Results 11 to 20 of about 14,623 (258)

In vitro and in vivo activity of meglumine antimoniate produced atFarmanguinhos-Fiocruz, Brazil, against Leishmania (Leishmania)amazonensis, L (L.) chagasi and L (Viannia) braziliensis [PDF]

Memórias do Instituto Oswaldo Cruz, 2008
The leishmanicidal activity of four batches of meglumine antimoniate, produced in Farmanguinhos-Fiocruz, Brazil (TAMs), was assessed and compared to Glucantime-Aventis Pharma Ltda. Using the amastigote-like in vitro model, the active concentrations of Sb v varied from 10microg/ml to 300microg/ml for L.
Eliane de Morais-Teixeira, Alcione Silva de Carvalho, Jorge CS da Costa, Silvio Luiz Duarte, Jorge Souza Mendonça, Núbia Boechat, Ana Rabello   +6 more
  +9 more sources

Py-CoMFA, docking, and molecular dynamics simulations of Leishmania (L.) amazonensis arginase inhibitors. [PDF]

Sci Rep
AbstractLeishmaniasis is a disease caused by a protozoan of the genus Leishmania, affecting millions of people, mainly in tropical countries, due to poor social conditions and low economic development. First-line chemotherapeutic agents involve highly toxic pentavalent antimonials, while treatment failure is mainly due to the emergence of drug ...
Camargo PG, Dos Santos CR, Girão Albuquerque M, Rangel Rodrigues C, Lima CHDS.   +4 more
europepmc   +4 more sources

Immucillins Impair Leishmania (L.) infantum chagasi and Leishmania (L.) amazonensis Multiplication In Vitro

PLOS ONE, 2015
Chemotherapy against visceral leishmaniasis is associated with high toxicity and drug resistance. Leishmania parasites are purine auxotrophs that obtain their purines from exogenous sources. Nucleoside hydrolases release purines from nucleosides and are drug targets for anti-leishmanial drugs, absent in mammal cells.
Elisângela Oliveira de Freitas, Dirlei Nico, Rong Guan, José Roberto Meyer‐Fernandes, Keith Clinch, Gary B. Evans, Peter C. Tyler, Vern L. Schramm, M Palatnik   +8 more
openalex   +5 more sources

Resistance of Leishmania (Leishmania) amazonensis and Leishmania (Viannia) braziliensis to nitric oxide correlates with disease severity in Tegumentary Leishmaniasis [PDF]

BMC Infectious Diseases, 2007
Background Nitric oxide (NO•) plays a pivotal role as a leishmanicidal agent in mouse macrophages. NO• resistant Escherichia coli and Mycobacterium tuberculosis have been associated with a severe outcome of these diseases.
Carvalho Edgar M, de Jesus Amelia, Ho John L, Wilson Mary E, Riley Lee W, Leopoldo Paulo TG, Pereira Júlia MB, Camada Ilza, Giudice Angela, Almeida Roque P   +9 more
doaj   +2 more sources

N-acetyl-L-cysteine reduces Leishmania amazonensis-induced inflammation in BALB/c mice [PDF]

BMC Veterinary Research, 2020
AbstractBackgroundLeishmaniasis is a emergent disease characterized by different clinical manifestations in both humans and dogs. Predominant clinical features of cutaneous leishmaniasis are ulcerative painless skin lesions. Several data reported that pain is associated with human and dog leishmaniasis, out with areas of painless ulcerative lesions per
Rosalia Crupi, Enrico Gugliandolo, Rosalba Siracusa, Daniela Impellizzeri, Marika Cordaro, Rosanna Di Paola, Domenico Britti, Salvatore Cuzzocrea   +7 more
openalex   +4 more sources

Differentiation of Leishmania (L.) infantum, Leishmania (L.) amazonensis and Leishmania (L.) mexicana Using Sequential qPCR Assays and High-Resolution Melt Analysis

Microorganisms, 2020
Leishmania protozoa are the etiological agents of visceral, cutaneous and mucocutaneous leishmaniasis. In specific geographical regions, such as Latin America, several Leishmania species are endemic and simultaneously present; therefore, a diagnostic ...
Marcello Ceccarelli, Aurora Diotallevi, Gloria Buffi, Mauro De Santi, Edith A. Fernández-Figueroa, Claudia Rangel-Escareño, Said A. Muñoz-Montero, Ingeborg Becker, Mauro Magnani, Luca Galluzzi   +9 more
doaj   +3 more sources

Evaluation of a chloroquine hydrogel for topical treatment of leishmaniasis in BALB/c mice infected with <i>Leishmania</i> (<i>L.</i>) <i>amazonensis</i>. [PDF]

3 Biotech
Branco Junior AG, Fialho SN, de Jesus Gouveia A, Dos Santos Ferreira A, Do Nascimento Martinez L, da Silva Paula do Nascimento W, Rossi NRDLP, da Silva MA, Lemke MFM, Zepon KM, Kanis LA, Dos Santos Ribeiro L, Teles CBG.   +12 more
europepmc   +3 more sources

Peptides as a Therapeutic Alternative Against Leishmaniasis: A Scoping Review. [PDF]

Chem Biol Drug Des
This scoping review of 79 studies identified 231 antimicrobial peptides with anti‐Leishmania activity, including natural‐derived and synthetic peptides (inspired by natural sources or developed through rational design). Most were evaluated in vitro against promastigote and/or amastigote forms, with synthetic peptides showing a more promising effect ...
da Veiga Oliveira ME, Dyminski Parente Ribeiro E, Guenther OHP, Tomiotto-Pellissier F.   +3 more
europepmc   +2 more sources

Imidazolium salts as an alternative for anti-Leishmania drugs: Oxidative and immunomodulatory activities

Frontiers in Immunology, 2023
In this study we explored the previously established leishmanicidal activity of a complementary set of 24 imidazolium salts (IS), 1-hexadecylimidazole (C16Im) and 1-hexadecylpyridinium chloride (C16PyrCl) against Leishmania (Leishmania) amazonensis and ...
Fernanda Giesel Baldissera, Fernanda Giesel Baldissera, Tiago Fazolo, Tiago Fazolo, Matheus Brasil da Silva, Paulo Cesar de Santana Filho, Vinícius Demétrio da Silva, David Max Rivillo Perez, Joice Sandra Klitzke, Eduardo Giovanni de Oliveira Soares, Luiz Carlos Rodrigues Júnior, Luiz Carlos Rodrigues Júnior, Alessandra Peres, Alessandra Peres, Eliane Dallegrave, Kely Campos Navegantes-Lima, Marta Chagas Monteiro, Henri Stephan Schrekker, Pedro Roosevelt Torres Romão, Pedro Roosevelt Torres Romão, Pedro Roosevelt Torres Romão   +20 more
doaj   +1 more source

Brain Involvement in Leishmaniasis. [PDF]

Cell Biochem Funct
ABSTRACT Leishmaniasis is a neglected tropical disease caused by infection with the protozoan parasite Leishmania and it is a significant global health problem. The disease has a wide clinical spectrum, from tegumentary leishmaniasis (TL) that encompasses cutaneous (CL), mucosal (ML) and cutaneous‐diffuse (CDL) forms, to the potentially fatal systemic ...
Freitas CS, Coelho EAF, Christodoulides M.   +2 more
europepmc   +2 more sources