Results 81 to 90 of about 52,688 (260)

Aptamer Engineering: Strategies for Discovering Functional Nucleic Acids for Next‐Generation Diagnostics and Biosensing

Advanced Science, Volume 13, Issue 2, 9 January 2026.
The advent of aptamers has highlighted their potential as alternatives to antibodies, overcoming limitations of structural instability and production cost. However, conventional approaches such as SELEX remain slow and labor‐intensive. This review examines recent advances in aptamer engineering, emphasizing in vitro and AI‐driven in silico strategies ...
John V. L. Nguyen, Ahlem Meziadi, Cyrill Brunner, Maureen McKeague, Lidija Malic, Maryam Tabrizian   +5 more
wiley   +1 more source

Legionella affects biofilm structural response to detachment upon shear stress increase

Biofilm
Poor hydraulic management at water systems is associated with an increased risk of Legionnaires' disease caused by Legionella. Stagnation periods, followed by sudden water flow, can promote biofilm detachment and the release of Legionella into the bulk ...
Ana Rosa Silva, C. William Keevil, Ana Pereira   +2 more
doaj   +1 more source

Advances and challenges in point‐of‐care testing for pathogenic bacteria in battlefield injuries

Interdisciplinary Medicine, Volume 4, Issue 1, January 2026.
This review explores trauma‐associated bacterial species, summarizes these biosensor advancements, addresses fabrication challenges, outlines future directions, and aims to guide POCT biosensor development for combat/trauma care bacterial detection.
Junjie Fan, Shuai Liu, Dan Luo, Hengjun Zhang, Xianling Dai, Hanqing Xu, Man Shen, Yingchun Huang, Yupeng Long, Ming Chen, Qiaofeng Li, Jing Bao   +11 more
wiley   +1 more source

Polar delivery of Legionella type IV secretion system substrates is essential for virulence [PDF]

, 2017
A recurrent emerging theme is the targeting of proteins to subcellular microdomains within bacterial cells, particularly to the poles. In most cases, it has been assumed that this localization is critical to the protein’s function. Legionella pneumophila
Chang, Yi-Wei, Ghosal, Debnath, Jensen, Grant J., Jeong, Kwangcheol C., Vogel, Joseph P.   +4 more
core   +1 more source

A plasmid in Legionella pneumophila [PDF]

Infection and Immunity, 1980
Sixteen strains from the six serogroups of Legionella pneumophila were examined for the presence of extrachromosomal genetic elements by a modified cleared lysate procedure, dye-buoyant centrifugation, and agarose gel electrophoresis. Two strains, Atlanta-1 and Atlanta-2 from serogroup II, each contained a plasmid of cryptic function with a molecular ...
G B, Knudson, P, Mikesell
openaire   +2 more sources

Severe Necrotizing Community‐Acquired Pneumonia and Bilateral Empyema in an Immunocompetent Patient due to Fusobacterium necrophorum

Case Reports in Pulmonology, Volume 2026, Issue 1, 2026.
Necrotizing pneumonia and empyema caused by Fusobacterium necrophorum are uncommon. The classical presentation of Lemierre′s syndrome, characterized by pharyngotonsillitis and internal jugular vein thrombosis, is not always observed, and incomplete and atypical variants can cause diagnostic uncertainty and delay in treatment.
Deborah Shefa, Aryan Shiari, Marina Antic, Buddhi P. Hatharaliyadda, Juan Vera Gomez, David Ladin, Igor Dumic, Tun-Chieh Chen   +7 more
wiley   +1 more source

Non‐pneumophila Legionella species pneumonia with orange‐coloured sputum

Respirology Case Reports, 2021
We herein report an immunocompromised patient familiar with gardening admitted to our hospital suffering from severe pneumonia caused by Legionella longbeachae.
Maki Asami‐Noyama, Misa Harada, Kaori Murakawa, Junki Suizu, Keita Murakawa, Ayumi Chikumoto, Kazuki Hamada, Yoriyuki Murata, Keiji Oishi, Yoshikazu Yamaji, Nobutaka Edakuni, Tsunahiko Hirano, Tomoyuki Kakugawa, Kazuto Matsunaga   +13 more
doaj   +1 more source

Molecular diversity and high virulence of Legionella pneumophila strains isolated from biofilms developed within a warm spring of a thermal spa. [PDF]

, 2013
International audienceABSTRACT: BACKGROUND: Several cases of legionellosis have been diagnosed in the same French thermal spa in 1986, 1994 and 1997. L.
Atlan, Danièle, Chaabna, Zineddine, Fontvieille, Dominique, Forey, Françoise, Gilbert, Christophe, Jarraud, Sophie, Reyrolle, Monique   +6 more
core   +4 more sources

Serospecific antigens of Legionella pneumophila [PDF]

Journal of Bacteriology, 1986
Serospecific antigens isolated by EDTA extraction from four serogroups of Legionella pneumophila were analyzed for their chemical composition, molecular heterogeneity by sodium dodecyl sulfate-polyacrylamide gel electrophoresis, and immunological properties. The antigens were shown to be lipopolysaccharides and to differ from the lipopolysaccharides of
S, Otten, S, Iyer, W, Johnson, R, Montgomery   +3 more
openaire   +2 more sources

Case Report: Omadacycline in the Treatment of Community‐Acquired Pneumonia in a Child With Multiple Antimicrobial Allergies

Clinical Case Reports, Volume 13, Issue 12, December 2025.
ABSTRACT Omadacycline, a novel once‐daily aminomethylcycline antibiotic agent, demonstrates efficacy against prevalent pathogens responsible for community‐acquired pneumonia (CAP) in adults. However, the safety and efficacy of omadacycline in younger children have not yet been established.
Ziqi Xu, Wen Pan, Hui Lei, Chen Dong, Biao Zou, Sainan Shu, Wenting Zhang   +6 more
wiley   +1 more source