Results 81 to 90 of about 6,523 (205)

Comparative analysis of biological aspects of Leishmania infantum strains.

PLoS ONE, 2020
Leishmania infantum infantum (LII) is one of the species that causes visceral leishmaniasis (VL) in the Old World, while L. infantum chagasi (LIC) is present in the New World.
Taiana Ferreira-Paes, Karen Dos Santos Charret, Merienny Ramos da Silva Ribeiro, Raquel Ferreira Rodrigues, Leonor Laura Leon   +4 more
doaj   +1 more source

Elevated baseline expression of seven virulence factor RNA transcripts in visceralizing species of : a preliminary quantitative PCR study

Therapeutic Advances in Infectious Disease, 2022
Introduction: Leishmaniasis is a neglected tropical disease that manifests as three major disease phenotypes: cutaneous, mucocutaneous, and visceral. In this preliminary study, we quantified virulence factor (VF) RNA transcript expression in Leishmania ...
Avinash Naraiah Mukkala, Ruwandi Kariyawasam, Rachel Lau, Braulio M. Valencia, Alejandro Llanos-Cuentas, Andrea K. Boggild   +5 more
doaj   +1 more source

Antileishmanial Activities of Carvacrol Nanoencapsulate in Biopolymeric Nanoparticles

Chemistry &Biodiversity, Volume 22, Issue 9, September 2025.
The study obtained biopolymeric nanoparticles containing carvacrol (NPCar) and evaluated their anti‐leishmanial activity. NPCar obtained presented physicochemical characteristics due to its ideal nanometric size and zeta potential, and low polydispersity index.
Joyce Cordeiro Borges, Anne Beatriz Cunha Barros, Leonardo Lima Cardoso, Tatjana de Lima Souza Keesen, Luís André de Almeida Campos, Isabella Macário Ferro Cavalcanti, Elisângela Afonso de Moura Kretzschmar   +6 more
wiley   +1 more source

Therapeutic Effect of Barberry (Berberis vulgaris) Root Extract on Experimental Cutaneous Leishmaniosis in a BALB/c Mouse Model

Veterinary Medicine and Science, Volume 11, Issue 5, September 2025.
Barberry (Berberis vulgaris) root extract shows potential in treating cutaneous leishmaniasis caused by Leishmania major. In a BALB/c mouse model, treatment significantly reduced wound size and parasite load while enhancing inflammatory markers IL‐1 and IL‐6. These results highlight barberry's therapeutic promise against leishmaniasis.
Sadegh Shirian, Morteza Norouzi Cholcheh, Saeed Habibian Dehkordi, Behnam Bakhtiari Moghadam   +3 more
wiley   +1 more source

Impact of LbSapSal Vaccine in Canine Immunological and Parasitological Features before and after Leishmania chagasi-Challenge.

PLoS ONE, 2016
Dogs represent the most important domestic reservoir of L. chagasi (syn. L. infantum). A vaccine against canine visceral leishmaniasis (CVL) would be an important tool for decreasing the anxiety related to possible L.
Lucilene Aparecida Resende, Rodrigo Dian de Oliveira Aguiar-Soares, Henrique Gama-Ker, Bruno Mendes Roatt, Ludmila Zanandreis de Mendonça, Marina Luiza Rodrigues Alves, Denise da Silveira-Lemos, Rodrigo Corrêa-Oliveira, Olindo Assis Martins-Filho, Márcio Sobreira Silva Araújo, Ricardo Toshio Fujiwara, Nelder Figueiredo Gontijo, Alexandre Barbosa Reis, Rodolfo Cordeiro Giunchetti   +13 more
doaj   +1 more source

Macrophage Polarization in the Skin Lesion Caused by Neotropical Species of Leishmania sp

Journal of Immunology Research, 2021
Macrophages play important roles in the innate and acquired immune responses against Leishmania parasites. Depending on the subset and activation status, macrophages may eliminate intracellular parasites; however, these host cells also can offer a safe ...
Carmen M. Sandoval Pacheco, Gabriela V. Araujo Flores, Kadir Gonzalez, Claudia M. de Castro Gomes, Luiz F. D. Passero, Thaise Y. Tomokane, Wilfredo Sosa-Ochoa, Concepción Zúniga, Jose Calzada, Azael Saldaña, Carlos E. P. Corbett, Fernando T. Silveira, Marcia D. Laurenti   +12 more
doaj   +1 more source

Immunological selection for Leishmania (Viannia) braziliensis antigens.

, 2002
Comparative ELISA and selective immunoblotting procedures were used in attempts to identify differential serological indicators of infection with the Leishmania (Viannia) braziliensis complex, infection with the L.
Cuba Cuba, CA, Howard, MK, Miles, MA, Ogunkolade, W   +3 more
core   +1 more source

Integration of Machine Learning‐QSAR and Polypharmacology in Drug Discovery for Leishmaniasis Using Natural and Repurposed Compounds

ChemistrySelect, Volume 10, Issue 21, June 4, 2025.
Leishmaniasis affects over 1 billion people worldwide, with current treatments limited by toxicity and efficacy. This study used machine learning (ML), QSAR, and polypharmacology to identify potential drug candidates, analyzing 12,072 compounds with random forest and XGBoost models.
Laís Salvador do Amaral, Amiel Artur Morais, Alexandre de Fátima Cobre, Raul Edison Luna Lazo, Dile Pontarolo Stremel, Jaqueline Carneiro, Luana Mota Ferreira, Roberto Pontarolo   +7 more
wiley   +1 more source

Antiprotozoal action of synthetic cinnamic acid analogs

Revista da Sociedade Brasileira de Medicina Tropical
INTRODUCTION Leishmaniasis, Chagas disease, and malaria cause morbidity globally. The drugs currently used for treatment have limitations. Activity of cinnamic acid analogs against Leishmania spp., Trypanosoma cruzi, and Plasmodium falciparum was ...
Ana Paula de Azevedo dos Santos, Saara Nery Fialho, Daniel Sol Sol de Medeiros, Ana Fidelina Gómez Garay, Jorge Alfonso Ruiz Diaz, Maria Celeste Vega Gómez, Carolina Bioni Garcia Teles, Leonardo de Azevedo Calderon   +7 more
doaj   +1 more source

Leishmania infantum chagasi in Northeastern Brazil: Asymptomatic Infection at the Urban Perimeter [PDF]

The American Society of Tropical Medicine and Hygiene, 2012
Visceral leishmaniasis (VL) is endemic in large cities in Brazil, including Natal. We determined the prevalence of asymptomatic human infection with Leishmania infantum chagasi and associated environmental risks around Natal. Infection was detected by Leishmania skin test (LST) and anti-leishmanial antibodies in humans and anti-leishmanial antibodies ...
Iraci D, Lima, Jose W, Queiroz, Henio G, Lacerda, Paula V S, Queiroz, Nubia N, Pontes, James D A, Barbosa, Daniella R, Martins, Jason L, Weirather, Richard D, Pearson, Mary E, Wilson, Selma M B, Jeronimo   +10 more
openaire   +2 more sources