Results 1 to 10 of about 13,596 (96)

Visceral leishmaniasis patients display altered composition and maturity of neutrophils as well as impaired neutrophil effector functions [PDF]

, 2016
Immunologically, active visceral leishmaniasis (VL) is characterised by profound immunosuppression, severe systemic inflammatory responses and an impaired capacity to control parasite replication.
Adem, E, Cruz Cervera, E, Diro, E, Getahun, M, Hailu, A, Kropf, P, Lemma, M, Melkamu, R, Mengesha, B, Mesfin, G, Modolell, M, Muller, I, Munder, M, Skhedy, Z, Tajebe, F, Takele, Y, Van der Auwera, G, Yardley, V, Yeshanew, A, Yizengaw, E   +19 more
core   +13 more sources

Immunization with antigenic extracts of Leishmania associated with Montanide ISA 763 adjuvant induces partial protection in BALB/c mice against Leishmania (Leishmania) amazonensis infection [PDF]

, 2014
Background/Purpose: A proper adjuvant has a relevant role in vaccine formulations to generate an effective immune response. In this study, total Leishmania antigen (TLA) formulated with Montanide ISA 763 or R848 as adjuvants were evaluated as a first ...
Cargnelutti, Diego Esteban, Celedon, Verónica, Cuello Carrión, Fernando Darío, Garcia Bustos, Maria Fernanda, Morea, Gastón, Salomón, María Cristina, Scodeller, Eduardo   +6 more
core   +1 more source

Resistance of Leishmania (Leishmania) amazonensis and Leishmania (Viannia) braziliensisto nitric oxide correlates with disease severity in Tegumentary Leishmaniasis [PDF]

, 2007
Background Nitric oxide (NO•) plays a pivotal role as a leishmanicidal agent in mouse macrophages. NO• resistant Escherichia coli and Mycobacterium tuberculosis have been associated with a severe outcome of these diseases.
Angela Giudice, Ilza Camada, Paulo TG Leopoldo, Júlia MB Pereira, Lee W Riley, Mary E Wilson, John L Ho, Amelia Ribeiro de Jesus, Edgar M Carvalho, Roque P Almeida, AL Bittencourt, H Louzir, M Castes, PD Marsden, JM Costa, J Alexander, J Alexander, FY Liew, P Scott, ME Wilson, FY Liew, FY Liew, C Bogdan, SJ Green, TG Evans, J Assreuy, HW Murray, S Nicholson, KR Gantt, C Bogdan, J Mauel, PR Romao, WJ Paramchuk, SR Meshnick, TJ Vickers, MP Levick, MA Miller, FC Fang, E Cupolillo, ME Wilson, C Bogdan, HW Murray, NE Reiner, P Scott, I Vouldoukis, P Kumar, C Bogdan, M Barral-Netto, ME Wilson, E Cupolillo, SM Cupolilo, A Schriefer, KA Rockett, I Vouldoukis, NK Basu, M Genestra, M Genestra, R Hanano, K Kawakami, DR Pakianathan, FM Balestieri, A Descoteaux, C Nathan, A Jardim   +63 more
core   +1 more source

Impact of tumor necrosis factor receptor p55 deficiency in susceptibility of C57BL/6 mice to infection with Leishmania (Leishmania) amazonensis [PDF]

, 2014
Tumor necrosis factor (TNF) is involved in host resistance to several intracellular pathogens. Although the critical role of TNF receptor (TNFR)p55 in Leishmania (Leishmania) major infection has been demonstrated, the impact of TNFRp55 deficiency on L ...
Cargnelutti, Diego Esteban, Celedon, Verónica, Cuello Carrión, Fernando Darío, Di Genaro, María Silvia, Gea, Susana, Salomón, María Cristina, Scodeller, Eduardo   +6 more
core   +1 more source

Changes to cholesterol trafficking in macrophages by Leishmania parasites infection [PDF]

