Results 31 to 40 of about 9,040 (224)

Systematic functional analysis of Leishmania protein kinases identifies regulators of differentiation or survival

Nature Communications, 2021
Protein kinases are fundamental in cellular signalling required for Leishmania survival throughout the life cycle. Here, Baker and Catta-Preta et al. report on a kinome-wide functional study in Leishmania mexicana to define protein kinases with roles in ...
N. Baker, C. M. C. Catta-Preta, R. Neish, J. Sadlova, B. Powell, E. V. C. Alves-Ferreira, V. Geoghegan, J. B. T. Carnielli, K. Newling, C. Hughes, B. Vojtkova, J. Anand, A. Mihut, P. B. Walrad, L. G. Wilson, J. W. Pitchford, P. Volf, J. C. Mottram   +17 more
doaj   +1 more source

Leishmania manipulation of sand fly feeding behavior results in enhanced transmission [PDF]

, 2007
In nature the prevalence of Leishmania infection in whole sand fly populations can be very low (
Rogers, Matthew E, Rogers Matthew E, Bates, Paul, Matthew E. Rogers, Matthew E Rogers, Bates, Paul A, Paul A Bates, Rogers, Matthew E., Bates Paul A, Paul A. Bates   +9 more
core   +1 more source

Leishmania (L.) mexicana infected bats in Mexico: novel potential reservoirs.

PLoS Neglected Tropical Diseases, 2015
Leishmania (Leishmania) mexicana causes cutaneous leishmaniasis, an endemic zoonosis affecting a growing number of patients in the southeastern states of Mexico.
Miriam Berzunza-Cruz, Ángel Rodríguez-Moreno, Gabriel Gutiérrez-Granados, Constantino González-Salazar, Christopher R Stephens, Mircea Hidalgo-Mihart, Carlos F Marina, Eduardo A Rebollar-Téllez, Dulce Bailón-Martínez, Cristina Domingo Balcells, Carlos N Ibarra-Cerdeña, Víctor Sánchez-Cordero, Ingeborg Becker   +12 more
doaj   +1 more source

Leishmania (Leishmania) mexicana Infection in Wild Rodents from an Emergent Focus of Cutaneous Leishmaniasis in Yucatan, Mexico

Journal of Tropical Medicine, 2022
In 2015, emergent cases of localized cutaneous leishmaniasis (LCL) were reported in Tinum, Yucatan, Mexico. As part of an eco-epidemiological study to characterize the elements that trigger Leishmania infection in that area, we conducted a field study to
Erika I. Sosa-Bibiano, Luis A. Sánchez -Martínez, Karina B. López-Ávila, Juan B. Chablé-Santos, Jimmy R. Torres-Castro, Edith A. Fernández-Figueroa, Claudia Rangel-Escareño, Elsy N. Loría-Cervera   +7 more
doaj   +1 more source

Gene editing and scalable functional genomic screening in Leishmania species using the CRISPR/Cas9 cytosine base editor toolbox LeishBASEedit

eLife, 2023
CRISPR/Cas9 gene editing has revolutionised loss-of-function experiments in Leishmania, the causative agent of leishmaniasis. As Leishmania lack a functional non-homologous DNA end joining pathway however, obtaining null mutants typically requires ...
Markus Engstler, Tom Beneke
doaj   +1 more source

Nitric oxide production by Peromyscus yucatanicus (Rodentia) infected with Leishmania (Leishmania) mexicana

Memorias do Instituto Oswaldo Cruz, 2013
Peromyscus yucatanicus (Rodentia: Cricetidae) is a primary reservoir of Leishmania (Leishmania) mexicana (Kinetoplastida: Trypanosomatidae). Nitric oxide (NO) generally plays a crucial role in the containment and elimination of Leishmania.
Elsy Nalleli Loría-Cervera, Erika Ivett Sosa-Bibiano, Liliana Estefanía Villanueva-Lizama, Nicole Raymonde Van Wynsberghe, Silvia Beatriz Canto-Lara, José Luis Batún-Cutz, Fernando José Andrade-Narváez   +6 more
doaj   +1 more source

