Presence of Legionellaceae in warm water supplies and typing of strains by polymerase chain reaction [PDF]
Outbreaks of Legionnaire's disease present a public health challenge especially because fatal outcomes still remain frequent. The aim of this study was to describe the abundance and epidemiology of Legionellaceae in the human-made environment.
Brengelmann, F. +3 more
core +1 more source
Cytosolic recognition of flagellin by mouse macrophages restricts Legionella pneumophila infection. [PDF]
To restrict infection by Legionella pneumophila, mouse macrophages require Naip5, a member of the nucleotide-binding oligomerization domain leucine-rich repeat family of pattern recognition receptors, which detect cytoplasmic microbial products.
Byrne, Brenda G +6 more
core +2 more sources
Antimicrobial peptides (AMPs) are promising candidates for next‐generation antibiotics, acting through mechanisms such as membrane disruption and intracellular targeting. This review examines how variations in bacterial membrane composition critically influence AMP activity.
Paolo Rossetti +5 more
wiley +1 more source
Molecular detection of Legionella: moving on from mip
The detection of Legionella pneumophila in environmental and clinical samples is frequently performed by PCR amplification of the mip and/or 16S rRNA genes. Combined with DNA sequencing, these two genetic loci can be used to distinguish different species
Stacey FY Yong +7 more
doaj +1 more source
Legionella pneumophila-Derived Outer Membrane Vesicles Promote Bacterial Replication in Macrophages. [PDF]
The formation and release of outer membrane vesicles (OMVs) is a phenomenon of Gram-negative bacteria. This includes Legionella pneumophila (L. pneumophila), a causative agent of severe pneumonia. Upon its transmission into the lung, L.
Anna Lena Jung +5 more
doaj +1 more source
Glycine-vancomycin-polymyxin-cycloheximide agar (GVPC) is a recommended medium for the detection of Legionella spp. in water samples. However, its quality could be improved in terms of recovery of Legionella spp. and selectivity properties. Modifications
Pablo Casino +9 more
doaj +1 more source
Cas9 beyond CRISPR – SUMOylation, effector‐like potential and pathogenic adaptation
This Viewpoint explores the possibility that Cas9, beyond its canonical role in CRISPR immunity, may act as a host‐modulating effector during infection by Cas9‐encoding bacteria. Such a nucleomodulin‐like function could be influenced by eukaryotic post‐translational modifications, particularly SUMOylation, with potential implications for host–pathogen ...
Umut Sahin
wiley +1 more source
Miocardite fulminante a Legionella pneumophila – a propósito dum caso clínico
Resumo: A miocardite é uma doença inflamatória do miocárdio. Pode‐se apresentar de forma subtil ou fulminante.Apresenta‐se o caso duma mulher de 39 anos com choque cardiogénico no contexto de miocardite fulminante, com necessidade de colocação de ...
Ana Filipa Damásio +6 more
doaj +1 more source
Characterization of avirulent mutant Legionella pneumophila that survive but do not multiply within human monocytes. [PDF]
Legionella pneumophila, the causative agent of Legionnaires' disease, is a Gram-negative bacterium and a facultative intracellular parasite that multiplies in human monocytes and alveolar macrophages. In this paper, mutants of L.
Horwitz, MA
core
Occupational risk for Legionella infection among dental healthcare workers: meta-analysis in occupational epidemiology [PDF]
Objective The occupational risk for Legionella infection among dental healthcare workers (DHCWs) is conjectured because of the risk of routine inhalation of potentially contaminated aerosols produced by the dental instruments.
Petti, Stefano, Vitali, Matteo
core +1 more source

