Results 101 to 110 of about 2,984,612 (283)
Advanced Science, EarlyView.Endothelin receptor type A (EDNRA) and the Hippo/YAP pathway form a self‐reinforcing loop that sustains triple‐negative breast cancer. EDNRA activates YAP through Gαq/11–Rho/ROCK–LATS signaling, while YAP/TEAD4 reciprocally drives EDNRA transcription.
Zehao Hong +10 more
wiley +1 more source
Advanced Science, EarlyView.HOXC11 drives colorectal cancer progression by transcriptionally activating CAMK2A, which triggers NF‐κB–dependent CXCL5 upregulation. CXCL5–CXCR2 signaling further reinforces HOXC11 expression through the ERK1/2–SP1 axis, forming a prometastatic positive feedback loop that is effectively disrupted by combined CAMK2A and CXCR2 inhibition.
Qingyang Sun +12 more
wiley +1 more source
Legal Positivism as an Idea About Morality
, 2011 I ask what a proper critical target for \u27legal positivism\u27 might be. I argue that utilitarian moral theory, and more generally fully directive moral theories, are unacknowledged motivations for legal positivism.
Stone, Martin J.
core
Legal Positivism and Legal Adjudication
, 2004 En este artículo se trata el problema de cómo se refleja la tesis iuspositivista de la identificación del Derecho en la aplicación del Derecho. Como corolario de la tesis positivista de las fuentes del Derecho, la tesis de la identificación del Derecho ...
Moreso Mateos, Josep Joan +1 more
core +1 more source
Neuromorphic Devices and Computing for Sensing, Memory, and Control
Advanced Science, EarlyView.This review introduces neuromorphic devices made from diverse materials. These devices mimic neuronal functions and architectures and, when integrated with artificial or biological computing, can form closed loops with neurons for pressure, optical, acoustic, and biochemical sensing and modulation.
Zhengguang Zhu +2 more
wiley +1 more source
Shuman: Legal Positivism: Its Scope and Limitations [PDF]
, 1963 A Review of Shuman: Legal Positivism: Its Scope and Limitations .
Bodenheimer, Edgar
core
Advanced Science, EarlyView.USP30 accumulation in diabetic renal tubular epithelial cells deubiquitinates PEX5, suppresses pexophagy, and drives dysfunctional peroxisome accumulation and tubular injury. USP30 depletion restores PEX5 ubiquitination and pexophagy, improves peroxisomal function, and alleviates tubular damage, highlighting USP30 as a therapeutic target in diabetic ...
Jia Li +10 more
wiley +1 more source
Nowe wyzwanie dla pozytywizmu prawniczego [PDF]
Archiwum Filozofii Prawa i Filozofii Społecznej, 2014 In his lecture, delivered at the Department of the Philosophy of Law of the Autonomous University of Madrid on 29 October 1979, H.L.A. Hart directly responds to Ronald Dworkin’s attack on Legal Positivism, launched in Taking Rights Seriously.
Herbert L.A. Hart
doaj
On the incoherence of legal positivism [PDF]
, 2000 Legal positivism is an incoherent intellectual enterprise. It sets itself an explanatory task which it makes itself incapable of carrying through. In the result it offers its students purported and invalid derivations of ought from is.
Finnis, John, Finnis, J, Finnis, John M.
core
Advanced Science, EarlyView.A one‐pot, aqueous, and scalable method for synthesizing chiral lanthanide supramolecular emitters using terbium and threonine is reported. The aqueous solution of these chiral emitters displays the following features: (i) 100 % transparency, (ii) tunable luminescence and CPL, and (iii) a pH feedback loop that controls the “on‐off” states of ...
P. M. Ajay Sekhar +5 more
wiley +1 more source