Results 21 to 30 of about 8,781 (205)

Leishmania in synanthropic rodents (Rattus rattus): new evidence for the urbanization of Leishmania (Leishmania) amazonensis [PDF]

Revista Brasileira de Parasitologia Veterinária, 2017
This study aimed to detect parasites from Leishmania genus, to determine the prevalence of anti-Leishmania spp. antibodies, to identify circulating species of the parasite, and to determine epidemiological variables associated with infection in rats ...
Eloiza Teles Caldart, Roberta Lemos Freire, Fernanda Pinto Ferreira, Bruno Bergamo Ruffolo, Mônica Raquel Sbeghen, Marcelle Mareze, João Luis Garcia, Regina Mitsuka-Breganó, Italmar Teodorico Navarro   +8 more
doaj   +3 more sources

Tocopherol biosynthesis in Leishmania (L.) amazonensis promastigotes. [PDF]

FEBS Open Bio, 2019
Leishmaniasis is a neglected disease caused by a trypanosomatid protozoan of the genus Leishmania. Most drugs used to treat leishmaniasis are highly toxic, and the emergence of drug‐resistant strains has been observed. Therefore, new therapeutic targets against leishmaniasis are required. Several isoprenoid compounds, including dolichols or ubiquinones,
Balanco JMF, Sussmann RAC, Verdaguer IB, Gabriel HB, Kimura EA, Katzin AM.   +5 more
europepmc   +5 more sources

Nitro-Heterocyclic compounds induce apoptosis-like effects in Leishmania (L). amazonensis promastigotes. [PDF]

J Venom Anim Toxins Incl Trop Dis, 2019
Three drugs - pentavalent antimonials, amphotericin B and pentamidine - are currently used for leishmaniasis treatment. They are administered for long periods, only parenterally, and have high cardiac, renal and hepatic toxicities. Therefore, the investigation of new compounds is required.
Mendonça DBD, Silva REC, Palace-Berl F, Takakura CF, Soares SRC, Braz LMA, Tavares LC, Lindoso JAL.   +7 more
europepmc   +7 more sources

FVB/NJ strain as a mouse model for cutaneous leishmaniasis by Leishmania (L.) amazonensis. [PDF]

Mem Inst Oswaldo Cruz
Leishmaniases encompass a spectrum of neglected diseases caused by parasites of the genus Leishmania, grouped in two forms: tegumentary and visceral leishmaniasis.In this study, we propose Friend Virus B NIH Jackson (FVB/NJ) mouse strain as a new experimental model of infection with Leishmania (Leishmania) amazonensis, the second most prevalent agent ...
Carrara GMP, Stolf BS.
europepmc   +4 more sources

Role of Leishmania (Leishmania) amazonensis amastigote glycosphingolipids in macrophage infectivity

Brazilian Journal of Medical and Biological Research, 2007
The role of glycosphingolipids (GSLs) present in amastigote forms of Leishmania (Leishmania) amazonensis during infection of macrophages was analyzed, with particular emphasis on GSLs presenting the terminal Galpß1-3Galpa disaccharide.
A.K. Tanaka, P.A.J. Gorin, H.K. Takahashi, A.H. Straus   +3 more
doaj   +3 more sources

Py-CoMFA, docking, and molecular dynamics simulations of Leishmania (L.) amazonensis arginase inhibitors. [PDF]

Sci Rep
AbstractLeishmaniasis is a disease caused by a protozoan of the genus Leishmania, affecting millions of people, mainly in tropical countries, due to poor social conditions and low economic development. First-line chemotherapeutic agents involve highly toxic pentavalent antimonials, while treatment failure is mainly due to the emergence of drug ...
Camargo PG, Dos Santos CR, Girão Albuquerque M, Rangel Rodrigues C, Lima CHDS.   +4 more
europepmc   +4 more sources

Leishmania (L.) amazonensis infection impairs reproductive and fetal parameters in female mice

Revista Argentina de Microbiología, 2021
Leishmaniasis is a group of parasitic zoonotic diseases caused by intracellular protozoans belonging to the genus Leishmania. Little is known about the effects that this parasitosis may have on the reproductive parameters and pregnancy of infected humans and pets.
Sánchez, María Belén, Germano, Maria Jose, Salomón, María Cristina, Scelta, Julieta, Garcia Bustos, Maria Fernanda, Ginevro, Paula María, Cargnelutti, Diego Esteban   +6 more
openaire   +3 more sources

Metacaspase-binding peptide inhibits heat shock-induced death in Leishmania (L.) amazonensis. [PDF]

Cell Death Dis, 2017
AbstractLeishmania (Leishmania) amazonensis is an important agent of cutaneous leishmaniasis in Brazil. This parasite faces cell death in some situations during transmission to the vertebrate host, and this process seems to be dependent on the activity of metacaspase (MCA), an enzyme bearing trypsin-like activity present in protozoans, plants and fungi.
Peña MS, Cabral GC, Fotoran WL, Perez KR, Stolf BS.   +4 more
europepmc   +4 more sources

The Expression of Mannose Receptors in Skin Fibroblast and Their Involvement in Leishmania (L.) amazonensis Invasion [PDF]

Journal of Histochemistry & Cytochemistry, 2005
Leishmania are protozoa that invade mononuclear phagocytes with the involvement of different ligand-receptor systems, including mannose receptors. Until now, scant data are available concerning the mechanisms that govern the infection of Leishmania in other host cell types such as fibroblasts.
Renata C, Hespanhol, Maria, de Nazaré C Soeiro, Marcos B, Meuser, Maria, de Nazareth S L Meirelles, Suzana, Côrte-Real   +4 more
openaire   +3 more sources

Immucillins Impair Leishmania (L.) infantum chagasi and Leishmania (L.) amazonensis Multiplication In Vitro

PLOS ONE, 2015
Chemotherapy against visceral leishmaniasis is associated with high toxicity and drug resistance. Leishmania parasites are purine auxotrophs that obtain their purines from exogenous sources. Nucleoside hydrolases release purines from nucleosides and are drug targets for anti-leishmanial drugs, absent in mammal cells.
Elisangela Oliveira Freitas, Dirlei Nico, Rong Guan, José Roberto Meyer-Fernandes, Keith Clinch, Gary B Evans, Peter C Tyler, Vern L Schramm, Clarisa B Palatnik-de-Sousa   +8 more
openaire   +4 more sources