Results 91 to 100 of about 15,700 (261)

Preliminary study towards a novel experimental model to study localized cutaneous leishmaniasis caused bY Leishmania (Leishmania) mexicana

Revista do Instituto de Medicina Tropical de São Paulo, 2012
There is not an experimental model of localized cutaneous leishmaniasis (LCL) caused by Leishmania (Leishmania) mexicana. The aim of the present study was to characterize the clinical and histological features of Peromyscus yucatanicus experimentally ...
Erika Ivett Sosa-Bibiano, Nicole Raymonde Van Wynsberghe, Silvia Beatriz Canto-Lara, Fernando Jose Andrade-Narvaez   +3 more
doaj   +1 more source

Efficacy of Thermotherapy to Treat Cutaneous Leishmaniasis Caused by Leishmania tropica in Kabul, Afghanistan: A Randomized, Controlled Trial [PDF]

, 2005
BACKGROUND: Pentavalent antimony is the agent recommended for treatment of cutaneous leishmaniasis (CL). Its use is problematic, because it is expensive and because of the potential for drug-associated adverse effects during a lengthy and painful ...
Aram H, Arana BA, Babajev KB, Berman JD, Berman JD, C. R. Davies, J. Kolaczinski, J. R. David, Junaid AJN, M. Bismullah, M. Mohsen, M. Wahid, Navin TR, Neva FA, Noyes H, R. J. Quinnell, R. Reithinger, Reithinger R, Rodriguez ME, Sacks DL, Sharquie KE, Tallab TM, Velasco-Castrejon O, World Health Organization   +23 more
core   +1 more source

The Inactive X Chromosome: A Genetic Driver of Female‐Biased Rheumatic Autoimmune Disorders?

European Journal of Immunology, Volume 55, Issue 5, May 2025.
Recent works indicate that several X‐linked genetic mechanisms contribute to the female predisposition for autoimmune diseases. Here, we review the recent findings that underscore the significance of the alteration of X chromosome inactivation (XCI) maintenance and the putative role of the long noncoding XIST/Xist RNA in this process but also as a sex ...
Léa Ferrayé, Mélissa Nieucel, Magali Savignac, Julie Chaumeil, Jean‐Charles Guéry   +4 more
wiley   +1 more source

Neuroimmune Pain and Its Manipulation by Pathogens

Evolutionary Applications, Volume 18, Issue 4, April 2025.
ABSTRACT Recent studies highlight extensive crosstalk that exists between sensory neurons responsible for pain and the immune system. Cutaneous pain neurons detect harmful microbes, recruit immune cells, and produce anticipatory immunity in nearby tissues. These complementary systems generally protect hosts from infections.
Kevin W. Lozo, Athena Aktipis, Joe Alcock   +2 more
wiley   +1 more source

Development of NanoLuc-PEST expressing Leishmania mexicana as a new drug discovery tool for axenic- and intramacrophage-based assays [PDF]

, 2018
The protozoan parasite Leishmania causes leishmaniasis; a spectrum of diseases of which there are an estimated 1 million new cases each year. Current treatments are toxic, expensive, difficult to administer, and resistance to them is emerging.
Berry, SL, Hameed, H, Horrocks, P, Maciej-Hulme, ML, Price, HP, Saif Abou-Akkada, S, Thomason, A   +6 more
core   +7 more sources

LOPAC library screening identifies suramin as a TRIM21 binder with a unique binding mode revealed by crystal structure

Acta Crystallographica Section F, Volume 81, Issue 3, Page 101-107, March 2025.
This communication describes the crystal structure of TRIM21 in complex with suramin, providing new opportunities to target this E3 ligase.Differential scanning fluorimetry screening of the Library of Pharmacologically Active Compounds (LOPAC) identified four hits for the PRYSPRY domain of the human E3 ligase tripartite motif‐containing protein 21 ...
Yeojin Kim, Stefan Knapp, Andreas Krämer   +2 more
wiley   +1 more source

PubChem BioAssays 1063: A Poorly Exploited Source of New Antileishmanial Compounds

Journal of Parasitology Research
PubChem Bioassays (AID 1063) reported the in vitro testing of 196,141 compounds against Leishmania major promastigotes. Although these results have been publicly available since 2008, limited efforts on further testing of some of these compounds has been
Sergio Sifontes-Rodríguez, Susana Meneses-Gómez, Alma Reyna Escalona-Montaño, Daniel Andrés Sánchez-Almaraz, Ofelia Pérez-Olvera, Aranza Regina Cañón Rosas, Pedro Zuriel Cruz Bautista, María Magdalena Aguirre-García   +7 more
doaj   +1 more source

Características epidemiológicas da leishmaniose tegumentar americana em uma região endêmica do Estado da Bahia : II leishmaniose canina [PDF]

, 1984
Um inquérito em cães realizado na região de Três Braços, Bahia, mostrou que 3,0% de 98 animais tinham amastigotas em lesões de pele. Parasitos não foram encontrados em pele normal da orelha.
Barretto, Air C., Cuba, César Augusto Cuba, Magalhães, Albino Verçosa de, Marsden, Philip Davis, Rosa, Ana de Cassia Oliveira Cardoso, Vexenat, Júlio A.   +5 more
core   +3 more sources

Cutaneous Leishmaniasis Mimicking a Nasal Tumor: A Case Report

Case Reports in Infectious Diseases, Volume 2025, Issue 1, 2025.
Leishmaniasis is a disease caused by Leishmania protozoa that is transmitted to the patient by sand flies. Depending on the Leishmania species, the disease can present with cutaneous, mucosal, or multiorgan involvement. Cutaneous leishmaniasis can present with diverse clinical manifestations mimicking other diseases.
Maryam Hekmat, Mohammad Reza Namazi, Amir Hossein Najibi, Babak Shirazi Yeganeh, Negin Fazelzadeh Haghighi, Larry M. Bush   +5 more
wiley   +1 more source

Distinct roles in autophagy and importance in infectivity of the two ATG4 cysteine peptidases of leishmania major [PDF]

, 2012
Macroautophagy in Leishmania, which is important for the cellular remodeling required during differentiation, relies upon the hydrolytic activity of two ATG4 cysteine peptidases (ATG4.1 and ATG4.2).
Afonso, Azad, Besteiro, Betin, Betin, Bhattacharya, Boya, Cabrera, Dalle-Donne, Deretic, Dolai, Dolai, Garami, Geng, Goldman, Graef, Graham H. Coombs, Hosokawa, Jeremy C. Mottram, Kim, Kimura, Kimura, Kirisako, Kirisako, Krebiehl, Köchl, Lee, Lemasters, Li, Manjithaya, Mariño, Mariño, Mariño, Medina-Acosta, Misslitz, Mortensen, Mottram, Mörck, Mörck, Nair, Okamoto, Read, Roderick A.M. Williams, Sacks, Schapira, Scherz-Shouval, Scherz-Shouval, Scherz-Shouval, Scherz-Shouval, Tanida, Tanida, Williams, Williams, Williams, Williams, Wong, Xie, Yoshimoto, Youle   +58 more
core   +1 more source