Results 21 to 30 of about 14,096,336 (162)

Murine T Cell-Dependent Response Affects Leishmania amazonensis Amastigote Survival and Virulence. [PDF]

Cell Biol Int
ABSTRACT Our group has previously described the infection course of Leishmania amazonensis in BALB/c and BALB/cnu/nu mice, which have distinct T‐cell dependent responses. In this study, lesion‐derived amastigotes exhibited differential protein expression in a host‐dependent manner.
Soares GHC, Barbosa GR, Stolf BS.
europepmc   +2 more sources

Dicentrine, an Aporphine Alkaloid From Ocotea langsdorffii, Induces Mitochondrial Dysfunction and Oxidative Stress in Leishmania (L.) infantum. [PDF]

Chem Biodivers
Dicentrine, an aporphine alkaloid, exhibits potent in vitro antileishmanial activity against Leishmania species with high selectivity and low macrophage cytotoxicity. Mechanistic studies reveal that the compound triggers parasite death possibly by inducing mitochondrial membrane disruption and oxidative stress.
de Freitas CS, da Silva EOS, Tristão DC, Antar GM, Lage DP, Abrão DM, Antinarelli LMR, Coimbra ES, Lago JHG, Coelho EAF.   +9 more
europepmc   +2 more sources

Pyridyl-Thiazole-Thiosemicarbazones as Antitrypanosomatidae Agents: Design, Synthesis, and In Silico Profiling. [PDF]

ChemMedChem
A novel pyridine–thiazole derivative, Compound 8, exhibited potent dual antitrypanosomatid activity. It demonstrated remarkable in vitro efficacy against Trypanosoma cruzi (IC50 = 1.0 µM) and L. amazonensis (IC50 = 3.9 µM). Molecular docking studies suggested interactions with heme and multiple molecular targets.
Silva AJFSD, Olimpio DSDC, Sousa LMDS, Brondani GL, Silva TL, Silva WBL, Costa NTC, Hernandes MZ, Junior PAS, Pereira VRA, Leite ACL.   +10 more
europepmc   +2 more sources

Leukocyte Behavior in Mesenteric Microcirculation upon Experimental By Leishmania Spp. in BALB/c Mice

Iranian Journal of Parasitology, 2021
Background: We aimed to determine the cellular recruitment (leukocyte rolling and adhesion) by which the Leishmania (Viannia) braziliensis, L. (Leishmania) amazonensis, and L. (Leishmania) major species in the mesenteric microcirculation of BALB/c mice.
Herintha Coeto Neitzke-Abreu, Rhuan Carlos Souza Caetano, Kárin Rosi Reinhold-Castro, Manoel Sebastião da Costa Lima-Junior, Wagner José Tenório dos Santos, Gessilda de Alcantara Nogueira de Melo, Roberto Kenji Nakamura Cuman, Sandra Mara Alessi Aristides, Thais Gomes Verzignassi Silveira, Maria Valdrinez Campana Lonardoni   +9 more
doaj  

Immune responses induced by a Leishmania (Leishmania) amazonensis recombinant antigen in mice and lymphocytes from vaccinated subjects

Revista do Instituto de Medicina Tropical de São Paulo, 1997
In the search for Leishmania recombinant antigens that can be used as a vaccine against American Cutaneous Leishmaniasis, we identified a Leishmania (Leishmania) amazonensis recombinant protein of 33 kD (Larp33) which is recognized by antibodies and ...
Ana Paula FERNANDES, Elizabeth Cortez HERRERA, Wilson MAYRINK, Ricardo T. GAZZINELLI, Wen Yu LIU, Carlos Alberto da COSTA, Carlos Alberto Pereira TAVARES, Maria Norma MELO, Marilene Susan Marques MICHALICK, Reiner GENTZ, Evaldo NASCIMENTO   +10 more
doaj   +1 more source

In vitro leishmanicidal effect of Yangambin and Epi-yangambin lignans isolated from Ocotea fasciculata (Nees) Mez

Frontiers in Cellular and Infection Microbiology, 2023
IntroductionYangambin and epi-yangambin are the main lignans found in Louro-de-Cheiro [Ocotea fasciculata (Nees) Mez], a tree native to the Atlantic forests of northeastern Brazil whose leaves and bark are widely used in folk medicine.
Jéssica Rebouças-Silva, Jéssica Rebouças-Silva, Gabriel Farias Santos, José Maria Barbosa Filho, Andresa A. Berretta, Franciane Marquele-Oliveira, Valéria M. Borges, Valéria M. Borges   +7 more
doaj   +1 more source

Leishmania amazonensis promastigotes in 3D Collagen I culture: an in vitro physiological environment for the study of extracellular matrix and host cell interactions [PDF]

PeerJ, 2014
Leishmania amazonensis is the causative agent of American cutaneous leishmaniasis, an important neglected tropical disease. Once Leishmania amazonensis is inoculated into the human host, promastigotes are exposed to the extracellular matrix (ECM) of the ...
Debora B. Petropolis, Juliany C.F. Rodrigues, Nathan B. Viana, Bruno Pontes, Camila F.A. Pereira, Fernando C. Silva-Filho   +5 more
doaj   +2 more sources

The Paradox of a Phagosomal Lifestyle: How Innate Host Cell-Leishmania amazonensis Interactions Lead to a Progressive Chronic Disease

Frontiers in Immunology, 2021
Intracellular phagosomal pathogens represent a formidable challenge for innate immune cells, as, paradoxically, these phagocytic cells can act as both host cells that support pathogen replication and, when properly activated, are the critical cells that ...
Matheus B. Carneiro, Nathan C. Peters
doaj   +1 more source

Axenic cultivation and characterization of Leishmania mexicana amastigote-like forms [PDF]

, 1992
A new method is described which has made possible the long-term axenic cultivation of Leishmania mexicana amastigote-like forms in Schneider's Drosophila medium supplemented with 20% (v/v) foetal calf serum.
Coombs, G H, Robertson, C D, Tetley, L, Bates, P A   +3 more
core   +5 more sources

Leishmania isoenzyme polymorphisms in Ecuador: Relationships with geographic distribution and clinical presentation [PDF]

, 2006
Background: Determinants of the clinical presentation of the leishmaniases are poorly understood but Leishmania species and strain differences are important.
Cooper Philip J, Masataka Korenaga, Marco Jorge D, Korenaga, Masataka, Rodrigo X Armijos, Hirotomo Kato, Paola A Barroso, Kato Hirotomo, Korenaga, M, Gomez, EA, Calvopina Manuel, Kato, Hirotomo, Hiroshi Uezato, Barroso, Paola A., Armijos, Rodrigo X., Cooper, PJ, Yoshihisa Hashiguchi, Shigeo Nonaka, Nonaka Shigeo, Gomez Eduardo A, Manuel Calvopina, Marco, Jorge D., Kato, H, Barroso Paola A, Mimori, Tatsuyuki, Armijos, RX, Hashiguchi, Y, Nonaka, Shigeo, Eduardo A Gomez, Calvopina, M, Marco, JD, Korenaga Masataka, Tatsuyuki Mimori, Uezato, H, Jorge D Marco, Gomez, Eduardo A., Calvopina, Manuel, Mimori Tatsuyuki, Manuel Calvopina, Uezato Hiroshi, Cooper, Philip J., Hashiguchi, Yoshihisa, Mimori, T, Philip J Cooper, Nonaka, S, Uezato, Hiroshi, Armijos Rodrigo X, Barroso, PA, Hashiguchi Yoshihisa   +48 more
core   +2 more sources