Results 71 to 80 of about 14,552 (222)

Deletion of transketolase triggers a stringent metabolic response in promastigotes and loss of virulence in amastigotes of Leishmania mexicana [PDF]

, 2018
Transketolase (TKT) is part of the non-oxidative branch of the pentose phosphate pathway (PPP). Here we describe the impact of removing this enzyme from the pathogenic protozoan Leishmania mexicana.
A Chokkathukalam, A Garami, A Garami, A Lal, A Misslitz, A Mukherjee, A Seyfang, A Stincone, Andrew W. Pountain, AT Cordeiro, B Giardine, B Langmead, B Raz, BM Bakker, C Trapnell, CN Cronin, D Rodriguez-Contreras, D Rodriguez-Contreras, DA Maugeri, DA Maugeri, David Wildridge, DH Kim, DJ Creek, DJ Creek, DJ Creek, DT Hart, E Afgan, E Tetaud, EC Saunders, EC Saunders, EJ Kerkhoven, F Achcar, Fiona Achcar, FP Keegan, Frédéric Bringaud, GB Moorhead, IM-J Xu, J Faria, J Kloehn, J Kovarova, J Xia, JE Ralton, JR Dusick, Julie Kovářová, K Leifso, L Wu, M Silverberg, MA Comini, MB Hughes, MG De Vas, Michael P. Barrett, MJ McConville, NJ Veitch, P Kaye, PA Bates, PA Michels, PJ Alcolea, PJ Alcolea, R Bais, R Mancilla, RA Scheltema, RH Villet, Richard J. S. Burchmore, RJ Burchmore, RJ Kleijn, S Allmann, S Langbein, S Weidt, SA Stoffel, SH Lee, Stefan Weidt, T Naderer, T Naderer, Thomas Naderer, TR Holzer, W Moreira, WI Staiger, WN Lee, Z Lobo   +78 more
core   +11 more sources

Structure of Leishmania mexicana lipophosphoglycan.

Journal of Biological Chemistry, 1992
Lipophosphoglycan (LPG) was isolated from the culture supernatant of Leishmania mexicana promastigotes and its structure elucidated by a combination of 1H NMR, fast atom bombardment mass spectrometry, methylation analysis, and chemical and enzymatic modifications. It consists of the repeating phosphorylated oligosaccharides PO4-6Gal beta 1-4Man alpha 1-
Ilg, Thomas, Etges, Robert, Overath, Peter, McConville, Malcolm J., Thomas-Oates, Jane, Thomas, Jerry, Homans, Steven W., Ferguson, Michael A.   +7 more
openaire   +2 more sources

Activity of Hydroxyurea against Leishmania mexicana [PDF]

Antimicrobial Agents and Chemotherapy, 2008
ABSTRACT Leishmania mexicana is a protozoan parasite that causes a disease in humans with frequent relapses after treatment. It is also highly resistant to the currently available drugs. For this reason, there is an urgent need for more effective antileishmanial drugs.
Hugo, Martinez-Rojano, Javier, Mancilla-Ramirez, Laura, Quiñonez-Diaz, Norma, Galindo-Sevilla   +3 more
openaire   +2 more sources

The Safety and Efficacy of an Immunomodulator Garlic‐Based Cream (LeishG1) for Treating Uncomplicated Cutaneous Leishmaniasis: A Single‐Blind, Multi‐Center Study

Health Science Reports, Volume 8, Issue 12, December 2025.
ABSTRACT Background and Aims Cutaneous leishmaniasis (CL) is a major problem in developing nations, particularly in the Middle East. Novel herbal treatment options may provide a safe alternative associated with favorable outcomes in CL lesion healing.
Fatemeh Emadi, Zohreh Khodashenas, Azadeh Rashidi, Ali Khamesipour, Mehdi Zaboli, Mehri Ghafourian, Mohammad Mehdi Naghizadeh, Fatemeh Tuserkani, Tooba Ghazanfari   +8 more
wiley   +1 more source

