Results 51 to 60 of about 11,277 (209)

Brazilian flora extracts as source of novel antileishmanial and antifungal compounds [PDF]

, 2008
Natural products have long been providing important drug leads for infectious diseases. Leishmaniasis is a protozoan parasitic disease found mainly in developing countries, and it has toxic therapies with few alternatives. Fungal infections have been the
Calixto, Ivete Arl, Lorenzi, Harri, Melhem, Márcia Sc, Prado, Frederico O, Sartorelli, Patricia, Teixeira, Denise, Tempone, André Gustavo   +6 more
core   +4 more sources

Leishmania chagasi heparin-binding protein: Cell localization and participation in L. chagasi infection

Molecular and Biochemical Parasitology, 2015
Visceral leishmaniasis is a fatal human disease caused by the intracellular protozoan parasite Leishmania chagasi that is captured by host cells in a process involving classics receptors mediated phagocytosis. The search for molecules involved in this process is important to design strategies to disease control.
Thaís Viana Fialho, Martins, Thaís Vieira, de Carvalho, Claudia Vânia Miranda, de Oliveira, Sérgio Oliveira, de Paula, Sílvia Almeida, Cardoso, Leandro Licursi, de Oliveira, Eduardo de Almeida, Marques-da-Silva   +6 more
openaire   +3 more sources

Potential vectors of Leishmaniases in the Environmental Protection Area and Tinguá Federal Biological Reserve, Municipality of Nova Iguaçu, Rio de Janeiro, Brazil

Medical and Veterinary Entomology, Volume 40, Issue 2, Page 246-259, June 2026.
This study was to describe the composition of sand fly fauna, detect potential vectors of Leishmania spp. in the Tinguá district, an ATL endemic, Rio de Janeiro, Brazil. Seven species of vectorial importance in the epidemiological cycle of leishmaniasis was observed: Nyssomyia intermedia, Migonemyia migonei, Pintomyia fischeri, Psychodopygus hirsutus ...
Antônio L. F. Santana, Alfredo C. R. Azevedo, Margarete M. S. Afonso, Bruno M. Carvalho, Vanessa R. Vieira, Simone M. Costa, Júlia S. Silva, Thais A. Pereira, Daniela P. Pereira, Maurício L. Vilela   +9 more
wiley   +1 more source

Anti-leishmania antibodies in cerebrospinal fluid from dogs with visceral leishmaniasis

Brazilian Journal of Medical and Biological Research, 2003
Visceral leishmaniasis in Brazil is caused by Leishmania (Leishmania) chagasi and the dog is its most important reservoir. The clinical features in dogs include loss of weight, lymphadenopathy, renal failure, skin lesions, fever, hypergammaglobulinemia ...
V.M.F. Lima, M.E. Gonçalves, F.A. Ikeda, M.C.R. Luvizotto, M.M. Feitosa   +4 more
doaj   +1 more source

A prime/boost DNA/Modified vaccinia virus Ankara vaccine expressing recombinant Leishmania DNA encoding TRYP is safe and immunogenic in outbred dogs, the reservoir of zoonotic visceral leishmaniasis [PDF]

Previous studies demonstrated safety, immunogenicity and efficacy of DNA/modified vaccinia virus Ankara (MVA) prime/boost vaccines expressing tryparedoxin peroxidase (TRYP) and Leishmania homologue of the mammalian receptor for activated C kinase (LACK ...
Alcami, Antonio, Antoniou, Maria, Begoña Ruiz-Argüello, Maria, Blackwell, Jenefer M., Carson, Connor, Christodoulou, Vasiliki, Courtenay, Orin, Messaritakis, Ippokratis   +7 more
core   +1 more source

Factors Associated With the Emergence and Spread of Visceral Leishmaniasis in the State of São Paulo, Brazil

Zoonoses and Public Health, Volume 73, Issue 4, Page 348-357, June 2026.
ABSTRACT Introduction Visceral leishmaniasis (VL), once considered a rural disease in Brazil, has progressively urbanised, particularly in the state of São Paulo (SSP), where the first urban cases emerged after the detection of the vector Lutzomyia longipalpis in 1997.
Vera Lucia Fonseca de Camargo‐Neves, Guilherme Loureiro Werneck   +1 more
wiley   +1 more source

Immunogold labeling and cerium cytochemistry of the enzyme ecto-5'-nucleotidase in promastigote forms of Leishmania species

Memorias do Instituto Oswaldo Cruz, 1993
We have applied both enzyme cytochemistry and immunological labeling techniques to characterize the enzyme 5'-nucleotidase (5'-Nase), at the ultrastructural level, in promastigote forms of four Leishmania species: Leishmania amazonensis, Leishmania ...
Suzana Corte-Real, Renato Porrozzi, Maria de Nazareth Leal de Meirelles   +2 more
doaj   +1 more source

Atividade leishmanicida e citotoxicidade de constituintes químicos de duas espécies de Annonaceae cultivadas no nordeste do Brasil [PDF]

, 2011
INTRODUCTION: Visceral leishmaniasis is endemic in 88 countries, with a total of 12 million people infected and 350 million at risk. In the search for new leishmanicidal agents, alkaloids and acetogenins isolated from leaves of Annona squamosa and seeds ...
ANDRADE JÚNIOR, Heitor Franco de, BEVILÁQUA, Cláudia Maria Leal, BRASIL, Nilce Viana Gramosa Pompeu de Sousa, COSTA, Igor Rafael Sousa, FALCÃO, Maria José Cajazeiras, MACHADO, Lyeghyna Karla Andrade, MORAIS, Selen Maia de, VILA-NOVA, Nadja Soares   +7 more
core   +2 more sources

Metalloids: Semi as Metals yet Full of Antimicrobial Potential

ChemMedChem, Volume 21, Issue 7, 14 April 2026.
Metalloids such as boron (B), silicon (Si), germanium (Ge), arsenic (As), antimony (Sb), and tellurium (Te) bridge metals and non‐metals, displaying unique chemical versatility. Recent research highlights their diverse antimicrobial and therapeutic potentials, from natural products to synthetic organic and organometallic molcules, underscoring renewed ...
Kevin Böhm, Muhammad Jawad Nasim, Claus Jacob   +2 more
wiley   +1 more source

Evaluation of a New Recombinant K39 Rapid Diagnostic Test for Sudanese Visceral Leishmaniasis. [PDF]

, 2006
A new rK39 rapid diagnostic dipstick test (DiaMed-IT-Leish) was compared with aspiration and a direct agglutination test (DAT) for diagnosis of visceral leishmaniasis (VL) in 201 parasitologically confirmed cases, 133 endemic controls, and in 356 ...
Davidson, R N, Kipngetich, S, Melaku, Y, Mueller, M, O'keeffe, C, Ritmeijer, K   +5 more
core   +1 more source