Proteomic analysis of Leishmania mexicana differentiation

Molecular and Biochemical Parasitology, 2004
We have resolved the proteome of axenically differentiated Leishmania mexicana parasites by two-dimensional gel electrophoresis (2DE), employing optimised, robust and reproducible procedures, and visualised (by silver staining) approximately 2000 protein species in each of three developmental stages: procyclic promastigotes, metacyclic promastigotes ...
Nugent, P, Karsani, SA, Wait, R, Tempero, J, Smith, D   +4 more
openaire   +3 more sources

Real-time imaging of Leishmania mexicana-infected early phagosomes: a study using primary macrophages generated from green fluorescent protein-Rab5 transgenic mice

, 2009
The small GTPase Rab5 is a key regulator of endosome/phagosome maturation and in intravesicular infections marks a phagosome stage at which decisions over pathogen replication or destruction are integrated.
Paape, Daniel, Blackburn, Clare, Lippuner, C., Smith, Andrew, Smith, A. J., Paterou, A., Brand, J., Richardson, Melville, Richardson, M., Blackburn, C., Andrew J. Smith, Volker Brinkmann, Brinkmann, Volker, Janko Brand, Smith, A., Brinkmann, V., Daniel Paape, Toni Aebischer, Brand, Janko, Hoffmann, Kirstin, Hoffmann, K., Athina Paterou, Kirstin Hoffmann, Aebischer, Toni, Paterou, Athina, Paape, D., Clare Blackburn, Smith, Andrew J., Melville Richardson, Aebischer, T., Christoph Lippuner, Lippuner, Christoph   +31 more
core   +1 more source

High throughput screens yield small molecule inhibitors of Leishmania CRK3:CYC6 cyclin-dependent kinase [PDF]

, 2011
<p><b>Background:</b> <i>Leishmania</i> species are parasitic protozoa that have a tightly controlled cell cycle, regulated by cyclin-dependent kinases (CDKs).
Mottram Jeremy C., Thomson, Graeme, Mottram, JC, Grant Karen M., Turner, N.J., Malcolm D. Walkinshaw, Malone, Kirk, Turner, Nicholas J., Nicholas J Turner, Jeremy C. Mottram, Karen M. Grant, Walker, Roderick G., Kita, K, Graeme Thomson, Malone Kirk, Karen M Grant, Grant, Karen, Nicholas J. Turner, Walker, RG, Nowicki, Matthew W., Thomson Graeme, Walkinshaw, M.D., Walkinshaw Malcolm D., David G. Blake, David G Blake, Walker Roderick G., Brown, Elaine, Brown Elaine, Blake David G., Brown, E, Malone, K, Turner Nicholas J., Walkinshaw, MD, Blake, DG, Matthew W. Nowicki, Walker, R.G., Malone, K., Blake, David G., Elaine Brown, Mottram, J.C., Kirk Malone, Walkinshaw, Malcolm D., Matthew W Nowicki, Nowicki, MW, Brown, E., Nowicki Matthew W., Turner, Nicholas J.; id_orcid, Grant, Karen M., Grant, K.M., Mottram, Jeremy C., Roderick G Walker, Thomson, G, Jeremy C Mottram, Roderick G. Walker, Nowicki, M.W., Grant, KM, Blake, D.G., Malcolm D Walkinshaw, Turner, NJ, Thomson, G.   +59 more
core   +1 more source

Thymus and Leishmania at the Crossroads: Autoimmunity and Cancer

Immunology, Volume 178, Issue 3, Page 377-386, July 2026.
Conceptual ‘Crossroads Model’ linking Leishmania, thymic infection and immune dysregulation: an integrative model is proposed in which Leishmania infection disrupts thymic architecture and stromal–thymocyte interactions. These alterations converge to promote defective tolerance, increased autoimmune risk and a microenvironment permissive to malignant ...
Alef Batista Bezerra Barros, Gabriel Augusto Leite, Arthur Gomes de Andrade, Maria Danielma dos Santos Reis, Luiz Henrique Agra Cavalcante‐Silva, Marvin Paulo Lins   +5 more
wiley   +1 more source