, 2017
Leishmania spp. are protozoan parasites that are transmitted by sandfly vectors during blood sucking to vertebrate hosts and cause a spectrum of diseases called leishmaniases.
Anderson, Andrade-Neto, Antoine, Bansal, Berman, Blanchette-Mackie, Burack, Carstea, Carvalho, Chakraborty, Chattopadhyay, Collins, Coombs, Coppens, De Cicco, Desvergne, Duclos, Edwards, Ehrenman, Fernandes, Ghosh, Ghosh, Ghosh, Ginger, Ginger, Goldstein, Groener, Hamid, Hart, Ikonen, Infante, Johndrow, Kima, Kima, Kok, Kwon, Lal, Lecoeur, Lippuner, Livak, Majumder, Maxfield, McIntosh, Misslitz, Naureckiene, Neufeld, Osorio y Fortea, Ovalle-Bracho, Paape, Paape, Pereira, Portugal, Pucadyil, Rabhi, Redgrave, Roberts, Rosenzweig, Rub, Russell, Saunders, Sen, Shamshiev, Soares, Sorensen, Tetley, Tewary, Tontonoz, Weinheber   +67 more
core   +2 more sources

Native rodent species are unlikely sources of infection for Leishmania (Viannia) braziliensis along the Transoceanic Highway in Madre de Dios, Peru. [PDF]

, 2014
An estimated 2.3 million disability-adjusted life years are lost globally from leishmaniasis. In Peru's Amazon region, the department of Madre de Dios (MDD) rises above the rest of the country in terms of the annual incidence rates of human leishmaniasis.
Conrad, Patricia A, De Los Santos, Maxy, Ghersi, Bruno M, Lescano, Andres G, Mazet, Jonna AK, Montgomery, Joel M, Razuri, Hugo, Shender, Lisa A   +7 more
core   +4 more sources

Emerging Role for the PERK/eIF2α/ATF4 in Human Cutaneous Leishmaniasis. [PDF]

, 2017
Leishmania parasites utilize adaptive evasion mechanisms in infected macrophages to overcome host defenses and proliferate. We report here that the PERK/eIF2α/ATF4 signaling branch of the integrated endoplasmic reticulum stress response (IERSR) is ...
Aktas, B.H., Calegari-Silva, T.C., Cavalcanti, Á., Dias-Teixeira, K.L., Fasel, N., Gomes, C.M., Lopes, U.G., Medina, J.M., Pereira, RMS, Real, F., Santana, AKM, Silva, J.S., Teteo, N., Vivarini, Á.C.   +13 more
core   +3 more sources

Leishmania amazonensis promastigotes in 3D Collagen I culture: an in vitro physiological environment for the study of extracellular matrix and host cell interactions [PDF]

, 2014
Leishmania amazonensis is the causative agent of American cutaneous leishmaniasis, an important neglected tropical disease. Once Leishmania amazonensis is inoculated into the human host, promastigotes are exposed to the extracellular matrix (ECM) of the ...
Bruno Pontes, Camila F.A. Pereira, Debora B. Petropolis, Fernando C. Silva-Filho, Juliany C.F. Rodrigues, Nathan B. Viana   +5 more
core   +2 more sources

Role of protein kinase R in the killing of Leishmania major by macrophages in response to neutrophil elastase and TLR4 via TNF and IFN [PDF]

, 2014
In cutaneous leishmaniasis, Leishmania amazonensis activates macrophage double-stranded, RNA-activated protein kinase R (PKR) to promote parasite growth. In our study, Leishmania major grew normally in RAW cells, RAW-expressing dominant-negative PKR (PKR-
Abu-Dayyeh I., Aislan de Carvalho Vivarini, Ana Paula C. A. Lima, Da Silva R., Danelli M. G., Jeremy C. Mottram, Marilia S. Faria, Nylen S., Tereza C. Calegari‐Silva, Ulisses Gazos Lopes, Vivarini Ade C.   +10 more
core   +1 more source

Characterization of oxidative stress in Leishmaniasis-infected or LPS-stimulated macrophages using electrochemical impedance spectroscopy [PDF]

, 2010
The physiological changes caused by external stimuli can be employed as parameters to study pathogen infection in cells and the effect of drugs. Among analytical methods, impedance is potentially useful to give insight into cellular behavior by studying ...
Coste, Agnès, Fabre, Paul-Louis, Launay, Jérôme, Nepveu, Françoise, Reybier, Karine, Ribaut, Clothilde   +5 more
core   +2 more sources