In vitro and in vivo antileishmanial efficacy of a combination therapy of diminazene and artesunate against Leishmania donovani in BALB /c mice [PDF]
The in vitro and in vivo activity of diminazene (Dim), artesunate (Art) and combination of Dim and Art (Dim-Art) against Leishmania donovani was compared to reference drug; amphotericin B. IC50 of Dim-Art was found to be $2.28 \pm 0.24 \mu$ g/mL while those of Dim and Art were $9.16 \pm 0.3 \mu$ g/mL and $4.64 \pm 0.48 \mu$ g/mL respectively.
arxiv +1 more source
Leishmanioses are vector-borne diseases caused by Leishmania spp., which are transmitted by phlebotomine sand flies (Diptera, Psychodidae). The recent reports in humans of Leishmania tarentolae, which is primarily found in cold-blooded animals, and ...
M. Latrofa+4 more
semanticscholar +1 more source
Background Neutrophils play an immunomodulatory role through the release of neutrophil extracellular traps (NETs). NETs are released in response to Leishmania infection, but the mechanism of NET extrusion has not been elucidated.
Furong Wei+6 more
doaj +1 more source
Transient superdiffusion and long-range correlations in the motility patterns of trypanosomatid flagellate protozoa [PDF]
We report on a diffusive analysis of the motion of flagellate protozoa species. These parasites are the etiological agents of neglected tropical diseases: leishmaniasis caused by Leishmania amazonensis and Leishmania braziliensis, African sleeping sickness caused by Trypanosoma brucei, and Chagas disease caused by Trypanosoma cruzi.
arxiv +1 more source
Cryptic
Background Visceral leishmaniasis (VL) is a protozoan diseases caused in Europe by Leishmania (L.) infantum. Asymptomatic Leishmania infection is more frequent than clinically apparent disease.
Rubino Raffaella+10 more
doaj +1 more source
Antiparasitic effect of synthetic aromathecins on Leishmania infantum [PDF]
Abstract Background Canine leishmaniasis is a zoonotic disease caused by Leishmania infantum, being the dogs one of the major reservoirs of human visceral leishmaniasis. DNA topology is a consolidated target for drug discovery. In this regard, topoisomerase IB – one of the enzymes controlling DNA topology – has been poisoned by hundreds of compounds ...
Rosa M. Reguera+6 more
openaire +5 more sources
Estimating the concentration of gold nanoparticles incorporated on Natural Rubber membranes using Multi-Level Starlet Optimal Segmentation [PDF]
This study consolidates Multi-Level Starlet Segmentation (MLSS) and Multi-Level Starlet Optimal Segmentation (MLSOS), techniques for photomicrograph segmentation that use starlet wavelet detail levels to separate areas of interest in an input image.
arxiv +1 more source
Leishmania (infantum) chagasi in canine urinary sediment [PDF]
Canine visceral leishmaniasis (CVL) is difficult to diagnosis, mainly due to the presence of asymptomatic animals, the diversity of clinical symptoms and the difficulty in obtaining diagnostic evidence of high sensitivity and specificity. The purpose of this study was to diagnose CVL in urinary sediment of 70 dogs of different breeds, sexes and ages ...
Mendonça, Ivete Lopes de+2 more
openaire +5 more sources
Proteome Profiling of Leishmania Infantum Promastigotes
ABSTRACT. A proteome analysis of the promastigote stage of the trypanosomatid parasite Leishmania infantum (MON‐1 zymodeme) is described here for the first time. Total protein extracts were prepared at early logarithmic and stationary phases of replicate axenic cultures and processed by 2D electrophoresis (pH 3–10).
Alcolea, Pedro J.+2 more
openaire +4 more sources
Paf-Metabolic Enzymes and Paf-like Activity in and Promastigotes
Leishmania spp are obligate intracellular protozoan parasites of the mononuclear phagocyte system that cause a spectrum of diseases known as leishmaniasis.
P. Chatzovoulos+5 more
doaj +1 more source