Results 71 to 80 of about 9,040 (224)

Pathogenic Significance of Trypanosomatids: Progress in Drug Resistance, Control Strategies, and Artificial Intelligence

Interdisciplinary Perspectives on Infectious Diseases, Volume 2026, Issue 1, 2026.
Trypanosomatids, including the genera Trypanosoma and Leishmania, are protozoan parasites of significant medical and veterinary relevance. These organisms cause African trypanosomiasis, Chagas disease, and leishmaniasis, which are classified as neglected tropical diseases (NTDs).
Cynthia Mmalebna Amisigo, Aboagye Kwarteng Dofuor, Jennifer Afua Afrifa Yamoah, Albert Fynn Aiduenu, Blessing Kwabena Gayi, Angelina Akomea, Zenabu Lansah Alidu, Gideon Danso, Selina Mawunyo Ayivi-Tosuh, Naa Kwarley-Aba Quartey, Joseph Harold Nyarko Osei, Seyram Kofi Loh, William Ekloh, Suraiya Saleem   +13 more
wiley   +1 more source

Structure of Leishmania mexicana lipophosphoglycan.

Journal of Biological Chemistry, 1992
Lipophosphoglycan (LPG) was isolated from the culture supernatant of Leishmania mexicana promastigotes and its structure elucidated by a combination of 1H NMR, fast atom bombardment mass spectrometry, methylation analysis, and chemical and enzymatic modifications. It consists of the repeating phosphorylated oligosaccharides PO4-6Gal beta 1-4Man alpha 1-
Ilg, Thomas, Etges, Robert, Overath, Peter, McConville, Malcolm J., Thomas-Oates, Jane, Thomas, Jerry, Homans, Steven W., Ferguson, Michael A.   +7 more
openaire   +2 more sources

Functional analysis of leishmania cyclopropane fatty acid synthetase [PDF]

, 2012
The single gene encoding cyclopropane fatty acid synthetase (CFAS) is present in Leishmania infantum, L. mexicana and L. braziliensis but absent from L. major, a causative agent of cutaneous leishmaniasis. In L.
Mottram Jeremy C., Evans, K.J., Samuel O. Oyola (112546), Barbara A. Smith (112553), Smith, Barbara A., Terry K Smith, Smith Barbara A., Samuel O Oyola, Smith, Deborah F., Paul M Kaye, James D. Hilley (112558), Kaye, Paul M., Evans, Krystal J., Smith, Terry K., Smith, B.A., Oyola, Samuel O., Hilley, J.D., Mottram, J.C., Kaye, P.M., Oyola, S.O., Jeremy C. Mottram (112563), Smith Terry K., Terry K. Smith (112550), Smith, D.F., Mottram, Jeremy C., Hilley James D., Oyola Samuel O., Paul M. Kaye (54054), Deborah F. Smith (112029), Krystal J Evans, Evans Krystal J., Jeremy C Mottram, Kaye Paul M., James D Hilley, Smith, T.K., Barbara A Smith, Krystal J. Evans (112547), Smith Deborah F., Deborah F Smith, Hilley, James D.   +39 more
core   +1 more source

Leishmaniasis Transmission Risk at the Forest‐Peridomestic Interface in an Area of Southern Sinaloa, Mexico: Entomological, Molecular, and Climatic Evidence

Journal of Parasitology Research, Volume 2026, Issue 1, 2026.
Leishmaniasis, caused by Leishmania spp. and transmitted by phlebotomine sand flies, affects almost 1,000,000 people annually across more than 90 countries. In Mexico, growing evidence of locally acquired transmission in northwestern states makes ecoepidemiological work increasingly urgent.
Juan José Ríos Tostado, Hipólito Castillo Ureta, José Israel Torres Avendaño, José Marcial Zazueta Moreno, César Enrique Romero Higareda, Luz Isela Peinado Guevara, Annete Itzel Apodaca Medina, Edith Hilario Torres Montoya, Satabdi Datta Choudhury   +8 more
wiley   +1 more source

