FVB/NJ strain as a mouse model for cutaneous leishmaniasis by Leishmania (L.) amazonensis. [PDF]
Mem Inst Oswaldo CruzLeishmaniases encompass a spectrum of neglected diseases caused by parasites of the genus Leishmania, grouped in two forms: tegumentary and visceral leishmaniasis.In this study, we propose Friend Virus B NIH Jackson (FVB/NJ) mouse strain as a new experimental model of infection with Leishmania (Leishmania) amazonensis, the second most prevalent agent ...
Carrara GMP, Stolf BS.
europepmc +6 more sources
The use of kDNA minicircle subclass relative abundance to differentiate between Leishmania (L.) infantum and Leishmania (L.) amazonensis [PDF]
Parasites & Vectors, 2017 Background Leishmaniasis is a neglected disease caused by many Leishmania species, belonging to subgenera Leishmania (Leishmania) and Leishmania (Viannia).
Marcello Ceccarelli +7 more
doaj +5 more sources
Metacaspase-binding peptide inhibits heat shock-induced death in Leishmania (L.) amazonensis. [PDF]
Cell Death Dis, 2017 AbstractLeishmania (Leishmania) amazonensis is an important agent of cutaneous leishmaniasis in Brazil. This parasite faces cell death in some situations during transmission to the vertebrate host, and this process seems to be dependent on the activity of metacaspase (MCA), an enzyme bearing trypsin-like activity present in protozoans, plants and fungi.
Peña MS +4 more
europepmc +5 more sources
Leishmania (L.) amazonensis LaLRR17 increases parasite entry in macrophage by a mechanism dependent on GRP78. [PDF]
Parasitology, 2023 AbstractLeishmaniases affect 12 million people worldwide. They are caused by Leishmania spp., protozoan parasites transmitted to mammals by female phlebotomine flies. During the life cycle, promastigote forms of the parasite live in the gut of infected sandflies and convert into amastigotes inside the vertebrate macrophages.
Peña MS +10 more
europepmc +4 more sources
Leishmania (L.) amazonensis-induced inhibition of nitric oxide synthesis in host macrophages [PDF]
Microbes and Infection, 2002 Inhibition of lipopolysaccharide (LPS)-induced nitric oxide (NO) production was demonstrated in J774-G8 macrophages infected with Leishmania (L.) amazonensis promastigotes. The downmodulation of NO production observed in infected and LPS-stimulated J774-G8 cells correlated with a reduction in inducible nitric oxide synthase (iNOS) activity.
Filomena M. Perrella Balestieri +5 more
openalex +4 more sources
Tocopherol biosynthesis in Leishmania (L.) amazonensis promastigotes. [PDF]
FEBS Open Bio, 2019 Leishmaniasis is a neglected disease caused by a trypanosomatid protozoan of the genus Leishmania. Most drugs used to treat leishmaniasis are highly toxic, and the emergence of drug‐resistant strains has been observed. Therefore, new therapeutic targets against leishmaniasis are required. Several isoprenoid compounds, including dolichols or ubiquinones,
Balanco JMF +5 more
europepmc +5 more sources
Leishmania (L.) amazonensis infection impairs reproductive and fetal parameters in female mice
Revista Argentina de Microbiología, 2020 Leishmaniasis is a group of parasitic zoonotic diseases caused by intracellular protozoans belonging to the genus Leishmania. Little is known about the effects that this parasitosis may have on the reproductive parameters and pregnancy of infected humans and pets.
María Belén Sánchez +6 more
openalex +4 more sources
Evaluation of Macroalgae Sulfated Polysaccharides on the Leishmania (L.) amazonensis Promastigote [PDF]
Marine Drugs, 2013 The sulfated polysaccharides from Solieria filiformis (Sf), Botryocladia occidentalis (Bo), Caulerpa racemosa (Cr) and Gracilaria caudata (Gc) were extracted and extensively purified. These compounds were then subjected to in vitro assays to evaluate the inhibition of these polysaccharides on the growth of Leishmania (L.) amazonensis promastigotes ...
Camila Lehnhardt Pires +2 more
exaly +5 more sources
Nitro-Heterocyclic compounds induce apoptosis-like effects in Leishmania (L). amazonensis promastigotes. [PDF]
J Venom Anim Toxins Incl Trop Dis, 2019 Three drugs - pentavalent antimonials, amphotericin B and pentamidine - are currently used for leishmaniasis treatment. They are administered for long periods, only parenterally, and have high cardiac, renal and hepatic toxicities. Therefore, the investigation of new compounds is required.
Mendonça DBD +7 more
europepmc +7 more sources
Leishmania amazonensis promastigotes in 3D Collagen I culture: an in vitro physiological environment for the study of extracellular matrix and host cell interactions [PDF]
PeerJ, 2014 Leishmania amazonensis is the causative agent of American cutaneous leishmaniasis, an important neglected tropical disease. Once Leishmania amazonensis is inoculated into the human host, promastigotes are exposed to the extracellular matrix (ECM) of the ...
Debora B. Petropolis +5 more
doaj +5 more sources