Results 1 to 10 of about 8,781 (205)

The use of kDNA minicircle subclass relative abundance to differentiate between Leishmania (L.) infantum and Leishmania (L.) amazonensis [PDF]

Parasites & Vectors, 2017
Background Leishmaniasis is a neglected disease caused by many Leishmania species, belonging to subgenera Leishmania (Leishmania) and Leishmania (Viannia).
Marcello Ceccarelli, Luca Galluzzi, Aurora Diotallevi, Francesca Andreoni, Hailie Fowler, Christine Petersen, Fabrizio Vitale, Mauro Magnani   +7 more
doaj   +7 more sources

Peptides as a Therapeutic Alternative Against Leishmaniasis: A Scoping Review. [PDF]

Chem Biol Drug Des
This scoping review of 79 studies identified 231 antimicrobial peptides with anti‐Leishmania activity, including natural‐derived and synthetic peptides (inspired by natural sources or developed through rational design). Most were evaluated in vitro against promastigote and/or amastigote forms, with synthetic peptides showing a more promising effect ...
da Veiga Oliveira ME, Dyminski Parente Ribeiro E, Guenther OHP, Tomiotto-Pellissier F.   +3 more
europepmc   +2 more sources

Brain Involvement in Leishmaniasis. [PDF]

Cell Biochem Funct
ABSTRACT Leishmaniasis is a neglected tropical disease caused by infection with the protozoan parasite Leishmania and it is a significant global health problem. The disease has a wide clinical spectrum, from tegumentary leishmaniasis (TL) that encompasses cutaneous (CL), mucosal (ML) and cutaneous‐diffuse (CDL) forms, to the potentially fatal systemic ...
Freitas CS, Coelho EAF, Christodoulides M.   +2 more
europepmc   +2 more sources

Surface enolase is a virulence factor of Leishmania amazonensis metacyclic promastigotes involved in adhesion to macrophages [PDF]

Frontiers in Microbiology
We find that enolase, an evolutionarily conserved and multifunctional protein, is displayed on the cell surface of Leishmania amazonensis parasites in a developmentally regulated manner, associated with infectivity.
Franciane dos Santos Alves, Lisvane Paes, Marta Teixeira Gomes, Suzana Passos Chaves, Marcello André Barcinski, José Roberto Meyer-Fernandes, David S. Ucker, João Luiz Mendes Wanderley   +7 more
doaj   +2 more sources

The Regulatory Effect of Histone Deacetylase (HDAC) 1 and 2 on iNOS, IL-6, TNF-α and IL-10 Expression in Canine Macrophages Infected With Leishmania infantum. [PDF]

Parasite Immunol
ABSTRACT Zoonotic visceral leishmaniasis is caused by Leishmania (Leishmania) infantum. Dogs are considered the most critical urban reservoirs of L. (L.) infantum due to their high infection rate and direct transmission to humans. The parasite has developed mechanisms to evade the host's defence system by inhibiting macrophage activation, thereby ...
Venturin GL, Ito LTS, Umino GM, Rebech GT, Lopes FL, de Lima VMF.   +5 more
europepmc   +2 more sources

Imidazolium salts as an alternative for anti-Leishmania drugs: Oxidative and immunomodulatory activities

Frontiers in Immunology, 2023
In this study we explored the previously established leishmanicidal activity of a complementary set of 24 imidazolium salts (IS), 1-hexadecylimidazole (C16Im) and 1-hexadecylpyridinium chloride (C16PyrCl) against Leishmania (Leishmania) amazonensis and ...
Fernanda Giesel Baldissera, Fernanda Giesel Baldissera, Tiago Fazolo, Tiago Fazolo, Matheus Brasil da Silva, Paulo Cesar de Santana Filho, Vinícius Demétrio da Silva, David Max Rivillo Perez, Joice Sandra Klitzke, Eduardo Giovanni de Oliveira Soares, Luiz Carlos Rodrigues Júnior, Luiz Carlos Rodrigues Júnior, Alessandra Peres, Alessandra Peres, Eliane Dallegrave, Kely Campos Navegantes-Lima, Marta Chagas Monteiro, Henri Stephan Schrekker, Pedro Roosevelt Torres Romão, Pedro Roosevelt Torres Romão, Pedro Roosevelt Torres Romão   +20 more
doaj   +1 more source

Innate Resistance to Leishmania amazonensis Infection in Rat Is Dependent on NOS2

Frontiers in Microbiology, 2021
Leishmania infection causes diverse clinical manifestations in humans. The disease outcome is complicated by the combination of many host and parasite factors.
Yun-Fu Chen, Si-Fei Yu, Chang-You Wu, Na Wu, Jia Shen, Juan Shen, Jiang-Mei Gao, Yan-Zi Wen, Geoff Hide, De-Hua Lai, Zhao-Rong Lun, Zhao-Rong Lun   +11 more
doaj   +1 more source

Experimental infection and transmission of Leishmania by Lutzomyia cruzi (Diptera: Psychodidae): Aspects of the ecology of parasite-vector interactions. [PDF]

PLoS Neglected Tropical Diseases, 2017
Several parameters should be addressed before incriminating a vector for Leishmania transmission. Those may include its ability to become infected by the same Leishmania species found in humans, the degree of attractiveness for reservoirs and humans and ...
Everton Falcão de Oliveira, Elisa Teruya Oshiro, Wagner de Souza Fernandes, Paula Guerra Murat, Márcio José de Medeiros, Alda Izabel Souza, Alessandra Gutierrez de Oliveira, Eunice Aparecida Bianchi Galati   +7 more
doaj   +1 more source

In vitro and in vivo Anti-leishmanial Potential of [Ag (PTA) 4 ]BF 4 and [Ag(HBPz 3 )(PPh 3 )] Silver Complexes

Revista da Sociedade Brasileira de Medicina Tropical, 2022
Background: American tegumentary leishmaniasis is a parasitic disease known for being difficult to treat; therefore, the search for more effective therapeutic methods is necessary.
Pauline de Faria Soldera, Ana Flavia da Silva Chagas, Anny Maisa Vargas Brasil, Claudia Dantas Comandolli-Wyrepkowski, Marina Porchia, Antonia Maria Ramos Franco Pereira   +5 more
doaj   +1 more source

DH82 Canine and RAW264.7 Murine Macrophage Cell Lines Display Distinct Activation Profiles Upon Interaction With Leishmania infantum and Leishmania amazonensis

Frontiers in Cellular and Infection Microbiology, 2020
Leishmaniasis is an anthropozoonotic disease, and dogs are considered the main urban reservoir of the parasite. Macrophages, the target cells of Leishmania sp., play an important role during infection.
Natalia Rocha Nadaes, Leandro Silva da Costa, Raissa Couto Santana, Isabel Ferreira LaRocque-de-Freitas, Áislan de Carvalho Vivarini, Deivid Costa Soares, Amanda Brito Wardini, Ulisses Gazos Lopes, Elvira M. Saraiva, Celio Geraldo Freire-de-Lima, Debora Decote-Ricardo, Lucia Helena Pinto-da-Silva   +11 more
doaj   +1 more source