Results 101 to 110 of about 69,551 (215)

Clinical outcome, imaging and histopathological findings of liver cirrhosis in dogs

Veterinary Record Case Reports, Volume 14, Issue 3, August 2026.
Abstract Cirrhosis is a severe and irreversible condition resulting from chronic liver injury, characterised by extensive fibrosis and regenerative nodules. This report describes three dogs with cirrhosis. The main clinical findings included ascites, reduced body condition score and inappetence. Anaemia, thrombocytopenia, hypoalbuminaemia, and elevated
Wanderson Feliciano Duarte da Silva, Roger Fernando Neves da Silva, Edson Moleta Colodel, Pedro Eduardo Brandini Nespóli, Valeria Regia Franco Sousa   +4 more
wiley   +1 more source

Unusual report of an immunocompetent patient with atypical cutaneous leishmaniasis caused by Leishmania (Leishmania) infantum in Minas Gerais, Brazil [PDF]

Revista da Sociedade Brasileira de Medicina Tropical
Cutaneous leishmaniasis is endemic in Minas Gerais, Brazil; however, data on the circulating species remain limited. This study identified Leishmania species in he skin samples of patients in Montes Claros using molecular methods.
Rebeca Mendes Rocha, Jackeline Maria de Sousa Lima Lopes, Emanuelle de Moura Santos Xavier, Rosanna Lorrane Francisco dos Reis Matos, Dayse Marcielle de Souza Lopes, Flávia Carvalho Bitencourt de Oliveira, Felipe Dutra Rêgo, José Dilermando Andrade, Célia Maria Ferreira Gontijo, Leandro de Freitas Teles, Jamille Fernandes Lula, Luciano Freitas Fernandes, André Luiz Sena Guimarães, Ana Paula Venuto Moura, Thallyta Maria Vieira, Sílvio Fernando Guimarães de Carvalho   +15 more
doaj   +1 more source

Leishmania infantum

, 2018
El Atlas Comentado sobre Protozoología presenta imágenes que pertenecen a protozoos parásitos que con mayor frecuencia se diagnostican en la región por parte de los equipos de docentes-investigadores pertenecientes al Centro de Estudios Parasitológicos y de Vectores (CEPAVE-CONICET-UNLP) y al Laboratorio de Inmunoparasitología (LAINPA-FCV-UNLP).
Dellarupe, Andrea, Eiras, Diego Fernando, Venturini, María Cecilia   +2 more
openaire   +1 more source

Identification of a Benzenesulfonylpiperazine Derivative With In Vivo Efficacy Against Visceral Leishmaniasis

Chemical Biology &Drug Design, Volume 108, Issue 2, August 2026.
This work highlights the satisfactory pharmacokinetic profile of two benzenesulfonylpiperazine lead candidates, followed by in vivo assessment in a murine model of visceral leishmaniasis. This assessment identified compound 2 as moderately active at a lower dose, but its efficacy increased at higher doses, though with concerns regarding safety.
Thibault Joseph William Jacques Dit Lapierre, Mariza Gabriela Faleiro de Moura Lodi Cruz, Guilherme Freitas de Lima Hercos, Rafael Consolin Chelucci, Simone Michelan‐Duarte, Gisele Barbosa, Analu R. Costa, Miguel Angel Chávez‐Fumagalli, Paula Derksen Macruz, Eduardo Jorge Pilau, Leonardo L. G. Ferreira, Adriano D. Andricopulo, Silvane Maria Fonseca Murta, Celso de Oliveira Rezende Júnior   +13 more
wiley   +1 more source

Treatment of Leishmania infantum Infections in Dogs

Microorganisms
Dogs are reservoir hosts of the zoonotic parasite Leishmania infantum, the causative agent of canine leishmaniosis. Antiparasitic drugs that are commonly used in dogs include allopurinol, miltefosine, and meglumine antimoniate. Treatment success is characterized by an improvement of disease signs, reduction in parasite load, as well as prevention of ...
Melanie Kaempfle, Katrin Hartmann, Michèle Bergmann   +2 more
openaire   +3 more sources

From genomes to vaccines: Leishmania as a model:Leishmania as a model [PDF]

, 2002
The 35 Mb genome of Leishmania should be sequenced by late 2002. It contains approximately 8500 genes that will probably translate into more than 10 000 proteins.
Vilo, Jaak, Freeman, Tom, Lange, Uta, Vetrie, David, Blackwell, Jenefer M., Almeida, Renata, Ivens, Alasdair, Levick, Mark, Stober, Carmel, Blackwell, Jenefer M, Norrish, Alan, McCann, Sharon   +11 more
core   +1 more source

Modeled structure of trypanothione reductase of Leishmania infantum

BMB Reports, 2008
Trypanothione reductase is an important target enzyme for structure-based drug design against Leishmania. We used homology modeling to construct a three-dimensional structure of the trypanothione reductase (TR) of Leishmania infantum. The structure shows acceptable Ramachandran statistics and a remarkably different active site from glutathione ...
Bishal K, Singh, Nandini, Sarkar, M V, Jagannadham, Vikash K, Dubey   +3 more
openaire   +3 more sources

Accelerated healing of cutaneous leishmaniasis in non-healing BALB/c mice using water soluble amphotericin B-polymethacrylic acid. [PDF]

, 2011
Cutaneous leishmaniasis (CL) is a neglected tropical disease that causes prominent skin scaring. No water soluble, non-toxic, short course and low cost treatment exists. We developed a new water soluble amphotericin B-polymethacrylic acid (AmB-PMA) using
Müller, Ingrid, Sunil Shaunak, Shaunak, Sunil, Rogers, Matthew, Naresh, Kikkeri, Matthew Rogers, Naresh, K, Teo, I, Mueller, I, Harris, Debra, Debra Harris, Harris, D, Corware, Karina, Shaunak, S, Karina Corware, Kikkeri Naresh, Teo, Ian, Rogers, M, Ian Teo, Ingrid Müller, Corware, K   +20 more
core   +1 more source

A rare case of lingual mucosal leishmaniasis caused by reactivation of Leishmania infantum infection

BMC Infectious Diseases
Background Leishmania infantum is the only prevalent Leishmania species in Europe and manifesting predominantly as cutaneous or visceral leishmaniasis, whereas new world species like Leishmania (L.) braziliensis are well known pathogens in mucocutaneous ...
Yannik Eggers, Martha Holtfreter, Irmela Müller-Stoever, Johannes Mischlinger, Andreas Hammacher, Bernhard Hemmerlein, Alexander Kreuter, Frank Oellig, Dennis Tappe, Tom Luedde, Torsten Feldt, Hans Martin Orth   +11 more
doaj   +1 more source

Development of a novel ddPCR assay for the simultaneous detection of the protozoan parasites Leishmania infantum and Leishmania tarentolae

Parasites & Vectors
Background Leishmaniases, caused by protozoan parasites of the genus Leishmania, are vector-borne diseases occurring mainly in the tropics and subtropics of the world, as well as in the Mediterranean Basin. In this area, the mammalian pathogen Leishmania
Alessandro Alvaro, Giulia Maria Cattaneo, Ilaria Varotto-Boccazzi, Riccardo Molteni, Jairo Alfonso Mendoza-Roldan, Matteo Brilli, Matilde Silvia Conconi, Virginia Giovagnoli, Alessandro Manenti, Domenico Otranto, Claudio Bandi, Sara Epis   +11 more
doaj   +1 more source