Results 91 to 100 of about 9,040 (224)

World Association for Veterinary Dermatology Consensus Statement for Diagnosis, and Evidence‐Based Clinical Practice Guidelines for Treatment and Prevention of Canine Leishmaniosis

Veterinary Dermatology, Volume 36, Issue 6, Page 723-787, December 2025.
Hyperkeratosis of (a) the footpads and (b) the nasal planum. ABSTRACT Background Canine leishmaniosis (CanL) due to Leishmania infantum remains common, and veterinarians do not always follow scientifically sound approaches for diagnosis, treatment and prevention. Objectives To provide consensus guidelines for diagnosis and evidence‐based guidelines for
Manolis N. Saridomichelakis, Gad Baneth, Silvia Colombo, Filipe Dantas‐Torres, Lluís Ferrer, Alessandra Fondati, Guadalupe Miró, Laura Ordeix, Domenico Otranto, Chiara Noli   +9 more
wiley   +1 more source

A real-time PCR assay to estimate Leishmania chagasi load in its natural sand fly vector Lutzomyia longipalpis [PDF]

, 2008
Leishmania chagasi, transmitted mainly by Lutzomyia longipalpis sand flies, causes visceral leishmaniasis and atypical cutaneous leishmaniasis in Latin America.
Bates, Paul A., Maingon, Rhayza D.C., Ranasinghe, Shalindra, Ranasinghe, S., Rogers, Matthew E., Hamilton, J. G. C., Maingon, Rhayza DC, Rogers, Matthew E, Bates, Paul, Hamilton, James G C, Maingon, Rhayza D C, Hamilton, James GC, Maingon, R. D. C., Hamilton, James G.C., Bates, Paul A   +14 more
core   +1 more source

Effects of TcFLA‐1BP and TcGP72 Deletion on the Infectivity and Survival of Trypanosoma cruzi in Cell Cultures

Cell Biology International, Volume 49, Issue 11, Page 1395-1410, November 2025.
ABSTRACT Chagas disease, caused by the protozoan Trypanosoma cruzi, is a neglected tropical disease with limited treatment options and no available vaccine. Understanding the role of proteins in the parasite's biological cycle is critical for advancing vaccine development and optimizing therapies.
Normanda Souza‐Melo, Giovanna Henriques de Souza, Wanderley de Souza   +2 more
wiley   +1 more source

Complete Resolution of Cutaneous Leishmaniasis With a Novel Topical Combination Therapy: A Case Series

Clinical Case Reports, Volume 13, Issue 10, October 2025.
ABSTRACT Cutaneous leishmaniasis (CL) remains a therapeutic challenge in endemic regions, with 600,000–1 million new cases annually facing limited treatment options. We present a case series evaluating an innovative topical combination therapy for acute‐phase CL in Shiraz, Iran.
Hoda Haghshenas, Aref Ghanaatpisheh, Mohammad Darayesh, Elaheh Entezar Almahdi   +3 more
wiley   +1 more source

Glucose Transporters and Virulence in Leishmania mexicana

mSphere, 2018
Glucose transport plays important roles for in vitro growth of insect-stage promastigotes and especially for viability of intramacrophage mammalian host-stage amastigotes of Leishmania mexicana .
Xiuhong Feng, Khoa D. Tran, Marco A. Sanchez, Hakima Al Mezewghi, Scott M. Landfear   +4 more
openaire   +3 more sources

Biphenylquinuclidines as inhibitors of squalene synthase and growth of parasitic protozoa.

, 2005
In this paper we describe the preparation of some biphenylquinuclidine derivatives and their evaluation as inhibitors of squalene synthase in order to explore their potential in the treatment of the parasitic diseases leishmaniasis and Chagas disease ...
Croft, Simon L, Cammerer, Simon, Gilbert, Ian H, Orenes Lorente, Silvia, Ruiz Perez, Luis M, Urbina, Julio, Gonzalez Pacanowska, Dolores, Jiménez, Carmen, Pacanowska, Dolores Gonzalez, de Luca-Fradley, Kate, Gómez, Rosario, Perez, Luis M. Ruiz, Gilbert, Ian H., Lorente, Silvia Orenes, Yardley, Vanessa, Croft, Simon L.   +15 more
core   +1 more source

PubChem BioAssays 1063: A Poorly Exploited Source of New Antileishmanial Compounds

Journal of Parasitology Research
PubChem Bioassays (AID 1063) reported the in vitro testing of 196,141 compounds against Leishmania major promastigotes. Although these results have been publicly available since 2008, limited efforts on further testing of some of these compounds has been
Sergio Sifontes-Rodríguez, Susana Meneses-Gómez, Alma Reyna Escalona-Montaño, Daniel Andrés Sánchez-Almaraz, Ofelia Pérez-Olvera, Aranza Regina Cañón Rosas, Pedro Zuriel Cruz Bautista, María Magdalena Aguirre-García   +7 more
doaj   +1 more source

Production of the Antimicrobial Roseoflavin With Genetically Engineered Corynebacterium glutamicum

Microbial Biotechnology, Volume 18, Issue 10, October 2025.
Corynebacterium glutamicum was genetically engineered for the production of the riboflavin analog roseoflavin, while minimising its antimicrobial effects. To this end, the genetic machinery from the natural roseoflavin producer Streptomyces davaonensis was evaluated in a riboflavin‐producing C. glutamicum strain.
Luciana Fernandes Brito, Ane Bræin Aas, Rosa Jodalen Rudberg, Trygve Brautaset, Fernando Pérez‐García   +4 more
wiley   +1 more source

Leishmania infantum proteophosphoglycans regurgitated by the bite of its natural sand fly vector, Lutzomyia longipalpis, promote parasite establishment in mouse skin and skin-distant tissues

, 2010
We demonstrate that a proteophosphoglycan-rich gel secreted by Leishmania infantum inside the midgut of Lutzomyia longipalpis sand flies (promastigote secretory gel) is regurgitated along with an average dose of 500 L.
Müller, Ingrid, Bates, Paul Andrew, Corware, Karina, Matthew Edward Rogers, Karina Corware, Rogers, Matthew Edward, Paul Andrew Bates, Ingrid Müller   +7 more
core   +1 more source

Metabolic variation during development in culture of Leishmania donovani promastigotes

, 2011
The genome sequencing of several Leishmania species has provided immense amounts of data and allowed the prediction of the metabolic pathways potentially operating.
Cordeiro-da-Silva, Anabela, Coombs, Graham H, Silva, Ana Marta, Ana Marta Silva, Anabela Cordeiro-da-Silva, Silva Ana Marta, Coombs Graham H., Cordeiro-da-Silva Anabela, Graham H Coombs   +8 more
core   +1 more source