Local Skin Inflammation in Cutaneous Leishmaniasis as a Source of Variable Pharmacokinetics and Therapeutic Efficacy of Liposomal Amphotericin B. [PDF]

, 2018
Disfiguring skin lesions caused by several species of the Leishmania parasite characterize cutaneous leishmaniasis (CL). Successful treatment of CL with intravenous (i.v.) liposomal amphotericin B (LAmB) relies on the presence of adequate antibiotic ...
Alavijeh, Mo, Croft, Simon L, Fortes Francisco, Amanda, Harris, Andy, Murdan, Sudaxshina, Van Bocxlaer, Katrien, Wijnant, Gert-Jan, Yardley, Vanessa   +7 more
core   +2 more sources

World Association for Veterinary Dermatology Consensus Statement for Diagnosis, and Evidence‐Based Clinical Practice Guidelines for Treatment and Prevention of Canine Leishmaniosis

Veterinary Dermatology, Volume 36, Issue 6, Page 723-787, December 2025.
Hyperkeratosis of (a) the footpads and (b) the nasal planum. ABSTRACT Background Canine leishmaniosis (CanL) due to Leishmania infantum remains common, and veterinarians do not always follow scientifically sound approaches for diagnosis, treatment and prevention. Objectives To provide consensus guidelines for diagnosis and evidence‐based guidelines for
Manolis N. Saridomichelakis, Gad Baneth, Silvia Colombo, Filipe Dantas‐Torres, Lluís Ferrer, Alessandra Fondati, Guadalupe Miró, Laura Ordeix, Domenico Otranto, Chiara Noli   +9 more
wiley   +1 more source

Analysis of Kinetoplast DNA from Mexican Isolates of Leishmania (L.) mexicana

Interdisciplinary Perspectives on Infectious Diseases, 2012
This study analyzed DNA minicircles of Mexican isolates of L. (Leishmania) mexicana to look for genetic differences between strains isolated from patients with diffuse cutaneous (DCL) and localized (LCL) leishmaniasis.
Omar Hernández-Montes, Saúl González Guzmán, Federico Martínez Gómez, Douglas C. Barker, Amalia Monroy-Ostria   +4 more
doaj   +1 more source

Prevalence of Leishmania species among patients with cutaneous leishmaniasis in Qassim province of Saudi Arabia

BMC Public Health, 2019
Background Leishmaniasis is a parasitic infection endemic in more than ninety countries of the world. The cutaneous leishmaniasis (CL) is a most common form of leishmaniasis and it remains to be a major public health issue in Saudi Arabia. This study was
Zafar Rasheed, Ahmed A. Ahmed, Tarek Salem, Mohammed S. Al-Dhubaibi, Ahmad A. Al Robaee, Abdullateef A. Alzolibani   +5 more
doaj   +1 more source

Secretory pathway of trypanosomatid parasites [PDF]

, 2002
The Trypanosomatidae comprise a large group of parasitic protozoa, some of which cause important diseases in humans. These include Tryanosoma brucei (the causative agent of African sleeping sickness and nagana in cattle), Trypanosoma cruzi (the causative
McConville, Malcolm J., Mullin, Kylie A., Ilgoutz, Steven C., Teasdale, Rohan D.   +3 more
core   +1 more source

Effects of TcFLA‐1BP and TcGP72 Deletion on the Infectivity and Survival of Trypanosoma cruzi in Cell Cultures

Cell Biology International, Volume 49, Issue 11, Page 1395-1410, November 2025.
ABSTRACT Chagas disease, caused by the protozoan Trypanosoma cruzi, is a neglected tropical disease with limited treatment options and no available vaccine. Understanding the role of proteins in the parasite's biological cycle is critical for advancing vaccine development and optimizing therapies.
Normanda Souza‐Melo, Giovanna Henriques de Souza, Wanderley de Souza   +2 more
wiley   +1 more source