Results 61 to 70 of about 9,040 (224)

Sex in Immune Cells and Parasitic Diseases — A Complex Relationship

Immunological Reviews, Volume 337, Issue 1, January 2026.
ABSTRACT Epidemiological studies consistently show that many parasitic diseases affect males more frequently than females. These disparities are multifactorial, arising partly from gender‐specific behaviors that influence exposure risk and health‐seeking practices, especially in low‐ and middle‐income countries. Increasing evidence also highlights that
Barbara Honecker, Charlotte Sophie Hansen, Hanna Lotter   +2 more
wiley   +1 more source

Comparative expression profiling of Leishmania: modulation in gene expression between species and in different host genetic backgrounds. [PDF]

, 2009
Genome sequencing of Leishmania species that give rise to a range of disease phenotypes in the host has revealed highly conserved gene content and synteny across the genus.
Alasdair C Ivens, Ivens, Alasdair C, Maroof, Asher, Paul M Kaye, Depledge Daniel P., Depledge, DP, Ivens, AC, Depledge, Daniel P, Maroof Asher, Aziz Naveed, Evans, KJ, Smith, Deborah F, Kaye, PM, Maroof, A, Smith, DF, Aziz, Naveed, Daniel P Depledge, Naveed Aziz, Ivens Alasdair C., Asher Maroof, Krystal J Evans, Evans Krystal J., Kaye Paul M., Aziz, N, Evans, Krystal J, Smith Deborah F., Kaye, Paul M, Deborah F Smith   +27 more
core   +1 more source

Colonisation resistance in the sand fly gut: Leishmania protects Lutzomyia longipalpis from bacterial infection

Parasites & Vectors, 2014
Background Phlebotomine sand flies transmit the haemoflagellate Leishmania, the causative agent of human leishmaniasis. The Leishmania promastigotes are confined to the gut lumen and are exposed to the gut microbiota within female sand flies.
Mauricio RV Sant’Anna, Hector Diaz-Albiter, Kelsilândia Aguiar-Martins, Waleed S Al Salem, Reginaldo R Cavalcante, Viv M Dillon, Paul A Bates, Fernando A Genta, Rod J Dillon   +8 more
doaj   +1 more source

Mechanisms of Immune Evasion, Dissemination, and Persistence in Leishmania amazonensis Infection

Parasite Immunology, Volume 48, Issue 1, January 2026.
ABSTRACT Leishmania amazonensis is one of the etiological agents of cutaneous leishmaniasis in its localised form. Moreover, this parasite can cause more severe disease conditions, such as diffuse and disseminated cutaneous leishmaniasis. The development of more severe clinical manifestations is associated with the parasite's ability to establish a ...
Arieli Bernardo Portugal, Renato Augusto DaMatta, Edézio Ferreira da Cunha Júnior, João Luiz Mendes Wanderley   +3 more
wiley   +1 more source

Comparative study of the ability of Leishmania mexicana promastigotes and amastigotes to alter macrophage signalling and functions

, 2010
Leishmania alternates between two morphologically different stages: promastigotes and amastigotes. While the majority of reports focused on how the promastigote form can alter macrophage signalling and function, fewer reports investigated signalling ...
Hassani, K., Westra, E.R., Abu-Dayyeh, I., Edze R. Westra, Kasra Hassani, Issa Abu-Dayyeh, Mottram, J.C., Olivier, M., Jeremy C. Mottram, Martin Olivier   +9 more
core   +1 more source

Distinct roles in autophagy and importance in infectivity of the two ATG4 cysteine peptidases of leishmania major [PDF]

, 2013
Macroautophagy in Leishmania, which is important for the cellular remodeling required during differentiation, relies upon the hydrolytic activity of two ATG4 cysteine peptidases (ATG4.1 and ATG4.2).
Coombs, G.H., Williams, Roderick A M, Mottram, Jeremy C, Williams, R.A.M, Coombs, Graham H, Mottram, J.C., Jeremy C. Mottram, Graham H. Coombs, Roderick A.M. Williams   +8 more
core   +1 more source

Synthesis, Characterization, Antimicrobial Activity, Docking, and In Silico ADMET Analysis of Some New 2,3‐Dihydrobenzo[b][1,4]thiazepine Derivatives

BioMed Research International, Volume 2026, Issue 1, 2026.
A series of 2,3‐dihydrobenzo[b][1,4]thiazepine derivatives have been synthesized and characterized using IR, NMR, GC‐MS and microanalysis. The compounds were found to exhibit variable activity against Escherichia coli, Klebsiella pneumoniae, Enterococcus faecalis and Salmonella typhi with MIC values ranging from 1.88–15 mg/mL.
Felix Odame, Reuben Ayivor-Djanie, Tatenda Madanhire, Jaclyn Mann, David Neglo, Salifu Nanga, Emmanuel Hamenoo, Cedric Amengor, Susana Acheampong, Prince Biniyam, Takalani Mulaudzi, Nahit Gencer   +11 more
wiley   +1 more source

Interacting protein kinases involved in the regulation of flagellar length

, 2006
A striking difference of the life stages of the protozoan parasite Leishmania is a long flagellum in the insect stage promastigotes and a rudimentary organelle in the mammalian amastigotes.
Scholz, M., Melzer, I.M., Erdmann, M., Schmetz, C., Wiese, M.   +4 more
core   +1 more source

ATG5 is essential for ATG8-dependent autophagy and mitochondrial homeostasis in Leishmania major [PDF]

, 2012
Macroautophagy has been shown to be important for the cellular remodelling required for Leishmania differentiation. We now demonstrate that L. major contains a functional ATG12-ATG5 conjugation system, which is required for ATG8-dependent autophagosome ...
Williams, Roderick A M, Mottram, Jeremy C, Roderick A M Williams, Benjamin Cull, Mottram Jeremy C., Coombs, Graham H, Williams Roderick A. M., Cull Benjamin, Terry K Smith, Jeremy C. Mottram (112563), Graham H. Coombs (164011), Smith Terry K., Terry K. Smith (112550), Mottram, Jeremy C., Benjamin Cull (164010), Coombs Graham H., Coombs, Graham H., Smith, Terry K., Jeremy C Mottram, Smith, Terry K, Cull, Benjamin, Williams, Roderick A. M., Roderick A. M. Williams (164005), Graham H Coombs   +23 more
core   +1 more source

Visceral Leishmaniosis caused by Leishmania (L.) mexicana in a Mexican patient with human immunodeficiency virus infection

Memorias do Instituto Oswaldo Cruz, 2000
A 36 year old male was admitted in December 1997 to hospital with afternoon fever, malaise and hepatosplenomegaly. He also had a dry cough, dyspnoea and anaemia.
Carmen Ramos-Santos, Omar Hernandez-Montes, Gustavo Sanchez-Tejeda, Amalia Monroy-Ostria   +3 more
doaj   +1 more source