Results 21 to 30 of about 885 (162)

In Vitro Susceptibility to Miltefosine of Leishmania infantum (syn. L. chagasi) Isolates from Different Geographical Areas in Brazil [PDF]

Microorganisms, 2021
Treatment of visceral leishmaniasis in Brazil still relies on meglumine antimoniate, with less than ideal efficacy and safety, making new therapeutic tools an urgent need. The oral drug miltefosine was assayed in a phase II clinical trial in Brazil with cure rates lower than previously demonstrated in India.
Caroline Ricce Espada, Erica V. de Castro Levatti, Mariana Côrtes Boité, Dorcas Lamounier, Jorge Alvar, Elisa Cupolillo, Carlos Henrique Nery Costa, Joelle Rode, Silvia R. B. Uliana   +8 more
openaire   +3 more sources

Evolutionary and geographical history of the Leishmania donovani complex with a revision of current taxonomy. [PDF]

, 2007
Leishmaniasis is a geographically widespread severe disease, with an increasing incidence of two million cases per year and 350 million people from 88 countries at risk. The causative agents are species of Leishmania, a protozoan flagellate.
Soteriadou, Ketty, Tintaya, K Wilber Quispe, Oborník, Miroslav, Lukes, Julius, Ayala, Francisco J, Kuhls, Katrin, Dujardin, Jean-Claude, Mauricio, Isabel L, Jirků, Milan, Pratlong, Francine, Miles, Michael A, Chocholová, Eva, Haralambous, Christos, Dedet, Jean-Pierre, Horák, Ales, Schönian, Gabriele   +15 more
core   +1 more source

LXR deficiency confers increased protection against visceral Leishmania infection in mice. [PDF]

PLoS Neglected Tropical Diseases, 2010
The liver X receptors (LXRs) are a family of nuclear receptor transcription factors that are activated by oxysterols and have defined roles in both lipid metabolism and cholesterol regulation.
Kevin W Bruhn, Chaitra Marathe, Ana Cláudia Maretti-Mira, Hong Nguyen, Jacquelyn Haskell, Thu Anh Tran, Veena Vanchinathan, Upasna Gaur, Mary E Wilson, Peter Tontonoz, Noah Craft   +10 more
doaj   +1 more source

Macrophage Polarization in the Skin Lesion Caused by Neotropical Species of Leishmania sp

Journal of Immunology Research, 2021
Macrophages play important roles in the innate and acquired immune responses against Leishmania parasites. Depending on the subset and activation status, macrophages may eliminate intracellular parasites; however, these host cells also can offer a safe ...
Carmen M. Sandoval Pacheco, Gabriela V. Araujo Flores, Kadir Gonzalez, Claudia M. de Castro Gomes, Luiz F. D. Passero, Thaise Y. Tomokane, Wilfredo Sosa-Ochoa, Concepción Zúniga, Jose Calzada, Azael Saldaña, Carlos E. P. Corbett, Fernando T. Silveira, Marcia D. Laurenti   +12 more
doaj   +1 more source

Heterogeneities in leishmania infantum infection : using skin parasite burdens to identify highly infectious dogs [PDF]

, 2013
Background: The relationships between heterogeneities in host infection and infectiousness (transmission to arthropod vectors) can provide important insights for disease management.
Quinnell, Rupert J., Leo Calvo-Bado (507757), Orin Courtenay (103643), Lourdes M. Garcez (103639), Rupert J Quinnell, Calvo-Bado, L, Rupert J. Quinnell, Quinnell Rupert J., Courtenay, Orin, Connor Carson, Garcez Lourdes M., Calvo-Bado, Leo A., Leo Calvo-Bado, Garcez, LM, Connor Carson (103631), Courtenay, O, Calvo-Bado Leo, Rupert J. Quinnell (103626), Quinnell, RJ, Garcez, Lourdes M., Carson, Connor, Lourdes M Garcez, Orin Courtenay, Courtenay Orin, Carson Connor, Carson, C, Lourdes M. Garcez   +26 more
core   +1 more source

Macrophage and T-cell gene expression in a model of early infection with the protozoan Leishmania chagasi. [PDF]

PLoS Neglected Tropical Diseases, 2008
Visceral leishmaniasis is a potentially fatal infectious disease caused by the protozoan parasite Leishmania infantum/chagasi in the New World, or by L. donovani or L. infantum/chagasi in the Old World.
Nicholas A Ettinger, Mary E Wilson
doaj   +1 more source

A real-time PCR assay to estimate Leishmania chagasi load in its natural sand fly vector Lutzomyia longipalpis [PDF]

, 2008
Leishmania chagasi, transmitted mainly by Lutzomyia longipalpis sand flies, causes visceral leishmaniasis and atypical cutaneous leishmaniasis in Latin America.
Bates, Paul A., Maingon, Rhayza D.C., Ranasinghe, Shalindra, Ranasinghe, S., Rogers, Matthew E., Hamilton, J. G. C., Maingon, Rhayza DC, Rogers, Matthew E, Bates, Paul, Hamilton, James G C, Maingon, Rhayza D C, Hamilton, James GC, Maingon, R. D. C., Hamilton, James G.C., Bates, Paul A   +14 more
core   +1 more source

The transmission of Leishmania infantum chagasi by the bite of the Lutzomyia longipalpis to two different vertebrates

Parasites & Vectors, 2012
Background Sandflies are vectors of Leishmania, the causative agent of leishmaniasis in mammalian hosts, including humans. The protozoan parasite is transmitted by the sandfly bite during salivation that occurs at the moment of blood feeding.
Secundino Nagila FC, de Freitas Vanessa C, Monteiro Carolina C, Pires Ana-Clara AM, David Bruna A, Pimenta Paulo FP   +5 more
doaj   +1 more source

Leishmania donovani is the only cause of visceral leishmaniasis in East Africa; previous descriptions of L. infantum and "L. archibaldi" from this region are a consequence of convergent evolution in the isoenzyme data [PDF]

, 2004
Isoenzyme-based studies have identified 3 taxa/species/'phylogenetic complexes' as agents of visceral leishmaniasis in Sudan: L. donovani, L. infantum and "L. archibaldi". However, these observations remain controversial.
Watts, P C, Ashford, R.W., Noyes, H A, Kemp, S J, Jamjoom, M B, Kemp, S. J., Noyes, H. A., Bates, P A, Chance, M L, Jamjoom, M.B., Watts, P. C., Bates, Paul, Chance, Michael, Ashford, R W   +13 more
core   +1 more source

Feline leishmaniosis due to Leishmania infantum (syn. L. chagasi)

Journal of the Hellenic Veterinary Medical Society, 2018
From the beginning of the 20th century, feline infections by at least eight different Leishmania species have been sporadically reported, worldwide. In the Mediterranean countries, feline infection imposed by L. infantum, the aetiological agent of canine leishmaniosis and human visceral and cutaneous leishmaniasis, is of particular importance, because ...
M CHATZIS, MN SARIDOMICHELAKIS, AF KOUTINAS   +2 more
openaire   +2 more sources