Results 111 to 120 of about 79,414 (305)

Natural Resistance of Leishmania infantum to Miltefosine Contributes to the Low Efficacy in the Treatment of Visceral Leishmaniasis in Brazil

American Journal of Tropical Medicine and Hygiene, 2019
. In India, visceral leishmaniasis (VL) caused by Leishmania donovani has been successfully treated with miltefosine with a cure rate of > 90%. To assess the efficacy and safety of oral miltefosine against Brazilian VL, which is caused by Leishmania ...
J. Carnielli, Renata Monti-Rocha, D. L. Costa, Aretha Molina Sesana, L. Pansini, Marcela Segatto, J. Mottram, C. Costa, S. G. Carvalho, R. Dietze   +9 more
semanticscholar   +1 more source

Comparison of Hemostatic Activity in Canine Leukoreduced Cryoprecipitate, Cryopoor Plasma, and Fresh Plasma

Veterinary Clinical Pathology, Volume 54, Issue 2, Page 120-131, June 2025.
ABSTRACT Background To date, no studies have reported the evaluation of hemostatic activity in canine leukoreduced cryoprecipitate (LR‐CRYO) and leukoreduced cryopoor plasma (LR‐CPP). Objectives We aimed to compare the hemostatic activity of LR‐CRYO and LR‐CPP to leukoreduced fresh plasma (LR‐FP) and to evaluate the preservation of LR‐CRYO by ...
Roberta Perego, Eva Spada, Luciana Baggiani, Giuliano Ravasio, Enrica Zucca, Graziella Vanosi, Giancarlo Ruffo, Daniela Proverbio   +7 more
wiley   +1 more source

Activity and Cell-Death Pathway in Leishmania infantum Induced by Sugiol: Vectorization Using Yeast Cell Wall Particles Obtained From Saccharomyces cerevisiae

Frontiers in Cellular and Infection Microbiology, 2019
Visceral leishmaniasis, caused by Leishmania infantum, is a neglected tropical disease, to which efforts in the innovation of effective and affordable treatments remain limited, despite the rising incidence in several regions of the world.
D. Scariot, Hélito Volpato, N. Fernandes, E. Soares, T. Ueda-Nakamura, B. P. Dias-Filho, Z. Din, E. Rodrigues-Filho, A. Rubira, O. Borges, M. C. Sousa, C. Nakamura   +11 more
semanticscholar   +1 more source

Synthesis and Antileishmanial Activity of 1,2,4,5-Tetraoxanes against Leishmania donovani [PDF]

, 2020
A chemically diverse range of novel tetraoxanes was synthesized and evaluated in vitro against intramacrophage amastigote forms of Leishmania donovani. All 15 tested tetraoxanes displayed activity, with IC50 values ranging from 2 to 45 µm.
Amado, Patrícia, Cabral, Lília, Cojean, Sandrine, Cristiano, Maria De Lurdes, Loiseau, Philippe M., Pomel, Sébastien   +5 more
core   +1 more source

Profiling Serine Hydrolases in the Leishmania Host–Pathogen Interactome Using Cell‐Permeable Activity‐Based Fluorophosphonate Probes

ChemBioChem, Volume 26, Issue 10, May 27, 2025.
Leishmaniasis poses a global health challenge with limited treatment options and rising drug resistance. Activity‐based protein profiling using fluorophosphonate probes is employed to profile serine hydrolases, key virulence factors in Leishmania mexicana.
Jaime A. Isern, Exequiel O. J. Porta, Karunakaran Kalesh, Zisis Koutsogiannis, Davide Cazzola, Ehmke Pohl, Paul W. Denny, Patrick G. Steel   +7 more
wiley   +1 more source

Leishmania infection in cats and dogs housed together in an animal shelter reveals a higher parasite load in infected dogs despite a greater seroprevalence among cats

Parasites & Vectors, 2020
Background An outbreak of leishmaniosis was studied in cats and dogs housed together with no separation in an animal shelter in Israel. Methods The study included recording of clinical signs, serology for Leishmania infection by ELISA, PCR of blood for ...
Gad Baneth, Yaarit Nachum-Biala, Adam Zuberi, Nirit Zipori-Barki, Laor Orshan, Gabriela Kleinerman, Ayelet Shmueli-Goldin, Michel Bellaiche, Monica Leszkowicz-Mazuz, Harold Salant, Daniel Yasur-Landau   +10 more
doaj   +1 more source

Serological survey of Leishmania infantum in apparently healthy dogs in different areas of Spain

Veterinary Medicine and Science, 2023
Background Canine leishmaniosis caused by Leishmania infantum is an endemic disease in Spain. The dog is considered the main reservoir, and the detection of specific serum antibodies against L.
Marta Baxarias, Cristina Mateu, Guadalupe Miró, Laia Solano‐Gallego   +3 more
doaj   +1 more source

Leishmania infantum-specific IFN-γ production in stimulated blood from cats living in areas where canine leishmaniosis is endemic

Parasites & Vectors, 2019
Feline leishmaniosis caused by Leishmania infantum is considered a rare disease in endemic areas, whereas subclinical infections are common. Immune response plays a key role in driving the course of L.
Vito Priolo, P. Martínez-Orellana, M. Pennisi, M. Masucci, D. Prandi, D. Ippolito, F. Bruno, G. Castelli, L. Solano-Gallego   +8 more
semanticscholar   +1 more source

Escherichia coli in the production of biopharmaceuticals

Biotechnology and Applied Biochemistry, Volume 72, Issue 2, Page 528-541, April 2025.
Abstract Escherichia coli has shouldered a massive workload with the discovery of recombinant DNA technology. A new era began in the biopharmaceutical industry with the production of insulin, the first recombinant protein, in E. coli and its use in treating diabetes. After insulin, many biopharmaceuticals produced from E. coli have been approved by the
İbrahim İncir, Özlem Kaplan
wiley   +1 more source

Thymic Microenvironment Is Modified by Malnutrition and Leishmania infantum Infection

Frontiers in Cellular and Infection Microbiology, 2019
Detrimental effects of malnutrition on immune responses to pathogens have long been recognized and it is considered a main risk factor for various infectious diseases, including visceral leishmaniasis (VL).
M. Losada-Barragán, Adriana Umaña-Pérez, Jonathan Durães, Sergio Cuervo-Escobar, A. RODRÍGUEZ-VEGA, F. Ribeiro-Gomes, L. Berbert, F. Morgado, R. Porrozzi, D. Mendes-da-Cruz, Priscila F. Aquino, P. Carvalho, W. Savino, M. Sanchez-Gomez, G. Padrón, P. Cuervo   +15 more
semanticscholar   +1 more source