Ecotin-like serine peptidase inhibitor ISP1 of Leishmania major plays a role in flagellar pocket dynamics and promastigote differentiation [PDF]

, 2012
Leishmania ISPs are ecotin-like natural peptide inhibitors of trypsin-family serine peptidases, enzymes that are absent from the Leishmania genome. This led to the proposal that ISPs inhibit host serine peptidases and we have recently shown that ISP2 ...
Petr Volf, Mottram, Jeremy C, Gareth D. Westrop, Eschenlauer, Sylvain C, Volf, Petr, Amy Goundry, Sylvain C. Eschenlauer, Jeremy C. Mottram, Lima, Ana Paula C A, Lima, Ana Paula C.A., Morrison, Lesley S, Morrison, Lesley S., Lesley S. Morrison, Ana Paula C. A. Lima, Goundry, Amy, Faria, Marilia S, Marilia S. Faria, Graham H. Coombs, Westrop, Gareth D., Coombs, Graham H, Anna Dostalova, Laurence Tetley, Faria, Marilia S., Tetley, Laurence, Dostalova, Anna, Westrop, Gareth D, Mottram, Jeremy C., Eschenlauer, Sylvain C., Coombs, Graham H.   +28 more
core   +1 more source

Analysis of Kinetoplast DNA from Mexican Isolates of Leishmania (L.) mexicana

Interdisciplinary Perspectives on Infectious Diseases, 2012
This study analyzed DNA minicircles of Mexican isolates of L. (Leishmania) mexicana to look for genetic differences between strains isolated from patients with diffuse cutaneous (DCL) and localized (LCL) leishmaniasis.
Omar Hernández-Montes, Saúl González Guzmán, Federico Martínez Gómez, Douglas C. Barker, Amalia Monroy-Ostria   +4 more
doaj   +1 more source

Prevalence of Leishmania species among patients with cutaneous leishmaniasis in Qassim province of Saudi Arabia

BMC Public Health, 2019
Background Leishmaniasis is a parasitic infection endemic in more than ninety countries of the world. The cutaneous leishmaniasis (CL) is a most common form of leishmaniasis and it remains to be a major public health issue in Saudi Arabia. This study was
Zafar Rasheed, Ahmed A. Ahmed, Tarek Salem, Mohammed S. Al-Dhubaibi, Ahmad A. Al Robaee, Abdullateef A. Alzolibani   +5 more
doaj   +1 more source

Evidence Gaps and Global Patterns in Leishmaniasis Control: A Scoping Review of Clinical, Diagnostic, and Treatment Strategies

Journal of Parasitology Research, Volume 2026, Issue 1, 2026.
Background Leishmaniasis is a neglected tropical disease with diverse clinical forms, heterogeneous geographical distribution, and persistent diagnostic and treatment challenges. Although substantial primary research exists, evidence remains fragmented, limiting integrated and context‐specific control strategies.
Muhi-deen Wonwana Mohammed, Yussif Owusu Aboagye, Akwasi Anyanful, Samuel Kyei, Kwame Kumi Asare, Pengfei Cai   +5 more
wiley   +1 more source

Activity of Hydroxyurea against Leishmania mexicana [PDF]

Antimicrobial Agents and Chemotherapy, 2008
ABSTRACT Leishmania mexicana is a protozoan parasite that causes a disease in humans with frequent relapses after treatment. It is also highly resistant to the currently available drugs. For this reason, there is an urgent need for more effective antileishmanial drugs.
Hugo, Martinez-Rojano, Javier, Mancilla-Ramirez, Laura, Quiñonez-Diaz, Norma, Galindo-Sevilla   +3 more
openaire   +2 more sources

T helper1/T helper2 cells and resistance/susceptibility to Leishmania infection : is this paradigm still relevant?

, 2012
Work in large part on Leishmania major in the 1980s identified two distinct apparently counter-regulatory CD4 T cell populations, T helper (h)1 and Th2, that controlled resistance/susceptibility to infection respectively.
Brombacher, F., James eAlexander, Frank Brombacher, Frank eBrombacher, Alexander, J., James Alexander   +5 more
core   +1 more source