Results 101 to 110 of about 56,322 (293)
G3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K‐AKT‐mTOR Signal Axis
Advanced Science, EarlyView.Schematic illustrating the impact of G3BP1 succinylation at K413 on cardiac function. In the healthy human heart, G3BP1 succinylation maintains homeostatic mTOR signaling. In patients with dilated cardiomyopathy (DCM) and heart failure (HF), G3BP1 de‐succinylation induces RagA expression and disrupts the binding of the TSC1/2 complex, leading to the ...
Yuan Zhang +9 more
wiley +1 more source
Legal Drafting: Curing Unexpressive Language [PDF]
, 1971 By using many examples of confusing statutes, the author expresses the need for more careful drafting in legal writing. Grammatical errors and esoteric legalese render confusing laws.
Kirk, Maurice B.
core
Advanced Science, EarlyView.The hyperactivation of PI3K/AKT signaling in PTEN wild‐type triple‐negative breast cancer represents a clinical paradox. We delineate a novel post‐translational regulatory axis wherein the oncogene TSPYL5 competitively antagonizes the deubiquitinase USP10.
Jiaying Shi +8 more
wiley +1 more source
How to Create Contract Drafting Exercises [PDF]
, 2009 This article focuses on different methods of teaching contract drafting to first-year students in a legal writing course. Four professors offer their own approaches to creating practical exercises; these exercises are designed to aid students in ...
Penland, Lisa +3 more
core +1 more source
Organoid Brain‐Machine‐Interface Devices for Central Nervous System Repair
Advanced Science, EarlyView.We envision organoid brain‐machine‐interface (Organoid‐BMI) devices as new biohybrid bidirectional communication pathways to connect the human CNS and the external world for personalized CNS repair and regeneration. ABSTRACT Central nervous system (CNS) repair and regeneration suffer from tremendous clinical challenges due to current limitations in ...
Yantao Xing +10 more
wiley +1 more source
Vyšší moc, hardship aneb Smluvní doložky v mezinárodní praxi
Časopis pro Právní Vědu a Praxi, 2015 Force majeure and hardship – two legal terms connected with drafting contracts (with or without cross-border element); two concepts having some common features; however, two concepts which are different in their preconditions, and in their legal ...
Naděžda Rozehnalová
doaj
A Piezo‐Mimetic Ionic Hydrogel Harnessing Joint Motion for Cartilage Repair
Advanced Science, EarlyView.A piezo‐mimetic ionic hydrogel converts mechanical deformation into bioactive ionic currents via stress‐induced asymmetric ion migration. Coupled with sustained Mg2+ release, this mechano‐electrochemical platform bridges mechanical loading and cellular signaling, enabling load‐adaptive stimulation and enhanced cartilage regeneration. ABSTRACT Articular
Chenyuan Gao +14 more
wiley +1 more source
The NAI Suite – Drafting and Reasoning over Legal Texts
, 2019 A prototype for automated reasoning over legal texts, called NAI, is presented. As an input, NAI accepts formalized logical representations of such legal texts that can be created and curated using an integrated annotation interface. The prototype supports automated reasoning over the given text representation and multiple quality assurance procedures.
Tomer Libal, Alexander Steen
openaire +3 more sources
Advanced Science, EarlyView.PLD3 activates the lysosomal‐AKT‐NF‐κB axis to drive cellular senescence in macrophages, establishing an immunosuppressive TME by limiting the infiltration of cytotoxic T, NK, and NKT cells, which confers resistance to anti‐PD‐1 therapy. Abrine inhibits PLD3 expression, restoring antitumor immunity and synergizing with anti‐PD‐1 treatment.
Xingtu Qin +11 more
wiley +1 more source
Femtosecond‐Laser‐Induced Physical Unclonable Random Maze Structure for Storage‐Free Encryption
Advanced Science, EarlyView.Femtosecond‐laser‐induced gold random maze structures serve as multimodal physical unclonable functions for storage‐free encryption. Their stochastic optical, electrical, and Raman responses are generated by plasmon‐assisted Marangoni formation and converted into AES‐compatible keys without permanent secret‐key storage, offering a portable route toward
Shiru Jiang +6 more
wiley +1 more source