Results 1 to 10 of about 6,545 (134)

Dicentrine, an Aporphine Alkaloid From Ocotea langsdorffii, Induces Mitochondrial Dysfunction and Oxidative Stress in Leishmania (L.) infantum. [PDF]

Chem Biodivers
Dicentrine, an aporphine alkaloid, exhibits potent in vitro antileishmanial activity against Leishmania species with high selectivity and low macrophage cytotoxicity. Mechanistic studies reveal that the compound triggers parasite death possibly by inducing mitochondrial membrane disruption and oxidative stress.
de Freitas CS, da Silva EOS, Tristão DC, Antar GM, Lage DP, Abrão DM, Antinarelli LMR, Coimbra ES, Lago JHG, Coelho EAF.   +9 more
europepmc   +2 more sources

Canine Leishmaniasis in Rio de Janeiro, Brazil (2000-2015): Taxonomic Characterisation of Etiological Agents and Geospatial Case Analysis. [PDF]

Zoonoses Public Health
ABSTRACT Introduction Canine Leishmaniasis is a vector‐borne zoonotic disease caused by several species of protozoa of the genus Leishmania. In the state of Rio de Janeiro (RJ), Leishmania braziliensis is the most prevalent species causing tegumentary leishmaniasis (TL) and Leishmania infantum is the main causative agent of visceral leishmaniasis (VL).
Miranda LFC, Coelho LFDR, Xavier SCDC, Junior AAVM, Albuquerque RN, da Silva AF, Marcelino AP, Santos FN, Pereira SA, Menezes RC, Schubach AO.   +10 more
europepmc   +2 more sources

Identification of a Benzenesulfonylpiperazine Derivative With In Vivo Efficacy Against Visceral Leishmaniasis. [PDF]

Chem Biol Drug Des
This work highlights the satisfactory pharmacokinetic profile of two benzenesulfonylpiperazine lead candidates, followed by in vivo assessment in a murine model of visceral leishmaniasis. This assessment identified compound 2 as moderately active at a lower dose, but its efficacy increased at higher doses, though with concerns regarding safety.
Jacques Dit Lapierre TJW, Gabriela Faleiro de Moura Lodi Cruz M, Freitas de Lima Hercos G, Chelucci RC, Michelan-Duarte S, Barbosa G, Costa AR, Chávez-Fumagalli MA, Derksen Macruz P, Jorge Pilau E, Ferreira LLG, Andricopulo AD, Maria Fonseca Murta S, de Oliveira Rezende Júnior C.   +13 more
europepmc   +2 more sources

The immunobiology of Leishmania braziliensis infection

Frontiers in Immunology, 2012
Leishmaniases are a group of diseases caused by protozoa of the genus Leishmania that affect millions of people worldwide. These diseases are caused by distinct Leishmania species, of which L.
Camila I de Oliveira, Claudia Brodskyn
exaly   +3 more sources

The Role of Nitric Oxide and Reactive Oxygen Species in the Killing of Leishmania braziliensis by Monocytes from Patients with Cutaneous Leishmaniasis. [PDF]

PLoS ONE, 2016
Human cutaneous leishmaniasis (CL) caused by Leishmania braziliensis, presents an exaggerated Th1 response that is associated with ulcer development. Macrophages are the primary cells infected by Leishmania parasites and both reactive oxygen species (ROS)
Pedro Paulo Carneiro, Jacilara Conceição, Michael Macedo, Viviane Magalhães, Edgar M Carvalho, Olivia Bacellar   +5 more
doaj   +1 more source

Exposure to Leishmania braziliensis triggers neutrophil activation and apoptosis. [PDF]

PLoS Neglected Tropical Diseases, 2015
BACKGROUND: Neutrophils are the first line of defense against invading pathogens and are rapidly recruited to the sites of Leishmania inoculation. During Leishmania braziliensis infection, depletion of inflammatory cells significantly increases the ...
Sarah A C Falcão, Tiffany Weinkopff, Benjamin P Hurrell, Fabiana S Celes, Rebecca P Curvelo, Deboraci B Prates, Aldina Barral, Valeria M Borges, Fabienne Tacchini-Cottier, Camila I de Oliveira   +9 more
doaj   +1 more source

Observations on the sandfly (Diptera: Psychodidae) fauna of Além Paraíba state of Minas Gerais, Brazil, and the isolation of a parasite of the Leishmania braziliensis complex from Psychodopygus hirsuta hirsuta

Memorias do Instituto Oswaldo Cruz, 1985
Dissection of 765 sandflies captured in Além Paraíba (the type locality of Leishmania braziliensis) resulted in the isolation, from Psychodopygus hirsuta hirsuta, of a parasite of the Le. braziliensis complex.Foram dissecados 765 flebótomos capturados em
Elizabeth F. Rangel, Lee Ryan, Ralph Lainson, Jeffrey J. Shaw   +3 more
doaj   +1 more source

Infecção natural de Equus asinus por Leishmania braziliensis braziliensis - Bahia, Brasil Natural infection of Equus asinus by Leishmania braziliensis braziliensis - Bahia, Brazil

Memorias do Instituto Oswaldo Cruz, 1986
Em Corte de Pedra, Valença, Bahia, foi encontrado um jumento (Equus asinus), com infecção natural por Leishmania braziliensis braziliensis. O parasito foi isolado de uma lesão localizada na cicatriz da castração e identificado através de anticorpos ...
Julio A. Vexenat, Air C. Barretto, Ana de Cassia O. Rosa, Christiane C. Sales, Albino V. Magalhães   +4 more
doaj   +1 more source

Minor temperature shifts do not affect chromosomal ploidy but cause transcriptomic changes in Leishmania braziliensis promastigotes in vitro [PDF]

Memorias do Instituto Oswaldo Cruz, 2020
BACKGROUND The leishmaniases are complex neglected diseases caused by protozoan parasites of the genus Leishmania. Leishmania braziliensis is the main etiological agent of cutaneous leishmaniasis in the New World. In recent studies, genomic changes such
Nathalia Ballesteros, Nubia M Vásquez, Luz H Patiño, Lissa Cruz-Saavedra, Juan David Ramírez   +4 more
doaj   +1 more source

The activity of azithromycin against Leishmania (Viannia) braziliensis and Leishmania (Leishmania) amazonensis in the golden hamster model A atividade da azitromicina contra a Leishmania (Viannia) braziliensis e a Leishmania (Leishmania) amazonensis no modelo golden hamster

Revista da Sociedade Brasileira de Medicina Tropical, 2007
New therapeutic alternatives against leishmaniasis remain a priority. The activity of azithromycin against Leishmania (Leishmania) major has been previously demonstrated.
Ángel Sinagra, Concepción Luna, David Abraham, Maria del Carmen Iannella, Adelina Riarte, Alejandro J. Krolewiecki   +5 more
doaj   +1 more source