Results 31 to 40 of about 66,420 (242)

Fluorescence in situ Hybridization (FISH) in the Microbiological Diagnostic of Deep Sternal Wound Infection (DSWI)

Infection and Drug Resistance, 2021
Nick Spindler,1 Annette Moter,2,3 Alexandra Wiessner,2,3 Tanja Gradistanac,4 Michael Borger,5 Arne C Rodloff,6 Stefan Langer,1 Judith Kikhney2,3 1Department of Orthopedic Surgery, Traumatology and Plastic Surgery, University Hospital Leipzig, Leipzig ...
Spindler N, Moter A, Wiessner A, Gradistanac T, Borger M, Rodloff AC, Langer S, Kikhney J   +7 more
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Common Signatures of Altered Gene Regulation and Invasiveness of Different Breast Cancer Cell Lines after Matrix Interface Crossing

Advanced Healthcare Materials, EarlyView.
Interface transmigration reprograms triple‐negative breast cancer cells, triggering a shared switch toward more aggressive and invasive phenotypes. Using a collagen I interface model, this study identifies shared transcriptional changes involving proliferation, chromatin remodeling, and DNA repair pathways.
Cornelia Clemens, Hannah Trampert, Nataliia Kotsiuba, Tilo Pompe   +3 more
wiley   +1 more source

RIG‐I Mediated Neuron‐Specific IFN Type 1 Signaling in FUS‐ALS Induces Neurodegeneration and Offers New Biomarker‐Driven Individualized Treatment Options for (FUS‐)ALS

Advanced Science, EarlyView.
Using iPSC‐derived motoneurons and postmortem tissue from FUS‐ALS patients, it is demonstrated that increased mitochondrial transcription leads to elevated cytosolic double‐stranded RNA (dsRNA) levels. This aberrant accumulation activates a RIG‐I–dependent innate immune response leading to neurodegeneration, which is amenable for FDA‐ and EMA‐approved ...
Marcel Naumann, Theresa M. Wierschin, Stefanie Kretschmer, Banaja P. Dash, Aaron Held, Andrea Salzinger, Kevin Peikert, Anže Karlek, Hannes Glaß, Dajana Großmann, René Günther, Susanne Petri, Annekathrin Rödiger, David Brenner, Francisco Pan‐Montojo, Eleonora Aronica, Markus Kipp, Vitaly Zimyanin, Jared Sterneckert, Torsten Grehl, Noah D. Seebacher, Tobias M. Böckers, Alberto Catanese, Brian J. Wainger, Patrick Oeckl, Min Ae Lee‐Kirsch, Andreas Hermann   +26 more
wiley   +1 more source

Overcoming Barriers in Nurse-Pharmacist Collaborations on Wards – Qualitative Expert Interviews with Nurses and Pharmacists

Journal of Multidisciplinary Healthcare, 2023
Ines Wakob,1,2 Susanne Schiek,1,2 Thilo Bertsche1,2 1Clinical Pharmacy, Institute of Pharmacy, Medical Faculty, Leipzig University, Leipzig, Germany; 2Drug Safety Center, Faculty of Medicine, University Hospital of Leipzig and Leipzig University, Leipzig,
Wakob I, Schiek S, Bertsche T
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Coupled Above‐ and Belowground Ecosystem Stability Worldwide

Advanced Science, EarlyView.
Are the worlds above and below our feet in sync? This global exploration reveals an entangled fate between above‐ and belowground ecosystem stability. It identifies arid regions as hotspots for this coupling and highlights temperature stability as a vital safeguard for maintaining ecosystem balance across our warming planet.
Zexin Meng, Huiwen Li, Yiping Wu, Peter B. Reich, Nico Eisenhauer, Diego Abalos, Daniel Revillini, Shuguang Liu, Wende Yan, Ji Chen, Alexey Voinov, Zhifeng Yang, Ying‐Ping Wang, Fubo Zhao, Linjing Qiu, Jingfeng Xiao, Shantao An, Guopeng Liang, Manuel Delgado‐Baquerizo   +18 more
wiley   +1 more source

La Escuela de Leipzig o la justificación epistemológica del conservadurismo

Ideas y Valores, 2023
Poco se ha escrito sobre uno de los intentos más radicales de fundamentación del conservadurismo; como son las obras de Hans Freyer, Arnold Gehlen y Helmut Schelsky  (principales representantes de la Escuela de Leipzig).
Francisco Mujica Coopman, Juan Chavez Albarran   +1 more
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Scale‐up of Streptomyces species cultivations based on the morphological response to the energy dissipation rate

AIChE Journal, EarlyView.
Abstract Filamentous microorganisms exhibit complex morphologies that influence product formation and are affected by various bioprocess parameters. Consistent morphology is therefore essential for comparable results during scale‐up. This study investigates the scale‐up of Streptomyces species (Streptomyces spp.) cultivations from shake flasks to ...
Gesa Brauneck, Anton Brass, Artiom Boreiko, Marvin Ueßeler, Marcel Mann, Johannes Pastoors, Valentin Steier, Philipp Eibl, Christian Witz, Dorothea M. Schütterle, Ivan Schlembach, Miriam A. Rosenbaum, Jorgen Magnus   +12 more
wiley   +1 more source

Relative Exchangeable Copper Confirms Wilson Disease and Supports Reclassification of the ATP7B p.Met665Ile Variant With Conflicting Pathogenicity Evidence

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Wilson disease (WD) is an autosomal recessive disorder of copper metabolism caused by ATP7B mutations. Diagnosis is usually straightforward in symptomatic patients, but can be challenging in children and adolescents with mild liver disease, borderline urinary copper excretion, or inconclusive genetic findings.
Emanuele Nicastro, Caterina Zuccoli, Roberto Marozzi, Antonino Barletta, Lisa Licini, Paola Tebaldi, Valeria Casotti, Mariangela Stinco, Lidia Pezzani, Maria Iascone, Lorenzo D'Antiga   +10 more
wiley   +1 more source

Auditory Hyperresponsivity in Chronic Back Pain: A Randomized Controlled Trial of Pain Reprocessing Therapy

Annals of Neurology, EarlyView.
Objective Heightened sensitivity to noxious stimulation is a hallmark of chronic pain. Emerging evidence suggests heightened unpleasantness to non‐noxious (eg, auditory) aversive stimulation also characterizes chronic pain, but its magnitude, neural mechanisms, and treatment modifiability remain unknown.
Alina E. C. Panzel, Christian Büchel, Andrew Leroux, Tor D. Wager, Yoni K. Ashar   +4 more
wiley   +1 more source

Non-Right Handedness is Associated with More Time Awake After Sleep Onset and Higher Daytime Sleepiness Than Right Handedness: Objective (Actigraphic) and Subjective Data from a Large Community Sample

Nature and Science of Sleep, 2022
Hilde Taubert,1 Matthias L Schroeter,2– 4 Christian Sander,1,4,* Michael Kluge1,* 1Department of Psychiatry and Psychotherapy, University of Leipzig, Leipzig, Germany; 2Department of Neurology, Max Planck Institute for Human Cognitive and Brain ...
Taubert H, Schroeter ML, Sander C, Kluge M   +3 more
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