Results 141 to 150 of about 13,658 (180)

Stages in the life-cycle of Leishmania donovani

Transactions of the Royal Society of Tropical Medicine and Hygiene, 1960
Abstract 1. 1) A technique for observing the phenomena associated with the first stages of infection of cells by flagellates of Leishmania donovani is described. In our experience flagellates enter only monocytes and there is a mutual attraction. They enter body first, and once inside the cell move freely, flagellum first.
R J, PULVERTAFT, G F, HOYLE
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Solution structure of the lipophosphoglycan of Leishmania donovani

Biochemistry, 1992
The three-dimensional solution structure of the repeating -PO4-6Gal beta 1-4Man alpha 1- disaccharide fragment of the lipophosphoglycan (LPG) derived from Leishmania donovani has been determined by use of a combination of homo- and heteronuclear NMR spin coupling constant measurements together with restrained molecular mechanical minimization and ...
S W, Homans, A, Mehlert, S J, Turco
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Cloning and Characterization of Leishmania donovani Telomeres

Experimental Parasitology, 2000
We describe here the cloning and sequence characterization of the absolute termini of several telomeres from the human parasite Leishmania donovani using a vector-adapter protocol. The 3' protruding strand of L. donovani telomeres terminates with the sequence 5'-GGTTAGGGT-OH 3'.
M A, Chiurillo, A E, Beck, T, Devos, P J, Myler, K, Stuart, J L, Ramirez   +5 more
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Heme metabolism in promastigotes of Leishmania donovani

Molecular and Cellular Biochemistry, 1997
Promastigotes of Leishmania donovani (Dd-8 strain) showed presence of important key enzymes of heme synthesizing (delta-aminolevulinic acid synthase and ferrochelatase) and degrading (heme oxygenase and biliverdin reductase) systems, classical leishmanicidal drugs viz allopurinol, amphotericin B, pentamidine and CDRI compound 93/202 inhibited the heme ...
P, Srivastava, G D, Sharma, K K, Kamboj, A K, Rastogi, V C, Pandey   +4 more
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The activity of hydroxynaphthoquinones against Leishmania donovani

Journal of Antimicrobial Chemotherapy, 1992
The hydroxynaphthoquinones, buparvaquone, 250C80 and 56W82, showed high activity in vitro against Leishmania donovani amastigotes in mouse peritoneal macrophages, with ED50 values of 0.05, 2.95 and 13.82 microM, respectively. Fourteen other hydroxynaphthoquinones were tested, of which only 566C80 and 608C86 showed significant activity against ...
S L, Croft, J, Hogg, W E, Gutteridge, A T, Hudson, A W, Randall   +4 more
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Glucose transport in Leishmania donovani promastigotes

Molecular and Biochemical Parasitology, 1984
Mid-log phase Leishmania donovani promastigotes accumulated 2-deoxy-D-glucose (2-DOG) via a carrier mediated transport system, maintaining an apparent Km of 24.4 microM and a Vmax of 3.12 nmol mg-1 protein min-1. D-Glucose but not L-glucose competitively inhibited the 2-DOG transport with an apparent Ki of 18.7 microM.
D, Zilberstein, D M, Dwyer
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Secretion of Sucrase by Leishmania donovani

Journal of Eukaryotic Microbiology, 1994
ABSTRACT. Leishmania donovani promastigotes were collected, washed, resuspended in buffer, and assayed for sucrase activity. No activity was observed in the intact washed cells, but activity was measurable when the cells were permeabilized with Triton X‐100.
J J, Blum, F R, Opperdoes
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Chromosome size polymorphisms of Leishmania donovani

Molecular and Biochemical Parasitology, 1987
A minimum of 22 chromosomes were found in all Leishmania donovani stocks examined by orthogonal field alternation gel electrophoresis (OFAGE). Chromosome sizes ranged from approximately 270 to 4000 kb. Certain chromosomes were polymorphic in size between stocks and chromosomes present in some stocks had no apparent equivalent in others.
R P, Bishop, M A, Miles
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Leishmania donovani: Hemolytic Activity of Promastigotes

Experimental Parasitology, 1994
A hemolytically active component was found to be present in Leishmania donovani promastigotes for the first time. It lysed human and rabbit erythrocytes to varying degrees. The optimal pH for the activity was found to be 5.8. The rate of hemolysis was dependent on both erythrocyte and parasite concentrations.
R, Chakravarty, M C, Sharma, A K, Gupta, N, Prakash, R, Saran   +4 more
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In Vitro Tryptophan Catabolism by Leishmania donovani donovani Promastigotes

The Journal of Protozoology, 1992
ABSTRACT. Metabolism of tryptophan by promastigotes of Leishmania donovani donovani was investigated in cells suspended in a simple buffer solution supplemented with glucose. Metabolites from supernatant and lysed cell pellets were analyzed by capillary gas liquid chromatography and 13C nuclear magnetic resonance spectroscopy, with structural ...
S, Leelayoova, D, Marbury, P M, Rainey, N E, Mackenzie, J E, Hall   +4 more
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