Results 101 to 110 of about 8,781 (205)

Immunity to Leishmania mexicana parasite

, 2014
Background: Cutaneous Leishmaniasis caused by the Leishmania mexicana complex is associated with unpleasant or disfiguring lesions, for which there only limited treatment options. The life cycle of L.
Ali, KSM
core  

Characterization of skeletal muscle cell infection by Leishmania (L.) amazonensis.

, 2016
A leishmaniose é um grupo de doenças causadas por parasitos do gênero Leishmania com três manifestações clínicas principais: cutânea, mucocutânea e visceral. No Brasil, a leishmaniose é um importante problema de saúde pública pela alta incidência.
Arango, Natalia Fiesco
core   +1 more source

Studies on immunology of Leishmania mexicana

, 2007
Leishmaniasis is a worldwide disease prevalent in many tropical and sub tropical countries. Treatment of Leishmaniasis by chemotherapy is not wholly effective and is usually accompanied by unpleasant side effects.
Rezvan, H, Rezvan, Hossein
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Effects of a Serine Protease Inhibitor N-p-Tosyl-L-phenylalanine Chloromethyl Ketone (TPCK) on Leishmania amazonensis and Leishmania infantum

, 2022
Studies have previously demonstrated the importance of serine proteases in Leishmania. A well-known serine protease inhibitor, TPCK, was used in the present study to evaluate its in vitro and in vivo antileishmanial effects and determine its mechanism of
Machado, Patrícia de A., Midlej, Victor, Pollyanna S. Gomes, Patrícia de A. Machado, Monique P. D. Carneiro, Coimbra, Elaine S., de Matos Guedes, Herbert L., Elaine S. Coimbra, Herbert L. de Matos Guedes, Gomes, Pollyanna S., Victor Midlej, Carneiro, Monique P. D.   +11 more
core   +1 more source

Anti-leishmanial Activity of Justicidone and its Synthetic Precursors

Natural Product Communications, 2007
Justicidone, a C-5, C-8 dioxo-lignan of the arylnaphthalene type isolated from Justicia hyssopifolia, and its synthetic precursors were tested for the activity against Leishmania braziliensis and Leishmania amazonensis promastigotes in vitro. Justicidone
Carlos José Boluda, José Piñero, Marialina Romero, María Gabriela Cabrera-Serra, Basilio Valladares, Zulma Aragón, Hermelo López, José A. Pérez, Juan M. Trujillo   +8 more
doaj   +1 more source

Glutathione and the redox control system trypanothione/trypanothione reductase are involved in the protection of Leishmania spp. against nitrosothiol-induced cytotoxicity

Brazilian Journal of Medical and Biological Research, 2006
Glutathione is the major intracellular antioxidant thiol protecting mammalian cells against oxidative stress induced by oxygen- and nitrogen-derived reactive species.
P.R.T. Romão, J. Tovar, S.G. Fonseca, R.H. Moraes, A.K. Cruz, J.S. Hothersall, A.A. Noronha-Dutra, S.H. Ferreira, F.Q. Cunha   +8 more
doaj   +1 more source

Benzophenone derivatives as cysteine protease inhibitors and biological activity against Leishmania(L.) amazonensis amastigotes

Biomedicine & Pharmacotherapy, 2015
The leishmanicidal potential of benzophenones has been described, some of them highlighting their potential as cysteine protease inhibitors. Therefore, this work described leishmanicidal activity of nine benzophenone derivatives (1a-c;2a-c;3a-c) against intramacrophage amastigote forms of Leishmania(L.)amazonensis (IC50) and the cytotoxic effect on ...
Letícia, de Almeida, Karina Ferreira, Alves, Claudia Mara, Maciel-Rezende, Larissa de Oliveira Passos, Jesus, Francieli Ribeiro, Pires, Claudio Viegas, Junior, Mario Augusto, Izidoro, Wagner Alves de Souza, Júdice, Marcelo Henrique, dos Santos, Marcos José, Marques   +9 more
openaire   +2 more sources

Avaliação da atividade tripanocida e leishmanicida de produtos naturais da flora mato-grossense [PDF]

, 2008
TCC(graduação) - Universidade Federal de Santa Catarina. Centro de Ciências Biológicas. Biologia.O arsenal quimioterápico disponível para o tratamento da Doença de Chagas e das Leishmanioses é restrito a poucos fármacos, os quais apresentam eficácia ...
Nunes, Rebeca Körting
core  

Activity of anti-cancer protein kinase inhibitors against Leishmania spp.

, 2014
OBJECTIVES: There is an urgent need to develop new and effective treatments for poverty-related neglected diseases. In light of the time required to bring a new drug to market and the cost involved (10-15 years, >1 billion US$), one approach to ...
Croft, Simon L, Sanderson, Lisa, Yardley, Vanessa   +2 more
core   +1 more source

Embryos extract from germinated yellow soybean (Glycine max [L.] Merrill) inhibits promastigotes form of Leishmania amazonensis [PDF]

Brazilian Journal of Biology
We investigated the effect of extracts of the germinated seeds of yellow soybean cultivar BRS 258 (Glycine max [L.] Merrill) against Leishmania amazonensis promastigotes. The yellow soybean embryos extract (YSEE) was fractionated on a Sephacryl S-100 gel
P. M. Pedrote, D. M. D. Bouts, C. L. A. Passos, J. D. Inácio, L.F.O. Gervazoni, R. Zingali, M. S. Almeida, K. M. S. Cabral, C. Follmer, E. E. Almeida-Amaral, E. Fialho   +10 more
doaj   +1 more source