Results 111 to 120 of about 8,781 (205)

Synthetic glycovaccine protects against the bite of leishmania-infected sand flies

, 2006
Leishmaniasis is a vectorborne disease transmitted to human and other mammalian hosts by sand fly bite. In the present study, we show that immunization with Leishmania mexicana promastigote secretory gel (PSG) or with a chemically defined synthetic ...
Bates, Paul A., Nikolaev, Andrei V., Ferguson, Michael AJ, Ferguson, Michael A. J.; id_orcid, Sizova, O. V., Ferguson, M. A. J., Rogers, Matthew E., Ferguson, Michael A J, Rogers, Matthew E, Bates, Paul, Sizova, Olga V, Nikolaev, Andrei V, Bates, Paul A, Sizova, Olga V., Nikolaev, A. V.   +14 more
core   +1 more source

High dilutions of antimony modulate cytokines production and macrophage – Leishmania (L.) amazonensis interaction in vitro

Cytokine, 2017
In previous results mice treated with high dilutions of antimony presented reduction of monocyte migration to the site of infection with increase in B lymphocytes population in the local lymph node.To know the mechanisms involved, a series of in vitro studies was done, using co-cultures of macrophages (RAW 264.7) and Leishmania (L.) amazonensis treated
Fabiana Rodrigues, de Santana, Luciane C, Dalboni, Kátia F, Nascimento, Fabiana Toshie, Konno, Anuska M, Alvares-Saraiva, Michelle S F, Correia, Maristela Dutra Correa, Bomfim, Renato C V, Casarin, Elizabeth C, Perez, Maria Anete, Lallo, Giovani B, Peres, Márcia Dalastra, Laurenti, Nilson R, Benites, Dorly F, Buchi, Leoni Villano, Bonamin   +14 more
openaire   +2 more sources

Extracellular Vesicles Released by Leishmania (Leishmania) amazonensis Promote Disease Progression and Induce the Production of Different Cytokines in Macrophages and B-1 Cells

Frontiers in Microbiology, 2018
The extracellular vesicles (EVs) released by Leishmania can contribute to the establishment of infection and host immunomodulation. In this study, we characterized the shedding of EVs from Leishmania (Leishmania) amazonensis promastigotes.
Fernanda Marins Costa Barbosa, Talita Vieira Dupin, Mayte dos Santos Toledo, Natasha Ferraz dos Campos Reis, Kleber Ribeiro, André Cronemberger-Andrade, Jeronimo Nunes Rugani, Beatriz Helena Pizarro De Lorenzo, Ronni Rômulo Novaes e Brito, Rodrigo Pedro Soares, Ana Claudia Torrecilhas, Patricia Xander   +11 more
doaj   +1 more source

Characterization of Leishmania (L.) amazonensis oligopeptidase B and its role in macrophage infection. [PDF]

Parasitology, 2022
Barbosa GR, Marana SR, Stolf BS.
europepmc   +1 more source

Coinfection of mice with Icoaraci exacerbates the infection of Leishmania (L.) amazonensis.

, 2019
(A) Wild-type C57BL/6 mice were infected with stationary-phase promastigotes of L. (L.) amazonensis at a ratio of 5 x 106, 2,25 x 105 PFU of Icoaraci virus, or coinfected.
Marcia Dalastra Laurenti (6857870), Renata Meirelles Santos Pereira (313955), Clarissa R. Damaso (2226481), Pedro Fernando da Costa Vasconcelos (87694), Claudia Gomes (6857867), Carolina Torturella Rath (6857861), Laila Castro Schnellrath (6857864), Nicolas Fasel (209333), Luciana Barros de Arruda (37086), Áislan de Carvalho Vivarini (6857876), Ulisses Gazos Lopes (313957), Teresa Cristina Calegari Silva (6857873)   +11 more
core   +1 more source

L-arginine availability and arginase activity: Characterization of amino acid permease 3 in Leishmania amazonensis

PLOS Neglected Tropical Diseases, 2017
Leishmania uses the amino acid L-arginine as a substrate for arginase, enzyme that produces urea and ornithine, last precursor of polyamine pathway. This pathway is used by the parasite to replicate and it is essential to establish the infection in the mammalian host. L-arginine is not synthesized by the parasite, so its uptake occurs through the amino
Juliana Ide Aoki, Sandra Marcia Muxel, Ricardo Andrade Zampieri, Stephanie Maia Acuña, Juliane Cristina Ribeiro Fernandes, Rubia Heloisa Vanderlinde, Maria Carmen Oliveira de Pinho Sales, Lucile Maria Floeter-Winter   +7 more
openaire   +4 more sources

Investigating the role of the Leishmania (Leishmania) major HASP and SHERP genes during metacyclogenesis in the sand fly vectors, Phlebotomus (Phlebotomus) papatasi and Ph. (Ph.) duboscqi [PDF]

, 2013
Leishmania parasites are the causative agents of a diverse spectrum of infectious diseases termed the leishmaniases. These digenetic parasites exist as intracellular, aflagellate amastigotes in a mammalian host and as extracellular flagellated ...
Doehl, Johannes
core  

Cross-protective effect of a combined L5 plus L3 Leishmania major ribosomal protein based vaccine combined with a Th1 adjuvant in murine cutaneous and visceral leishmaniasis

Parasites & Vectors, 2014
Background Two Leishmania major ribosomal proteins L3 (LmL3) and L5 (LmL5) have been described as protective molecules against cutaneous leishmaniasis due to infection with L.
Laura Ramirez, Laura Corvo, Mariana C Duarte, Miguel A Chávez-Fumagalli, Diogo G Valadares, Diego M Santos, Camila I de Oliveira, Marta R Escutia, Carlos Alonso, Pedro Bonay, Carlos AP Tavares, Eduardo AF Coelho, Manuel Soto   +12 more
doaj   +1 more source

Assessment of PCR in the detection of Leishmania spp in experimentally infected individual phlebotomine sandflies (Diptera: Psychodidae: Phlebotominae)

Revista do Instituto de Medicina Tropical de São Paulo, 2002
DNA amplification by the polymerase chain reaction (PCR) was applied in the investigation of the presence of Leishmania (Kinetoplastida: Trypanosomatidae) parasites in single phlebotomine sandflies.
MICHALSKY Érika M., FORTES-DIAS Consuelo L., PIMENTA Paulo F.P., SECUNDINO Nágila F.C., DIAS Edelberto S.   +4 more
doaj  

Comparative study of the ability of Leishmania mexicana promastigotes and amastigotes to alter macrophage signalling and functions

, 2010
Leishmania alternates between two morphologically different stages: promastigotes and amastigotes. While the majority of reports focused on how the promastigote form can alter macrophage signalling and function, fewer reports investigated signalling ...
Hassani, K., Westra, E.R., Abu-Dayyeh, I., Edze R. Westra, Kasra Hassani, Issa Abu-Dayyeh, Mottram, J.C., Olivier, M., Jeremy C. Mottram, Martin Olivier   +9 more
core   +1 more source