobbes enfrentou este problema, bem como em que medida a solução que apresentou influenciou a ...
Soraya Nour, Claus Zittel
doaj   +1 more source

Experimenter's Freedom in Bell's Theorem and Quantum Cryptography

open access: yes, 2005
Bell's theorem states that no local realistic explanation of quantum mechanical predictions is possible, in which the experimenter has a freedom to choose between different measurement settings.
I. Csiszár   +6 more
core   +1 more source

The role and implications of mammalian cellular circadian entrainment

open access: yesFEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

open access: yesFEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang   +8 more
wiley   +1 more source

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