Results 91 to 100 of about 72,203 (213)

Proteophosophoglycans regurgitated by Leishmania-infected sand flies target the L-arginine metabolism of host macrophages to promote parasite survival [PDF]

, 2009
All natural Leishmania infections start in the skin; however, little is known of the contribution made by the sand fly vector to the earliest events in mammalian infection, especially in inflamed skin that can rapidly kill invading parasites.
Podinovskaia, M, Rogers Matthew, Matthew Rogers, Rogers, Matthew E., Choi Beak-San, Choi, BS, Maria Podinovskaia, Kropf Pascale, Rogers, M, Bates, P, Dillon, R, Ingrid Müller, Kropf, P, Müller, Ingrid, Choi, B. S., Bates Paul, Podinovskaia, M., Kropf, P., Kropf, Pascale, Podinovskaia, Maria, Beak-San Choi, Rogers, Matthew, Dillon, Rod, Rod Dillon, Muller, I, Pascale Kropf, Dillon Rod, Bates, Paul, Müller Ingrid, Podinovskaia Maria, Choi, Beak-San, Paul Bates, Müller, I.   +32 more
core   +1 more source

Synthesis, Anti‐Leishmania amazonensis Activity, Cytotoxicity, and Molecular Docking of Anthranilate–Naphthoquinone Hybrids

ChemistrySelect, Volume 11, Issue 40, 27 October 2026.
New anthranilate–naphthoquinone hybrids display potent inhibition of Leishmania (L.) amazonensis with low host cell toxicity. Molecular docking reveals key interactions with TR, GP63, and PTR1, suggesting a multitarget mechanism that contributes to parasite death.
Eduardo Miranda da Silva Magesfeste, Lidilhone Hamerski, Diego Mendes Nunes, Ana Paula Sotero da Silva Ribeiro, Elvira Maria Saraiva, Magaly Girão Albuquerque, Camilo Henrique da Silva Lima, Bárbara Vasconcellos da Silva   +7 more
wiley   +1 more source

Risk Profiles for Leishmania infantum Infection in Brazil [PDF]

The American Society of Tropical Medicine and Hygiene, 2016
The aim of this study was to characterize risk profiles for Leishmania infantum infection in a population living in an area endemic for visceral leishmaniasis. A cohort study was conducted between January 2004 and December 2006 with the participation of 430 individuals living in the city of Teresina, northeast Brazil, who were initially negative for ...
Erika Barretto, Alves, Carlos Henrique Nery, Costa, Fernando Aécio Amorim, de Carvalho, Maria do Socorro, Pires E Cruz, Guilherme Loureiro, Werneck   +4 more
openaire   +2 more sources

Perillic Acid Synergizes With the Miltefosine Leishmanicidal Effect Against Leishmania amazonensis

Parasite Immunology, Volume 48, Issue 10, October 2026.
ABSTRACT Perillic acid (PA), a monocyclic monoterpene derived from limonene, was evaluated for its leishmanicidal activity alone and in combination with miltefosine, as well as in its microemulsion‐based formulation. PA demonstrated synergistic activity with miltefosine and was effective against both promastigote and amastigote forms of Leishmania ...
C. Ferreira, M. Paschoal, C. L. A. Passos, K. G. H. Silva, K. C. H. Silva, E. M. Saraiva, D. C. Soares   +6 more
wiley   +1 more source

Leishmania infantum intramacrophage lifestyle

, 2020
Microtubule-dependent vacuolar trafficking controls the intramacrophage lifestyle of Leishmania ...
Vanessa Lievin-Le Moal (7518656)
core   +1 more source

Peptide‐Enabled Nanoplatforms for Malaria and Leishmaniasis: From Intracellular Targeting to Translational Diagnostic Perspectives

ChemMedChem, Volume 21, Issue 18, 28 September 2026.
Peptide‐enabled nanoplatforms offer multifunctional strategies for the treatment and diagnosis of malaria and leishmaniasis. Liposomal, polymeric, and metallic nanocarriers, together with cell‐penetrating peptides and parasite‐derived mimotopes, can improve targeted drug delivery, stability, bioavailability, and intracellular localization.
Christian S. Carnero Canales, Ana Clara Lunardi Yagi, Túlio Custódio Reis, Jessica Ingrid Cazorla, Jade Rojas Villar, Marcia A. Graminha, Roxana Yesenia Pastrana Alta, Fernando Rogério Pavan   +7 more
wiley   +1 more source

Leishmania infection in cats and dogs housed together in an animal shelter reveals a higher parasite load in infected dogs despite a greater seroprevalence among cats

Parasites & Vectors, 2020
Background An outbreak of leishmaniosis was studied in cats and dogs housed together with no separation in an animal shelter in Israel. Methods The study included recording of clinical signs, serology for Leishmania infection by ELISA, PCR of blood for ...
Gad Baneth, Yaarit Nachum-Biala, Adam Zuberi, Nirit Zipori-Barki, Laor Orshan, Gabriela Kleinerman, Ayelet Shmueli-Goldin, Michel Bellaiche, Monica Leszkowicz-Mazuz, Harold Salant, Daniel Yasur-Landau   +10 more
doaj   +1 more source

‘Reservoir dogs’: The emerging zoonotic risk associated with European dog imports to the UK

Veterinary Record, Volume 199, Issue 5, Page e238-e249, 5/12 September 2026.
Abstract Background The movement of dogs from continental Europe to the UK poses a growing public health threat due to the associated risk of disease incursions. Current legislation is insufficient to address the risks and pre‐import control measures are focused only on rabies virus and the fox tapeworm Echinococcus multilocularis. Methods We conducted
Poppy Simonson, Tapan Bhattacharyya, Michael A. Miles   +2 more
wiley   +1 more source

Nucleases and Their Inhibitors: Exploring Biological Roles, Industrial Applications, and Challenges in Heterologous Expression

Biotechnology Journal, Volume 21, Issue 9, September 2026.
Graphical Abstract and Lay Summary Intracellular nucleases, depicted as blue circles in a nucleosome, hydrolyze phosphodiester bonds, repair damaged DNA using DNA base excision repair (BER), mismatch repair (MMR), and homologous recombination (HR), and are involved in DNA replication.
Wian Vermeulen, Anton Du Preez van Staden, Leon M. T. Dicks   +2 more
wiley   +1 more source

Selective effects of Euterpe oleracea (açai) on Leishmania (Leishmania) amazonensis and Leishmania infantum

Biomedicine & Pharmacotherapy, 2018
Leishmania (Leishmania) amazonensis and Leishmania infantum (=Leishmania chagasi) are protozoa that cause American cutaneous and visceral leishmaniasis, respectively. These diseases show a high incidence in developing countries such as Brazil. The treatments used for leishmaniasis are still limited due to their high cost and toxicity.
Bruno José Martins, Da Silva, José Rogério, Souza-Monteiro, Herve, Rogez, Maria Elena, Crespo-López, Jose Luiz M, Do Nascimento, Edilene O, Silva   +5 more
openaire   +2 more sources