Results 11 to 20 of about 8,781 (205)

Differentiation of Leishmania (L.) infantum, Leishmania (L.) amazonensis and Leishmania (L.) mexicana Using Sequential qPCR Assays and High-Resolution Melt Analysis [PDF]

Microorganisms, 2020
Leishmania protozoa are the etiological agents of visceral, cutaneous and mucocutaneous leishmaniasis. In specific geographical regions, such as Latin America, several Leishmania species are endemic and simultaneously present; therefore, a diagnostic ...
Marcello Ceccarelli, Aurora Diotallevi, Gloria Buffi, Mauro De Santi, Edith A. Fernández-Figueroa, Claudia Rangel-Escareño, Said A. Muñoz-Montero, Ingeborg Becker, Mauro Magnani, Luca Galluzzi   +9 more
doaj   +4 more sources

Assessing the effects of Leishmania (Leishmania) infantum and L. (L.) amazonensis infections in macrophages using a quantitative proteome approach

Experimental Parasitology, 2022
Leishmania (Leishmania) infantum is the causative agent of visceral leishmaniasis, while L. (L.) amazonensis is associated with localized cutaneous and diffuse leishmaniasis, which can affect different organ tissues leading to visceral manifestations in some hosts.
Ivana H.R. Oliveira, Frank Kjeldsen, Marcella N. Melo-Braga, Thiago Verano-Braga, Hélida M. de Andrade   +4 more
openaire   +4 more sources

Sphingolipid degradation in Leishmania (Leishmania) amazonensis.

PLoS Neglected Tropical Diseases, 2012
BackgroundHuman leishmaniasis is caused by more than 20 Leishmania species and has a wide range of symptoms. Our recent studies have demonstrated the essential role of sphingolipid degradation in the virulence of Leishmania (Leishmania) major, a species ...
Agiesh Balakrishna Pillai, Wei Xu, Ou Zhang, Kai Zhang   +3 more
doaj   +2 more sources

Analysis and chromosomal mapping of Leishmania (Leishmania) amazonensis amastigote expressed sequence tags [PDF]

Memorias do Instituto Oswaldo Cruz, 2007
The characterization of expressed sequence tags (ESTs) generated from a cDNA library of Leishmania (Leishmania) amazonensis amastigotes is described. The sequencing of 93 clones generated new L. (L.) amazonensis ESTs from which 32% are not related to any
Luciana Girotto Gentil, Fernanda Lasakosvitsch, José Franco da Silveira, Márcia Regina Machado dos Santos, Clara Lúcia Barbiéri   +4 more
doaj   +4 more sources

Experimental model of chronic osteomyelitis caused by Leishmania (L) amazonensis [PDF]

Acta Tropica, 2006
Experimental animal models have been used for the study of the physiopathogenesis of leishmaniasis, on some occasions with success, while in other situations such as bone alterations that accompany tegumentary leishmaniasis, especially in diffuse cutaneous form (DCL), the mechanisms are still unknown.
Af Ali U M, Costa, Ana L, Abreu, Claudia M C, Gomes, Ana C R, Saldanha, A, Barral, Jackson M L, Costa, Carlos E P, Corbett   +6 more
openaire   +3 more sources

Cloning and characterisation of a cysteine proteinase gene expressed in amastigotes of Leishmania (L.) amazonensis

International Journal for Parasitology, 2003
The present study describes the cloning and characterisation of a gene encoding a cysteine proteinase isoform, Llacys1, expressed in amastigote forms of Leishmania (L.) amazonensis. Recombinant clones containing the Llacys1 gene were isolated from genomic DNA by PCR amplification and screening of an amastigote cDNA library.
Fernanda, Lasakosvitsch, Luciana Girotto, Gentil, Márcia Regina Machado, dos Santos, José Franco, da Silveira, Clara Lúcia, Barbiéri   +4 more
openaire   +3 more sources

Arginase expression modulates nitric oxide production in Leishmania (Leishmania) amazonensis. [PDF]

PLoS ONE, 2017
Arginase is an enzyme that converts L-arginine to urea and L-ornithine, an essential substrate for the polyamine pathway supporting Leishmania (Leishmania) amazonensis replication and its survival in the mammalian host.
Stephanie Maia Acuña, Juliana Ide Aoki, Maria Fernanda Laranjeira-Silva, Ricardo Andrade Zampieri, Juliane Cristina Ribeiro Fernandes, Sandra Marcia Muxel, Lucile Maria Floeter-Winter   +6 more
doaj   +2 more sources

VAPA mediates lipid exchange between Leishmania amazonensis and host macrophages. [PDF]

PLoS Pathogens
Leishmania is a vacuolar pathogen that replicates within parasitophorous vacuoles inside host phagocytes. To promote its replication, Leishmania relies on a panoply of strategies to acquire macromolecules such as lipids from host macrophages.
Ilona Gdovinova, Albert Descoteaux
doaj   +2 more sources

Leishmania (L.) amazonensis LaLRR17 increases parasite entry in macrophage by a mechanism dependent on GRP78. [PDF]

Parasitology, 2023
AbstractLeishmaniases affect 12 million people worldwide. They are caused by Leishmania spp., protozoan parasites transmitted to mammals by female phlebotomine flies. During the life cycle, promastigote forms of the parasite live in the gut of infected sandflies and convert into amastigotes inside the vertebrate macrophages.
Peña MS, Tang FHF, Franco FAL, Rodrigues AT, Carrara GMP, Araujo TLS, Giordano RJ, Palmisano G, de Camargo MM, Uliana SRB, Stolf BS.   +10 more
europepmc   +4 more sources

Metabolomic Profile of BALB/c Macrophages Infected with Leishmania amazonensis: Deciphering L-Arginine Metabolism [PDF]

International Journal of Molecular Sciences, 2019
Background: Leishmaniases are neglected tropical diseases that are caused by Leishmania, being endemic worldwide. L-arginine is an essential amino acid that is required for polyamines production on mammal cells. During Leishmania infection of macrophages, L-arginine is used by host and parasite arginase to produce polyamines, leading to parasite ...
Sandra Marcia Muxel, Maricruz Mamani-Huanca, Juliana Ide Aoki, Ricardo Andrade Zampieri, Lucile Maria Floeter-Winter, Ángeles López-Gonzálvez, Coral Barbas   +6 more
openaire   +3 more sources