Results 81 to 90 of about 72,203 (213)

Demographics and travel history of imported and autochthonous cases of leishmaniosis in dogs in the United States and Canada, 2006 to 2019

Journal of Veterinary Internal Medicine, 2021
Background Leishmania infantum infections are reported in foxhounds throughout the United States (US) and Canada, but only rarely in other dog breeds. A seroprevalence report from 2006 documented leishmaniosis in foxhounds (8.9%) tested in the US between
Taylor Estes Gin, Erin Lashnits, James M. Wilson, Edward B. Breitschwerdt, Barbara Qurollo   +4 more
doaj   +1 more source

Amplicon-based next-generation sequencing reveals the co-existence of multiple Leishmania species in patients with visceral leishmaniasis

International Journal of Infectious Diseases, 2022
: Visceral leishmaniasis (VL) is a mammalian protozoal disease propagated in the Americas by female phlebotomine sandflies, mainly caused by Leishmania infantum.
Adriana Castillo-Castañeda, Luz H. Patiño, Marina Muñoz, Martha S. Ayala, Maryi Segura, Jessica Bautista, Maryia V. Shaban, Alberto Paniz-Mondolfi, Juan David Ramírez   +8 more
doaj   +1 more source

Synthesis, Antiparasitic Activity, and ADME Profile of Morpholinephenylbenzamides: A Pharmacological Study Against Chagas Disease and Visceral Leishmaniasis

ChemMedChem, Volume 21, Issue 19, 14 October 2026.
Hit‐to‐lead optimization of morpholinephenylbenzamides reveals key structure–activity relationships against Trypanosoma cruzi and Leishmania infantum. Potency, selectivity, and ADME properties are differentially improved across the series, identifying compounds 20, 24, and 16 as complementary templates for the future design of dual antiparasitic leads.
Danilo Nascimento Farago, Daniela de Melo Resende, Mariza Gabriela Faleiro de Moura Lodi Cruz, Rafaela Marçal Sousa, Rafael Consolin Chelucci, Simone Michelan‐Duarte, Felipe da Silva Mendonça de Melo, Douglas Davison da Silva Oliveira, Paula Derksen Macruz, Alexandra Maria dos Santos Carvalho, Eduardo Jorge Pilau, Izabela Marques Dourado Bastos, Adriano D. Andricopulo, Leonardo L. G. Ferreira, Silvane Maria Fonseca Murta, Celso de Oliveira Rezende Júnior   +15 more
wiley   +1 more source

Application of kDNA as a molecular marker to analyse Leishmania infantum diversity in Portugal.

, 2006
Around the Mediterranean basin Leishmania infantum is an important parasite causing canine leishmaniasis and visceral and cutaneous clinical forms in both immunocompetent and immunocompromised humans.
Cristovão, José Manuel, Pratlong, Francine, Mauricio, Isabel, Cortes, Sofia, Almeida, Ana, Dedet, Jean Pierre, Campino, Lenea   +6 more
core   +1 more source

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, Volume 16, Issue 10, Page 1974-1981, October 2026.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

Is it time to revise the nomenclature of Leishmania?

, 2010
Leishmania is notable for a large number of described species. Molecular phylogenies of Leishmania have increasingly suggested that the number of species could be too large.
Mauricio, Isabel, Gabriele Schönian, Isabel Mauricio, Cupolillo, Elisa, Elisa Cupolillo, Schönian, Gabriele   +5 more
core   +1 more source

Structural Insights Into the Function of Leishmania major Adenylosuccinate Lyase

Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 10, Page 1686-1701, October 2026.
ABSTRACT One of several intriguing aspects of kinetoplastid biochemistry is the complete dependence on host purines and purine recycling due to the lack of a de novo purine biosynthesis pathway. Adenylosuccinate lyase (ASL, EC 4.3.2.2) is a key enzyme in the purine synthesis pathway responsible for the conversion of adenylosuccinate into adenosine ...
Ivan R. e Silva, Monique Mantovani, Maria E. S. D. Lino, Aline O. Albuquerque, João H. M. da Silva, Ronaldo A. P. Nagem, Adriana L. Rojas, Geraldo R. Sartori, Eduardo Horjales, David Campbell, Otavio H. Thiemann   +10 more
wiley   +1 more source

Transmission potential of paromomycin-resistant Leishmania infantum and Leishmania donovani

Journal of Antimicrobial Chemotherapy, 2019
AbstractObjectivesFormer studies demonstrated quick selection of paromomycin resistance for Leishmania infantum and Leishmania donovani accompanied by increased fitness. The present study aimed to interpret these findings in an epidemiological context by comparing infection of WT and experimentally derived paromomycin-resistant strains in the sand fly ...
G Caljon, P Volf, L Maes, J Sadlova, H Aslan, L Van Bockstal, S Hendrickx   +6 more
openaire   +3 more sources

Coumarin‐Benzimidazole Hybrids as Multitarget Scaffolds for Antileishmanial Drug Discovery

ChemistrySelect, Volume 11, Issue 38, 13 October 2026.
Coumarin‐benzimidazole hybrids emerge as promising antileishmanial agents through virtual screening against essential Leishmania enzymes, Cathepsin B (CatB), and N‐myristoyltransferase (NMT). Molecular docking and dynamics simulations reveal highly stable target interactions that surpass the reference drug miltefosine (MTF).
Fernanda Melo Jucá, Damião Sampaio de Sousa, Caio Henrique Alexandre Roberto, Márcia Machado Marinho, Emmanuel Silva Marinho   +4 more
wiley   +1 more source

Genetic diversity in the Leishmania donovani complex. [PDF]

The Leishmania donovani complex comprises four described species: L. donovani, L. archibaldi, L. infantum and L. chagasi. L. chagasi is the only New World species and has been considered similar to L.
Mauricio, Isabel Larguinho
core   +1 more source