Results 51 to 60 of about 9,040 (224)
Proteophosophoglycans regurgitated by Leishmania-infected sand flies target the L-arginine metabolism of host macrophages to promote parasite survival [PDF]
All natural Leishmania infections start in the skin; however, little is known of the contribution made by the sand fly vector to the earliest events in mammalian infection, especially in inflamed skin that can rapidly kill invading parasites.
Podinovskaia, M +32 more
core +1 more source
ABSTRACT The green synthesis of metal oxide nanoparticles (MONPs) using plant‐based resources has gained significant traction as an environmentally benign, cost‐effective, and scalable alternative to traditional chemical and physical methods. This review comprehensively explores the plant‐mediated synthesis routes for a variety of MONPs, including CuO,
Faith Mwangi, Jannatun Zia, Ufana Riaz
wiley +1 more source
Leishmaniases are a group of important diseases transmitted to humans through the bite of sandfly vectors. Several forms of leishmaniases are endemic in Mexico and especially in the Southeast region.
Rodríguez-Rojas Jorge J. +8 more
doaj +1 more source
Se evidencia la presencia de promastigotos metacíclicos de Leishmania pifanoi en el conducto hipofaríngeo de Lutzomyia youngi infectados experimentalmente por ingurgitación sobre lesiones tarsales de hámsteres.
Elina Rojas, José V. Scorza
doaj +1 more source
Down-Regulation of TLR and JAK/STAT Pathway Genes Is Associated with Diffuse Cutaneous Leishmaniasis: A Gene Expression Analysis in NK Cells from Patients Infected with Leishmania mexicana. [PDF]
An important NK-cell inhibition with reduced TNF-α, IFN-γ and TLR2 expression had previously been identified in patients with diffuse cutaneous leishmaniasis (DCL) infected with Leishmania mexicana.
Edith A Fernández-Figueroa +6 more
doaj +1 more source
The Leishmania phosphatase PTP1, and possibly the genetically similar PTP2, interacts with the Leishmania transmembrane protein DUF21. When both ptp1 and ptp2 are knocked out of Leishmania (LdΔPTP1/2), the parasite can no longer survive without magnesium in vitro and has reduced viability in the host macrophage. Conversely, in duf21 knockout (LdΔDUF21),
Kayla Paulini +6 more
wiley +1 more source
Purification and Characterization of Proteolytic Enzymes of Leishmania mexicana mexicana Amastigotes and Promastigotes [PDF]
Leishmania mexicana mexicana amastigote and promastigote soluble proteinases were purified using gel filtration and ion exchange chromatography. For the amastigotes, two main proteinase activity peaks were separated with both methods. These accounted for approximately 10% and 90% of the total activity.
M F, Pupkis, G H, Coombs
openaire +2 more sources
Sex‐Specific Factors Influencing HIV Infection
ABSTRACT Immune responses are key in controlling viral infections such as HIV‐1, which remains a global challenge to public health. X/Y‐chromosome‐encoded genes and sex steroid hormones can modulate immune cells and drive distinct patterns of gene and protein expression involved in antiviral function, impacting sex‐dependent immune responses and ...
Maria Pujantell, Marcus Altfeld
wiley +1 more source
IgG1 Is Pathogenic in Leishmania mexicana Infection [PDF]
Abstract There are >2 million new cases of leishmaniasis annually, and no effective vaccine has been developed to prevent infection. In murine infection, Leishmania mexicana, which lives intracellularly in host macrophages, has developed pathways to hijack host IgG to induce a suppressive IL-10 response through FcγRs, the cell ...
Niansheng, Chu +3 more
openaire +2 more sources
Background: Determinants of the clinical presentation of the leishmaniases are poorly understood but Leishmania species and strain differences are important.
Cooper Philip J +48 more
core +1 more source

