Results 11 to 20 of about 2,247 (156)

Preclinical diagnosis of American visceral leishmaniasis during early onset of human Leishmania (L.) infantum chagasi-infection [PDF]

Pathogens and Global Health, 2014
American visceral leishmaniasis (AVL) is an infectious disease, often with long-duration evolution, caused by Leishmania (L.) infantum chagasi. However, although the disease is considered the major clinical manifestation of the link between L. (L.) i.
Thiago Vasconcelos Dos Santos, Fernando T. Silveira, Marcia Dalastra Laurenti   +2 more
exaly   +5 more sources

Cortisol Regulates PD-1 and IL-12 in Canine Leishmaniasis. [PDF]

Parasite Immunol
ABSTRACT Canine visceral leishmaniasis (CanL) is a tropical zoonosis caused by Brazil's protozoan Leishmania (L.) infantum. Disorders in the hypothalamic–pituitary–adrenal (HPA) axis have been reported in human and experimental visceral leishmaniasis, but not yet in canine leishmaniasis.
Ito LTS, Umino GM, Guimarães MA, de Souza BMM, Soares SF, Pereira LEAL, de Lima VMF.   +6 more
europepmc   +2 more sources

Vaccination with L. infantum chagasi nucleosomal histones confers protection against new world cutaneous leishmaniasis caused by Leishmania braziliensis.

PLoS ONE, 2012
BackgroundNucleosomal histones are intracellular proteins that are highly conserved among Leishmania species. After parasite destruction or spontaneous lysis, exposure to these proteins elicits a strong host immune response.
Marcia W Carneiro, Diego M Santos, Kiyoshi F Fukutani, Jorge Clarencio, Jose Carlos Miranda, Claudia Brodskyn, Aldina Barral, Manoel Barral-Netto, Manuel Soto, Camila I de Oliveira   +9 more
doaj   +4 more sources

In situ cellular immune response in non-ulcerated skin lesions due to Leishmania (L.) infantum chagasi infection. [PDF]

J Venom Anim Toxins Incl Trop Dis, 2021
Background Skin lesions of patients affected by non-ulcerated cutaneous leishmaniasis (NUCL) caused by L. (L.) infantum chagasi are characterized by lymphohistiocytic inflammatory infiltrate associated with epithelioid granuloma and scarce parasitism. However, the in situ cellular immune response of these patients is unclear. Therefore, the aim of the
Sandoval C, Araujo G, Sosa W, Avalos S, Silveira F, Corbett C, Zúniga C, Laurenti M.   +7 more
europepmc   +5 more sources

Can domestic dogs be considered a good reservoir of Leishmania (L.) infantum chagasi in an endemic area of nonulcerated cutaneous leishmaniasis in Southern Honduras? [PDF]

Rev Inst Med Trop Sao Paulo, 2023
Dogs are considered to be the main domestic reservoir associated with the transmission of Leishmania (L.) infantum chagasi to humans in endemic areas of visceral leishmaniasis in America. However, little is known about the role of canines as a source of infection in endemic areas of nonulcerated cutaneous leishmaniasis (NUCL).
Segura GBR, Ochoa WHS, Matta VLRD, Martínez M, Tercero CR, Gonzalez RR, Pacheco CMS, Flores GVA, Silveira FT, Henriquez MMR, Laurenti MD.   +10 more
europepmc   +4 more sources

Further evidence associating IgG1, but not IgG2, with susceptibility to canine visceral leishmaniasis caused by Leishmania (L.) infantum chagasi-infection. [PDF]

Parasite, 2017
We present here a cross-sectional study analyzing the IgG1 and IgG2 immune responses to natural canine Leishmania (L.) infantum chagasi-infection and their relationships with delayed-type hypersensitivity (DTH) in 50 mongrel dogs with previous positive serodiagnoses (IFAT-IgG) (56% with subclinical status [= apparently healthy] and 44% clinically sick),
Lima LVDR, Carneiro LA, Campos MB, Vasconcelos Dos Santos T, Ramos PK, Laurenti MD, Teixeira CEC, Silveira FT.   +7 more
europepmc   +6 more sources

