Results 91 to 100 of about 6,508 (210)
ChemistrySelect, Volume 10, Issue 21, June 4, 2025.Leishmaniasis affects over 1 billion people worldwide, with current treatments limited by toxicity and efficacy. This study used machine learning (ML), QSAR, and polypharmacology to identify potential drug candidates, analyzing 12,072 compounds with random forest and XGBoost models.
Laís Salvador do Amaral +7 more
wiley +1 more source
Parasites & Vectors, 2014 Background Two Leishmania major ribosomal proteins L3 (LmL3) and L5 (LmL5) have been described as protective molecules against cutaneous leishmaniasis due to infection with L.
Laura Ramirez +12 more
doaj +1 more source
Brazilian Journal of Medical and Biological Research, 2007 Renal involvement in visceral leishmaniasis (VL) is very frequent but the pathogenesis of this nephropathy is poorly understood. In previous studies using dogs with VL we have detected new immunopathological elements in the glomeruli such as T cells and ...
M.G. Prianti +4 more
doaj +1 more source
Presence of antibodies against Leishmania chagasi in haemodialysed patients
Transactions of the Royal Society of Tropical Medicine and Hygiene, 2009 In the last decades there has been an increase in cases of visceral leishmaniasis complicating the post-transplant phase, mainly following kidney transplantation. The aim of this study was to evaluate the reactivity of haemodialysed patients using IFAT. Blood samples of 310 individuals from Natal, RN, Brazil, were collected and analysed. Data regarding
Souza, Roberto Mascarenhas +6 more
openaire +2 more sources
The carbonic anhydrase enzymes as new targets for the management of neglected tropical diseases
Archiv der Pharmazie, Volume 358, Issue 1, January 2025.The scientific literature dealing with the identification and development of selective inhibitors of the carbonic anhydrases expressed by the protozoans Trypanosoma cruzi (T. cruzi) and Leishmania spp. is reviewed and analyzed, with the aim to sustain the validation process of new classes of drugs useful for the management of neglected tropical ...
Gioele Renzi +3 more
wiley +1 more source
Biomédica: revista del Instituto Nacional de Salud, 2003 Un método sencillo de laboratorio reveló diferencias en el éxito de alimentación de Lutzomyia evansi, el vector de Leishmania chagasi en el norte de Colombia, cuando se alimentó sobre cinco especies de pequeños mamíferos de un foco endémico de ...
Gregory H. Adler +2 more
doaj +1 more source
Antileishmanial Activity of Aldonamides and N-Acyl-Diamine Derivatives
The Scientific World Journal, 2008 A number of lipophilic N-acyl-diamines and aldonamides have been synthesized and tested for their in vitro antiproliferative activity against Leishmania amazonensis and L. chagasi.
Elaine S. Coimbra +7 more
doaj +1 more source
Revista da Sociedade Brasileira de Medicina Tropical, 2011 INTRODUCTION: Domestic dogs are the most important reservoir in the peridomestic transmission cycle of Leishmania (Leishmania) chagasi. The genetic variability of subpopulations of this parasite circulating in dogs has not been thoroughly analyzed in ...
Carlos Eduardo Ribeiro Coutinho +4 more
doaj +1 more source
Biomédica: revista del Instituto Nacional de Salud, 2006 Introducción. La leishmaniosis visceral canina en áreas endémicas de Colombia se constituye en un factor de riesgo para la salud pública, dado el carácter zoonótico de la enfermedad.
José Fernández +7 more
doaj +1 more source
The Anti-Leishmania amazonensis and Anti-Leishmania chagasi Action of Copper(II) and Silver(I) 1,10-Phenanthroline-5,6-dione Coordination Compounds. [PDF]
Pathogens, 2023 Oliveira SSC +5 more
europepmc +1 more source