Results 61 to 70 of about 7,407 (178)

Evidence Gaps and Global Patterns in Leishmaniasis Control: A Scoping Review of Clinical, Diagnostic, and Treatment Strategies

Journal of Parasitology Research, Volume 2026, Issue 1, 2026.
Background Leishmaniasis is a neglected tropical disease with diverse clinical forms, heterogeneous geographical distribution, and persistent diagnostic and treatment challenges. Although substantial primary research exists, evidence remains fragmented, limiting integrated and context‐specific control strategies.
Muhi-deen Wonwana Mohammed, Yussif Owusu Aboagye, Akwasi Anyanful, Samuel Kyei, Kwame Kumi Asare, Pengfei Cai   +5 more
wiley   +1 more source

Eprinomectin Inhibits Leishmania by Inducing Mitochondrial Dysfunction and Cell Cycle Arrest

Transboundary and Emerging Diseases, Volume 2026, Issue 1, 2026.
Introduction Leishmaniasis remains a significant global health challenge, with current therapies often hampered by toxicity, resistance, and high cost. In this study, we investigated the antileishmanial potential of eprinomectin, a veterinary macrocyclic lactone, to address unmet therapeutic needs.
Mengtao Yu, Jiale Guo, Wenqi Liu, Yan Li, B. Shen   +4 more
wiley   +1 more source

PubChem BioAssays 1063: A Poorly Exploited Source of New Antileishmanial Compounds

Journal of Parasitology Research
PubChem Bioassays (AID 1063) reported the in vitro testing of 196,141 compounds against Leishmania major promastigotes. Although these results have been publicly available since 2008, limited efforts on further testing of some of these compounds has been
Sergio Sifontes-Rodríguez, Susana Meneses-Gómez, Alma Reyna Escalona-Montaño, Daniel Andrés Sánchez-Almaraz, Ofelia Pérez-Olvera, Aranza Regina Cañón Rosas, Pedro Zuriel Cruz Bautista, María Magdalena Aguirre-García   +7 more
doaj   +1 more source

Evaluación del efecto del ácido nalidíxico, ampicilina, kanamicina, penicilina G y polimixina B en los cultivos de promastigotes de leishmania

Biomédica: revista del Instituto Nacional de Salud, 1992
Se evaluó el efecto de diferentes concentraciones de ácido nalidíxico, ampicilina, kanarnicina, penicilina G y polimixina B, sobre la población de promastigotes de Leishmania braziliensis braziliensis , Leishmania donovani chagasi y Leishmania mexicana ...
Sofía Duque Beltrán, Augusto Corredor Arjona, Marleny Montilla Moreno, Dioselina Peláez Carvajal   +3 more
doaj   +1 more source

Geographic Distribution of Leishmania Species in Ecuador Based on the Cytochrome B Gene Sequence Analysis.

PLoS Neglected Tropical Diseases, 2016
A countrywide epidemiological study was performed to elucidate the current geographic distribution of causative species of cutaneous leishmaniasis (CL) in Ecuador by using FTA card-spotted samples and smear slides as DNA sources.
Hirotomo Kato, Eduardo A Gomez, Luiggi Martini-Robles, Jenny Muzzio, Lenin Velez, Manuel Calvopiña, Manuel Calvopiña, Daniel Romero-Alvarez, Tatsuyuki Mimori, Hiroshi Uezato, Yoshihisa Hashiguchi   +10 more
doaj   +1 more source

Functional and genetic evidence that nucleoside transport is highly conserved in Leishmania species: Implications for pyrimidine-based chemotherapy

International Journal for Parasitology: Drugs and Drug Resistance, 2017
Leishmania pyrimidine salvage is replete with opportunities for therapeutic intervention with enzyme inhibitors or antimetabolites. Their uptake into cells depends upon specific transporters; therefore it is essential to establish whether various ...
Khalid J.H. Alzahrani, Juma A.M. Ali, Anthonius A. Eze, Wan Limm Looi, Daniel N.A. Tagoe, Darren J. Creek, Michael P. Barrett, Harry P. de Koning   +7 more
doaj   +1 more source

Inhibition of glycosylphosphatidylinositol biosynthesis in Leishmania mexicana by mannosamine

Journal of Biological Chemistry, 1993
In several Leishmania species, glycosylated inositol phospholipids exist as free lipids, as membrane protein anchors, and as the membrane-binding moieties of the lipophosphoglycans. Both the glycolipid-anchored cell surface metalloproteinase, gp63, and the lipophosphoglycans have been proposed to be involved in cell invasion.
M C, Field, E, Medina-Acosta, G A, Cross
openaire   +2 more sources

Gluconeogenesis in Leishmania mexicana [PDF]

Journal of Biological Chemistry, 2014
Dayana Rodriguez-Contreras, Nicklas Hamilton   +1 more
openaire   +1 more source

Reacción de antígenos de Leishmania (Leishmania) mexicana con sueros de pacientes con leishmaniosis cutánea de Sinaloa, México Reaction of Leishmania (Leishmania) mexicana antigens by sera of patients with cutaneous leishmaniasis from Sinaloa, Mexico

Salud Pública de México, 2010
OBJETIVO: Detectar los antígenos de Leishmania (Leishmania) mexicana que reaccionan con sueros de pacientes con leishmaniosis cutánea (LC) de Sinaloa, México. MATERIAL Y MÉTODOS: Un extracto crudo de L.
Patricia Guadalupe Salazar-Mejía, Celia Rosa Tejeda-Aguirre, Héctor Samuel López-Moreno   +2 more
doaj  

Clinical and diagnostic aspects of feline cutaneous leishmaniosis in Venezuela

Parasites & Vectors, 2018
Background Venezuela is an endemic area for human and canine leishmaniosis due to Leishmania infantum and parasites of the Leishmania braziliensis and L. mexicana complexes. Limited data are available on feline leishmaniosis (FeL) in this region. The aim
Aruanai Kalú Rivas, Magdalena Alcover, Pamela Martínez-Orellana, Sara Montserrat-Sangrà, Yaarit Nachum-Biala, Mar Bardagí, Roser Fisa, Cristina Riera, Gad Baneth, Laia Solano-Gallego   +9 more
doaj   +1 more source