Results 81 to 90 of about 9,040 (224)

"Leishmania infantum" : molecular analysis for identification of potential virulence factors and genes of diagnostic use [PDF]

, 2004
Leishmania infantum is the causative agents of zoonotic visceral leishmaniasis, a fatal disease if left untreated. In Southern Europe, the number of HIV/Leishmania infantum co-infections is increasing and becomes an emerging concern for the public health.
Niederwieser, Igor
core   +1 more source

Eprinomectin Inhibits Leishmania by Inducing Mitochondrial Dysfunction and Cell Cycle Arrest

Transboundary and Emerging Diseases, Volume 2026, Issue 1, 2026.
Introduction Leishmaniasis remains a significant global health challenge, with current therapies often hampered by toxicity, resistance, and high cost. In this study, we investigated the antileishmanial potential of eprinomectin, a veterinary macrocyclic lactone, to address unmet therapeutic needs.
Mengtao Yu, Jiale Guo, Wenqi Liu, Yan Li, B. Shen   +4 more
wiley   +1 more source

MAP kinase phosphatase-2 plays a critical role in response to infection by Leishmania mexicana

, 2010
In this study we generated a novel dual specific phosphatase 4 (DUSP4) deletion mouse using a targeted deletion strategy in order to examine the role of MAP kinase phosphatase-2 (MKP-2) in immune responses.
Juliane Schroeder, Plevin Robin, Kurnik Magdalena, H. Adrienne McGachy, Shweash, M.S., Cadalbert Laurence C., H Adrienne McGachy, Callum M Sloss, James Alexander, Shweash Muhannad, Bryant, C.E., Laurence C Cadalbert, Cadalbert, L.C., Clare E Bryant, Laurence C. Cadalbert, Alexander, James, Mashael S Al-Mutairi, Muhannad Shweash, Al-Mutairi Mashael S., Al-Mutairi, M.S., Schroeder Juliane, Callum M. Sloss, Alexander James, Robin Plevin, Sloss Callum M., Schroeder, J., Plevin, R.J., Sloss, C.M., Mashael S. Al-Mutairi, McGachy, H.A., Clare E. Bryant, McGachy H. Adrienne, Bryant Clare E., Magdalena Kurnik, Kurnik, M.   +34 more
core   +1 more source

Human Chemokines as Antimicrobial Peptides with Direct Parasiticidal Effect on Leishmania mexicana In Vitro [PDF]

, 2013
Chemokines and chemokine receptor-mediated effects are important mediators of the immunological response and cure in human leishmaniasis. However, in addition to their signalling properties for leukocytes, many chemokines have also been shown to act ...
Paul Bates (134046), Shannon, Oonagh, Sara K Söbirk, Söbirk, Sara K, Arne Egesten, Mattias Collin (62685), Egesten, Arne, Arne Egesten (365606), Oonagh Shannon (194608), Matthias Mörgelin, Mörgelin, Matthias, Sara K. Söbirk (393666), Mattias Collin, Collin, Mattias, Bates, Paul, Matthias Mörgelin (109607), Oonagh Shannon, Karlsson Söbirk, Sara, Paul Bates   +18 more
core   +1 more source

In vitro evaluation and in vivo efficacy of nitroimidazole‑sulfanyl ethyl derivatives against Leishmania (V.) braziliensis and Leishmania (L.) mexicana

, 2021
The aim of this study was to synthesize several small molecules of the type 5-nitroimidazole-sulfanyl and evaluate biological properties against the main Leishmania species that cause cutaneous leishmaniasis in Venezuela.
Charris, Jaime E., Oviedo, Henry J., Rodríguez, Noris M., Charris, Jaime, Blanco, Zuleima, Mijares, Michael R., Ramírez, Hegira, Fernández Moreira, Esteban   +7 more
core   +1 more source