Unusual Clinical Manifestations of Leishmania (L.) infantum chagasi in an HIV-coinfected Patient and the Relevance of ITS1-PCR-RFLP: A Case Report

Iranian Journal of Parasitology, 2018
Patients coinfected with Leishmania/HIV can develop atypical forms of visceral leishmaniasis (VL), making it indispensable to identify the etiological agent. We are presenting a postmortemspecie definition by ITS1-PCR-RFLP in a larynx tissue of a patient
De Godoy NATALIA SOUZA DE, Aiello VERA DEMARCHI, de Souza REGINA MAIA, Okay THELMA, Braz LUCIA MARIA ALMEIDA   +4 more
doaj   +2 more sources

Imidazolium salts as an alternative for anti-Leishmania drugs: Oxidative and immunomodulatory activities

Frontiers in Immunology, 2023
In this study we explored the previously established leishmanicidal activity of a complementary set of 24 imidazolium salts (IS), 1-hexadecylimidazole (C16Im) and 1-hexadecylpyridinium chloride (C16PyrCl) against Leishmania (Leishmania) amazonensis and ...
Fernanda Giesel Baldissera, Fernanda Giesel Baldissera, Tiago Fazolo, Tiago Fazolo, Matheus Brasil da Silva, Paulo Cesar de Santana Filho, Vinícius Demétrio da Silva, David Max Rivillo Perez, Joice Sandra Klitzke, Eduardo Giovanni de Oliveira Soares, Luiz Carlos Rodrigues Júnior, Luiz Carlos Rodrigues Júnior, Alessandra Peres, Alessandra Peres, Eliane Dallegrave, Kely Campos Navegantes-Lima, Marta Chagas Monteiro, Henri Stephan Schrekker, Pedro Roosevelt Torres Romão, Pedro Roosevelt Torres Romão, Pedro Roosevelt Torres Romão   +20 more
doaj   +1 more source

Comparative Genomic Analyses of New and Old World Viscerotropic Leishmanine Parasites: Further Insights into the Origins of Visceral Leishmaniasis Agents

Microorganisms, 2022
Visceral leishmaniasis (VL), also known as kala-azar, is an anthropozoonotic disease affecting human populations on five continents. Aetiologic agents belong to the Leishmania (L.) donovani complex.
Fernando Tobias Silveira, Edivaldo Costa Sousa Junior, Rodrigo Vellasco Duarte Silvestre, Thiago Vasconcelos dos Santos, Wilfredo Sosa-Ochoa, Concepción Zúniga Valeriano, Patrícia Karla Santos Ramos, Samir Mansour Moraes Casseb, Luciana Vieira do Rêgo Lima, Marliane Batista Campos, Vania Lucia da Matta, Claudia Maria Gomes, Gabriela V. Araujo Flores, Carmen M. Sandoval Pacheco, Carlos Eduardo Corbett, Márcia Dalastra Laurenti   +15 more
doaj   +1 more source

Serum Cytokine Responses over the Entire Clinical-Immunological Spectrum of Human Leishmania (L.) infantum chagasi Infection. [PDF]

Biomed Res Int, 2016
The clinical-immunological spectrum of humanLeishmania (L.) infantum chagasiinfection in Amazonian Brazil was recently reviewed based on clinical, DTH, and IFAT (IgG) evaluations that identified five profiles: three asymptomatic (asymptomatic infection, AI; subclinical resistant infection, SRI; and indeterminate initial infection, III) and two ...
Ramos PK, Carvalho KI, Rosa DS, Rodrigues AP, Lima LV, Campos MB, Gomes CM, Laurenti MD, Corbett CE, Silveira FT.   +9 more
europepmc   +4 more sources