Results 91 to 100 of about 14,552 (222)

PubChem BioAssays 1063: A Poorly Exploited Source of New Antileishmanial Compounds

Journal of Parasitology Research
PubChem Bioassays (AID 1063) reported the in vitro testing of 196,141 compounds against Leishmania major promastigotes. Although these results have been publicly available since 2008, limited efforts on further testing of some of these compounds has been
Sergio Sifontes-Rodríguez, Susana Meneses-Gómez, Alma Reyna Escalona-Montaño, Daniel Andrés Sánchez-Almaraz, Ofelia Pérez-Olvera, Aranza Regina Cañón Rosas, Pedro Zuriel Cruz Bautista, María Magdalena Aguirre-García   +7 more
doaj   +1 more source

Leishmania infantum and Leishmania braziliensis : differences and similarities to evade the innate immune system [PDF]

, 2016
Visceral leishmaniasis is a severe form of the disease, caused by Leishmania infantum in the New World. Patients present an anergic immune response that favors parasite establishment and spreading through tissues like bone marrow and liver.
Bernardes, Daniela M., Falcão, Sarah de Athayde Couto, Favali, Cecilia Beatriz Fiuza, Ferreira, Luciana G., Jaramillo, Tatiana María Giraldo, Santana, Jaime Martins de   +5 more
core   +2 more sources

Glucose Transporters and Virulence in Leishmania mexicana

mSphere, 2018
Glucose transport plays important roles for in vitro growth of insect-stage promastigotes and especially for viability of intramacrophage mammalian host-stage amastigotes of Leishmania mexicana .
Xiuhong Feng, Khoa D. Tran, Marco A. Sanchez, Hakima Al Mezewghi, Scott M. Landfear   +4 more
openaire   +3 more sources

IL‐12 and IFN‐γ in Response to Leishmania Infantum Antigens in Felines From an Endemic Area for Visceral Leishmaniasis

Parasite Immunology, Volume 47, Issue 8, August 2025.
ABSTRACT Visceral leishmaniasis is a potentially fatal zoonosis with an increasing incidence. Most infected felines present the disease in its subclinical form and demonstrate greater resistance to parasitemia than dogs. However, the role of cellular immunity in felines is still poorly understood. This study measured serum levels of interleukin (IL)‐12
João Victor Lé Lode, Lucas Takeshi Siqueira Ito, Gisele Mitsue Umino, Valéria Marçal Felix de Lima   +3 more
wiley   +1 more source

Analysis by RNA-seq of transcriptomic changes elicited by heat shock in Leishmania major [PDF]

, 2019
Besides their medical relevance, Leishmania is an adequate model for studying post-transcriptional mechanisms of gene expression. In this microorganism, mRNA degradation/stabilization mechanisms together with translational control and post-translational ...
Aguado, Begoña, Corvo, Laura, Lombraña, Rodrigo, Rastrojo, Alberto, Requena, Jose M., Solana, Jose C.   +5 more
core   +2 more sources

A novel approach for feline sporotrichosis pathogen detection based on loop‐mediated isothermal amplification

Veterinary Dermatology, Volume 36, Issue 4, Page 474-484, August 2025.
Background – Sporotrichosis is a chronic, mycotic infection caused by fungi of the genus Sporothrix. Zoonotic sporotrichosis occurs mainly through S. brasiliensis transmission, resulting from the organism's traumatic introduction via scratches or bites, or contact with exudate from contaminated cats.
Steffanie Amadei, Júlia Campos, Amanda Bertão‐Santos, Alis Frentzel, Hugo Ávila, Fabiana S. Monti, Marconi R. Farias   +6 more
wiley   +1 more source

Leishmania tarentolae: taxonomic classification and its application as a promising biotechnological expression host

, 2019
In this review, we summarize the current knowledge concerning the eukaryotic protozoan parasite Leishmania tarentolae, with a main focus on its potential for biotechnological applications.
Klatt, S., Konthur, Z., Maslov, D., Simpson, L.   +3 more
core   +1 more source

Geographic Distribution of Leishmania Species in Ecuador Based on the Cytochrome B Gene Sequence Analysis.

PLoS Neglected Tropical Diseases, 2016
A countrywide epidemiological study was performed to elucidate the current geographic distribution of causative species of cutaneous leishmaniasis (CL) in Ecuador by using FTA card-spotted samples and smear slides as DNA sources.
Hirotomo Kato, Eduardo A Gomez, Luiggi Martini-Robles, Jenny Muzzio, Lenin Velez, Manuel Calvopiña, Manuel Calvopiña, Daniel Romero-Alvarez, Tatsuyuki Mimori, Hiroshi Uezato, Yoshihisa Hashiguchi   +10 more
doaj   +1 more source

Distinct roles in autophagy and importance in infectivity of the two ATG4 cysteine peptidases of leishmania major [PDF]

, 2012
Macroautophagy in Leishmania, which is important for the cellular remodeling required during differentiation, relies upon the hydrolytic activity of two ATG4 cysteine peptidases (ATG4.1 and ATG4.2).
Afonso, Azad, Besteiro, Betin, Betin, Bhattacharya, Boya, Cabrera, Dalle-Donne, Deretic, Dolai, Dolai, Garami, Geng, Goldman, Graef, Graham H. Coombs, Hosokawa, Jeremy C. Mottram, Kim, Kimura, Kimura, Kirisako, Kirisako, Krebiehl, Köchl, Lee, Lemasters, Li, Manjithaya, Mariño, Mariño, Mariño, Medina-Acosta, Misslitz, Mortensen, Mottram, Mörck, Mörck, Nair, Okamoto, Read, Roderick A.M. Williams, Sacks, Schapira, Scherz-Shouval, Scherz-Shouval, Scherz-Shouval, Scherz-Shouval, Tanida, Tanida, Williams, Williams, Williams, Williams, Wong, Xie, Yoshimoto, Youle   +58 more
core   +1 more source

Population changes in Leishmania chagasi promastigote developmental stages due to serial passage [PDF]

, 2010
Leishmania chagasi causes visceral leishmaniasis, a potentially fatal disease of humans. Within the sand fly vector, L. chagasi replicates as promastigotes which undergo complex changes in morphology as they progress from early stage procyclic ...
Dahlin-Laborde R. R., Jeffrey K. Beetham, Lei S. M., Nathan M. Romine, Ramamoorthy R., Sacks D. L., Saraiva E. M., Soi Meng Lei, Walters L. L., Walters L. L., Walters L. L., Wilson M. E.   +11 more
core   +3 more sources