A canine model of experimental infection with Leishmania (L.) mexicana

Parasites & Vectors, 2014
Background Cutaneous leishmaniasis is a tropical disease affecting over one million patients annually and Leishmania (L.) mexicana is one of the major etiological agents in the Americas. Here we established the first experimental infection of L.
Julio Vladimir Cruz-Chan, Amarú del Carmen Aguilar-Cetina, Liliana Estefanía Villanueva-Lizama, Pedro Pablo Martínez-Vega, Maria Jesús Ramírez-Sierra, Miguel Enrique Rosado-Vallado, José Leonardo Guillermo-Cordero, Eric Dumonteil   +7 more
doaj   +1 more source

The susceptibility of wild caught sand flies to infection by a subspecies of Leishmania mexicana isolated from proechimys iheringi denigratus (Rodentia, echimyidae)

Memorias do Instituto Oswaldo Cruz, 1986
Several species of wild caught sand flies were collected in the same site where a subspecies of leishmania mexicana was isolated from the rodent Proechimys iheringi denigratus.
Air C. Barretto, Julio A. Vexenat, Norman E. Peterson   +2 more
doaj   +1 more source

The Safety and Efficacy of an Immunomodulator Garlic‐Based Cream (LeishG1) for Treating Uncomplicated Cutaneous Leishmaniasis: A Single‐Blind, Multi‐Center Study

Health Science Reports, Volume 8, Issue 12, December 2025.
ABSTRACT Background and Aims Cutaneous leishmaniasis (CL) is a major problem in developing nations, particularly in the Middle East. Novel herbal treatment options may provide a safe alternative associated with favorable outcomes in CL lesion healing.
Fatemeh Emadi, Zohreh Khodashenas, Azadeh Rashidi, Ali Khamesipour, Mehdi Zaboli, Mehri Ghafourian, Mohammad Mehdi Naghizadeh, Fatemeh Tuserkani, Tooba Ghazanfari   +8 more
wiley   +1 more source

Molecular mechanisms of drug resistance in natural Leishmania populations vary with genetic background [PDF]

, 2012
The evolution of drug-resistance in pathogens is a major global health threat. Elucidating the molecular basis of pathogen drug-resistance has been the focus of many studies but rarely is it known whether a drug-resistance mechanism identified is ...
Sylke Müller, Hideo Imamura (62469), Dujardin, J., Khanal, Basudha, Brunker, K., Brunker, Kirstyn, Kirstyn Brunker (181178), Graham H. Coombs (164011), Suman Rijal (181185), Imamura, Hideo, Jean-Claude Dujardin, M\ufcller, Sylke, Dujardin, Jean-Claude, Dujardin, J. C., Coombs, G. H., Muller, S., Jean-Claude Dujardin (56958), Decuypere, S., Coombs, G.H., Vanaerschot, M., Decuypere, Saskia, Coombs, Graham H, Rijal, S., Manu Vanaerschot, Sylke Müller (37476), Basudha Khanal, Khanal, B., Hideo Imamura, Kirstyn Brunker, Müller, Sylke, Coombs, Graham H., Vanaerschot, Manu, Imamura, H., Rijal, Suman, Saskia Decuypere, Basudha Khanal (181181), Saskia Decuypere (181176), Manu Vanaerschot (109210), Suman Rijal, Graham H Coombs   +39 more
core   +1 more source

Preliminary study towards a novel experimental model to study localized cutaneous leishmaniasis caused bY Leishmania (Leishmania) mexicana

Revista do Instituto de Medicina Tropical de São Paulo, 2012
There is not an experimental model of localized cutaneous leishmaniasis (LCL) caused by Leishmania (Leishmania) mexicana. The aim of the present study was to characterize the clinical and histological features of Peromyscus yucatanicus experimentally ...
Erika Ivett Sosa-Bibiano, Nicole Raymonde Van Wynsberghe, Silvia Beatriz Canto-Lara, Fernando Jose Andrade-Narvaez   +3 more
doaj   +1 more source