Results 81 to 90 of about 90,256 (303)

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu   +21 more
wiley   +1 more source

A LÓGICA DEDUTIVA SOB A ÓTICA DA INTERPRETAÇÃO JURÍDICA E DA TEORIA DA DECISÃO

open access: yesColloquium Humanarum, 2011
This paper discusses the application of deductive logical reasoning in the interpretation and legal decision, focusing on legal positivism and its base of constitution in a democratic state. The study aims to examine the contours of legal positivism from
Ana Augusta Rodrigues Westin Ebaid
doaj   +1 more source

Avortement, éthique sociale et positivisme juridique [PDF]

open access: yes, 1991
Cet article a pour objectif de défendre un point de vue positiviste du droit de certaines erreurs et confusions commises à son égard. L'auteur se sert d'un récent article de G. Legault (« La parole du philosophe éthicien est-elle crédible?
Blais, François
core   +1 more source

Spatial and Volumetric Characteristics of Glioblastoma: Associations With Clinical Presentation and Survival

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective We aim to comprehensively analyze how regional tumor and edema characteristics are associated with clinical presentations and survival outcomes in a large cohort of glioblastoma patients. Methods Patients with IDH‐wildtype glioblastoma who received brain MRI from 2010 to 2023 were included.
Daniel J. Zhou   +15 more
wiley   +1 more source

NORMATIVITAS KEILMUAN HUKUM DALAM PERSPEKTIF ALIRAN PEMIKIRAN NEO-KANTIAN

open access: yesMasalah-Masalah Hukum, 2015
Scientific normativity of law conceived as a character inherent in legal science as a sui generis. Jurisprudence basically study the law, something that initially emerged from the dogmatic belief in philosophy.
FX. Adji Samekto
doaj   +1 more source

Three Positivisms [PDF]

open access: yes, 1998
In this article, I accept and hope to expand upon the conventional consensus view that The Path of the Law is a brief for an Americanized version of Austinian legal positivism and for the separation of law and morality that is at its core.
West, Robin
core   +1 more source

Pharmacokinetics, Pharmacodynamics, and Safety of Subcutaneous Belimumab in Pediatric Patients With Systemic Lupus Erythematosus: A Multicenter, Open‐Label Trial

open access: yesArthritis Care &Research, EarlyView.
Objective This study aimed to characterize the pharmacokinetics, pharmacodynamics, safety, and exploratory efficacy of subcutaneous belimumab in pediatric patients with active systemic lupus erythematosus (SLE) receiving standard therapy. Methods This single‐arm, multicenter, open‐label trial (GSK study 200908; ClinicalTrials.gov identifier ...
Hermine I. Brunner   +14 more
wiley   +1 more source

Validation of the Pediatric Arthritis Ultrasound Scoring System for the Elbow, Wrist, and Finger Joints in Children With Juvenile Idiopathic Arthritis

open access: yesArthritis Care &Research, EarlyView.
Objective We aimed to validate the Pediatric Arthritis Ultrasound Scoring System (PAUSS) for upper extremity joints in children with juvenile idiopathic arthritis (JIA). Methods Children with JIA were evaluated for elbow, wrist, or finger arthritis by clinical examination (CE) and musculoskeletal ultrasound (MSUS) with images scored according to the ...
Patricia Vega‐Fernandez   +12 more
wiley   +1 more source

Normativity of Scientific Law in the Perspective of Neo-Kantian Schools of Thought

open access: yesHasanuddin Law Review, 2017
Scientific normativity of law conceived as a character inherent in legal science as a sui generis. Jurisprudence basically studies the law, something that initially emerged from the dogmatic belief in philosophy.
FX. Adji Samekto, Ani Purwanti
doaj   +1 more source

An Interactionist View on the Relation between Law and Morality [PDF]

open access: yes, 2003
Introduction The claim of this book is that many issues may be put into a new light if we analyse them with explicit attention to the role of ideals. The relation between law and morality is one of these themes; indeed, my claim is that we will not
Burg, W. (Wibren) van der
core  

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